Association of Skin with the Pathogenesis and Treatment of Neurodegenerative Amyloidosis

por Clos, Audra L., Kayed, Rakez, Lasagna-Reeves, Cristian A.
Publicado 2012

The reduction of astrocytic tau prevents amyloid-β-induced synaptotoxicity

por Cisternas, Pablo, Taylor, Xavier, Martinez, Pablo, Maldonado, Orlando, Jury, Nur, Lasagna-Reeves, Cristian A
Publicado 2022

Characterization of tau oligomeric seeds in progressive supranuclear palsy

por Gerson, Julia E, Sengupta, Urmi, Lasagna-Reeves, Cristian A, Guerrero-Muñoz, Marcos J, Troncoso, Juan, Kayed, Rakez
Publicado 2014

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

por Lasagna-Reeves, Cristian A, Castillo-Carranza, Diana L, Sengupta, Urmi, Clos, Audra L, Jackson, George R, Kayed, Rakez
Publicado 2011

A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy

por Taylor, Xavier, Cisternas, Pablo, You, Yanwen, You, Yingjian, Xiang, Shunian, Marambio, Yamil, Zhang, Jie, Vidal, Ruben, Lasagna-Reeves, Cristian A.
Publicado 2020

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

por Lasagna-Reeves, Cristian A., Castillo-Carranza, Diana L., Sengupta, Urmi, Guerrero-Munoz, Marcos J., Kiritoshi, Takaki, Neugebauer, Volker, Jackson, George R., Kayed, Rakez
Publicado 2012

The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes

por Lasagna-Reeves, Cristian A, Sengupta, Urmi, Castillo-Carranza, Diana, Gerson, Julia E, Guerrero-Munoz, Marcos, Troncoso, Juan C, Jackson, George R, Kayed, Rakez
Publicado 2014

Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer’s disease

por Jury-Garfe, Nur, You, Yanwen, Martínez, Pablo, Redding-Ochoa, Javier, Karahan, Hande, Johnson, Travis S., Zhang, Jie, Kim, Jungsu, Troncoso, Juan C., Lasagna-Reeves, Cristian A.
Publicado 2023

Activated endothelial cells induce a distinct type of astrocytic reactivity

por Taylor, Xavier, Cisternas, Pablo, Jury, Nur, Martinez, Pablo, Huang, Xiaoqing, You, Yanwen, Redding-Ochoa, Javier, Vidal, Ruben, Zhang, Jie, Troncoso, Juan, Lasagna-Reeves, Cristian A.
Publicado 2022

TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo

por Lee-Gosselin, Audrey, Jury-Garfe, Nur, You, Yanwen, Dabin, Luke, Soni, Disha, Dutta, Sayan, Rochet, Jean-Christophe, Kim, Jungsu, Oblak, Adrian L., Lasagna-Reeves, Cristian A.
Publicado 2023

Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy

por You, Yingjian, Perkins, Abigail, Cisternas, Pablo, Muñoz, Braulio, Taylor, Xavier, You, Yanwen, Garringer, Holly J., Oblak, Adrian L., Atwood, Brady K., Vidal, Ruben, Lasagna-Reeves, Cristian A.
Publicado 2019

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes

por Lasagna-Reeves, Cristian A, Rousseaux, Maxime WC, Guerrero-Munoz, Marcos J, Vilanova-Velez, Luis, Park, Jeehye, See, Lauren, Jafar-Nejad, Paymaan, Richman, Ronald, Orr, Harry T, Kayed, Rakez, Zoghbi, Huda Y
Publicado 2015

Vascular amyloid accumulation alters the gabaergic synapse and induces hyperactivity in a model of cerebral amyloid angiopathy

por Cisternas, Pablo, Taylor, Xavier, Perkins, Abigail, Maldonado, Orlando, Allman, Elysabeth, Cordova, Ricardo, Marambio, Yamil, Munoz, Braulio, Pennington, Taylor, Xiang, Shunian, Zhang, Jie, Vidal, Ruben, Atwood, Brady, Lasagna‐Reeves, Cristian A.
Publicado 2020

A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1

por Lasagna-Reeves, Cristian A, Rousseaux, Maxime WC, Guerrero-Muñoz, Marcos J, Park, Jeehye, Jafar-Nejad, Paymaan, Richman, Ronald, Lu, Nan, Sengupta, Urmi, Litvinchuk, Alexandra, Orr, Harry T, Kayed, Rakez, Zoghbi, Huda Y
Publicado 2015

CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease

por Puntambekar, Shweta S., Moutinho, Miguel, Lin, Peter Bor-Chian, Jadhav, Vaishnavi, Tumbleson-Brink, Danika, Balaji, Ananya, Benito, Martin Alvarado, Xu, Guixiang, Oblak, Adrian, Lasagna-Reeves, Cristian A., Landreth, Gary E., Lamb, Bruce T.
Publicado 2022

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

por Bemiller, Shane M., McCray, Tyler J., Allan, Kevin, Formica, Shane V., Xu, Guixiang, Wilson, Gina, Kokiko-Cochran, Olga N., Crish, Samuel D., Lasagna-Reeves, Cristian A., Ransohoff, Richard M., Landreth, Gary E., Lamb, Bruce T.
Publicado 2017

TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation

por Moutinho, Miguel, Coronel, Israel, Tsai, Andy P., Di Prisco, Gonzalo Viana, Pennington, Taylor, Atwood, Brady K., Puntambekar, Shweta S., Smith, Daniel C., Martinez, Pablo, Han, Seonggyun, Lee, Younghee, Lasagna-Reeves, Cristian A., Lamb, Bruce T., Bissel, Stephanie J., Nho, Kwangsik, Landreth, Gary E.
Publicado 2023

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

por Rousseaux, Maxime WC, de Haro, Maria, Lasagna-Reeves, Cristian A, De Maio, Antonia, Park, Jeehye, Jafar-Nejad, Paymaan, Al-Ramahi, Ismael, Sharma, Ajay, See, Lauren, Lu, Nan, Vilanova-Velez, Luis, Klisch, Tiemo J, Westbrook, Thomas F, Troncoso, Juan C, Botas, Juan, Zoghbi, Huda Y
Publicado 2016

Network analysis identifies strain-dependent response to tau and tau seeding-associated genes

por Acri, Dominic J., You, Yanwen, Tate, Mason D., Karahan, Hande, Martinez, Pablo, McCord, Brianne, Sharify, A. Daniel, John, Sutha, Kim, Byungwook, Dabin, Luke C., Philtjens, Stéphanie, Wijeratne, H.R. Sagara, McCray, Tyler J., Smith, Daniel C., Bissel, Stephanie J., Lamb, Bruce T., Lasagna-Reeves, Cristian A., Kim, Jungsu
Publicado 2023

Bassoon contributes to tau-seed propagation and neurotoxicity

por Martinez, Pablo, Patel, Henika, You, Yanwen, Jury, Nur, Perkins, Abigail, Lee-Gosselin, Audrey, Taylor, Xavier, You, Yingjian, Viana Di Prisco, Gonzalo, Huang, Xiaoqing, Dutta, Sayan, Wijeratne, Aruna B., Redding-Ochoa, Javier, Shahid, Syed Salman, Codocedo, Juan F., Min, Sehong, Landreth, Gary E., Mosley, Amber L., Wu, Yu-Chien, McKinzie, David L., Rochet, Jean-Christophe, Zhang, Jie, Atwood, Brady K., Troncoso, Juan, Lasagna-Reeves, Cristian A.
Publicado 2022