Synthesis of Functionalized Pyrrolidinone Scaffolds via Smiles-Truce Cascade

por Sephton, Thomas, Large, Jonathan M., Butterworth, Sam, Greaney, Michael F.
Publicado 2023

Diarylamine Synthesis via Desulfinylative Smiles Rearrangement

por Sephton, Thomas, Large, Jonathan M., Butterworth, Sam, Greaney, Michael F.
Publicado 2022

Structure of Rhomboid Protease in Complex with β-Lactam Inhibitors Defines the S2′ Cavity

por Vinothkumar, Kutti R., Pierrat, Olivier A., Large, Jonathan M., Freeman, Matthew
Publicado 2013

Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs

por Baker, David A., Matralis, Alexios N., Osborne, Simon A., Large, Jonathan M., Penzo, Maria
Publicado 2020

Developing an Antibody–Drug Conjugate Approach to Selective Inhibition of an Extracellular Protein

por Love, Elizabeth A., Sattikar, Afrah, Cook, Hannah, Gillen, Kevin, Large, Jonathan M., Patel, Seema, Matthews, David, Merritt, Andy
Publicado 2019

A “Target Class” Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels

por McCoull, David, Ococks, Emma, Large, Jonathan M., Tickle, David C., Mathie, Alistair, Jerman, Jeffrey, Wright, Paul D.
Publicado 2020

Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues()

por Large, Jonathan M., Osborne, Simon A., Smiljanic-Hurley, Ela, Ansell, Keith H., Jones, Hayley M., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Publicado 2013

Corrigendum to “Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogu...

por Large, Jonathan M., Osborne, Simon A., Smiljanic-Hurley, Ela, Ansell, Keith H., Jones, Hayley M., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Publicado 2014

Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)

por Chapman, Timothy M., Osborne, Simon A., Bouloc, Nathalie, Large, Jonathan M., Wallace, Claire, Birchall, Kristian, Ansell, Keith H., Jones, Hayley M., Taylor, Debra, Clough, Barbara, Green, Judith L., Holder, Anthony A.
Publicado 2013

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines

por Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Publicado 2019

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty

por Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Publicado 2019

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

por Baker, David A., Stewart, Lindsay B., Large, Jonathan M., Bowyer, Paul W., Ansell, Keith H., Jiménez-Díaz, María B., El Bakkouri, Majida, Birchall, Kristian, Dechering, Koen J., Bouloc, Nathalie S., Coombs, Peter J., Whalley, David, Harding, Denise J., Smiljanic-Hurley, Ela, Wheldon, Mary C., Walker, Eloise M., Dessens, Johannes T., Lafuente, María José, Sanz, Laura M., Gamo, Francisco-Javier, Ferrer, Santiago B., Hui, Raymond, Bousema, Teun, Angulo-Barturén, Iñigo, Merritt, Andy T., Croft, Simon L., Gutteridge, Winston E., Kettleborough, Catherine A., Osborne, Simon A.
Publicado 2017