Population pharmacokinetics and pharmacodynamics of a novel vascular adhesion protein-1 inhibitor using a multiple-target mediated drug disposition model

por Snelder, Nelleke, Hoefman, Sven, Garcia-Hernandez, Alberto, Onkels, Hartmut, Larsson, Tobias E., Bergmann, Kirsten R.
Publicado 2020

NPT-IIb Inhibition Does Not Improve Hyperphosphatemia in CKD

por Larsson, Tobias E., Kameoka, Chisato, Nakajo, Ikumi, Taniuchi, Yuta, Yoshida, Satoshi, Akizawa, Tadao, Smulders, Ronald A.
Publicado 2017

Mechanism-based modeling of the effect of a novel inhibitor of vascular adhesion protein-1 on albuminuria and renal function markers in patients with diabetic kidney disease

por Hoefman, Sven, Snelder, Nelleke, van Noort, Martijn, Garcia-Hernandez, Alberto, Onkels, Hartmut, Larsson, Tobias E., Bergmann, Kirsten R.
Publicado 2020

Klotho controls the brain–immune system interface in the choroid plexus

por Zhu, Lei, Stein, Liana R., Kim, Daniel, Ho, Kaitlyn, Yu, Gui-Qiu, Zhan, Lihong, Larsson, Tobias E., Mucke, Lennart
Publicado 2018

Fibroblast growth factor 23, mineral metabolism and mortality among elderly men (Swedish MrOs)

por Westerberg, Per-Anton, Tivesten, Åsa, Karlsson, Magnus K, Mellström, Dan, Orwoll, Eric, Ohlsson, Claes, Larsson, Tobias E, Linde, Torbjörn, Ljunggren, Östen
Publicado 2013

Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion

por Olauson, Hannes, Lindberg, Karolina, Amin, Risul, Sato, Tadatoshi, Jia, Ting, Goetz, Regina, Mohammadi, Moosa, Andersson, Göran, Lanske, Beate, Larsson, Tobias E.
Publicado 2013

Arterial Klotho Expression and FGF23 Effects on Vascular Calcification and Function

por Lindberg, Karolina, Olauson, Hannes, Amin, Risul, Ponnusamy, Arvind, Goetz, Regina, Taylor, Rebecca F., Mohammadi, Moosa, Canfield, Ann, Kublickiene, Karolina, Larsson, Tobias E.
Publicado 2013

A novel model of adenine-induced tubulointerstitial nephropathy in mice

por Jia, Ting, Olauson, Hannes, Lindberg, Karolina, Amin, Risul, Edvardsson, Karin, Lindholm, Bengt, Andersson, Göran, Wernerson, Annika, Sabbagh, Yves, Schiavi, Susan, Larsson, Tobias E
Publicado 2013

Longitudinal change in c-terminal fibroblast growth factor 23 and outcomes in patients with advanced chronic kidney disease

por Alderson, Helen V., Chinnadurai, Rajkumar, Ibrahim, Sara T., Asar, Ozgur, Ritchie, James P., Middleton, Rachel, Larsson, Anders, Diggle, Peter J., Larsson, Tobias E., Kalra, Philip A.
Publicado 2021

A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy

por Arbel Rubinstein, Tammi, Reuveni, Inbal, Hesin, Arkadi, Klein-Goldberg, Anat, Olauson, Hannes, Larsson, Tobias E., Abraham, Carmela R., Zeldich, Ella, Bosch, Assumpció, Chillón, Miguel, Hollander, Kenneth Samuel, Shabtay-Orbach, Ayelet, Vainer, Gilad W., Wolf, Ido, Rubinek, Tami
Publicado 2021

Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microg...

por Mazer, C David, Siadati-Fini, Niloufar, Boehm, Johannes, Wirth, Felix, Myjavec, Andrej, Brown, Craig D, Koyner, Jay L, Boening, Andreas, Engelman, Daniel T, Larsson, Tobias E, Renfurm, Ronny, de Varennes, Benoit, Noiseux, Nicolas, Thielmann, Matthias, Lamy, Andre, Laflamme, Maxime, von Groote, Thilo, Ronco, Claudio, Zarbock, Alexander
Publicado 2023