Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study

por Elmenier, Fatma M., Lasheen, Deena S., Abouzid, Khaled A. M.
Publicado 2021

Elaborating piperazinyl-furopyrimidine based scaffolds as phosphoinositol-3-kinase enzyme alpha (PI3Kα) inhibitors to combat pancreatic cancer

por Mansour, Mai A., Lasheen, Deena S., Gaber, Hatem M., Abouzid, Khaled A. M.
Publicado 2020

Design, molecular modelling and synthesis of novel benzothiazole derivatives as BCL-2 inhibitors

por Ismail, Hoda S., Khalil, Amira, Taha, Rabah A., Lasheen, Deena S., Abou El Ella, Dalal A.
Publicado 2023

Identification of novel furo[2,3-d]pyrimidine based chalcones as potent anti-breast cancer agents: synthesis, in vitro and in vivo biological evaluation

por Mansour, Mai A., Oraby, Mamdouh A., Muhammad, Zeinab A., Lasheen, Deena S., Gaber, Hatem M., Abouzid, Khaled A. M.
Publicado 2022

Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome m...

por Abdelhafiz, Abeer H. A., Serya, Rabah A. T., Lasheen, Deena S., Wang, Nessa, Sobeh, Mansour, Wink, Michael, Abouzid, Khaled A. M.
Publicado 2022

A Fluorescence-Based Assay to Probe Inhibitory Effect of Fructose Mimics on GLUT5 Transport in Breast Cancer Cells

por Rana, Natasha, Aziz, Marwa A., Serya, Rabah A. T., Lasheen, Deena S., Samir, Nermin, Wuest, Frank, Abouzid, Khaled A. M., West, F. G.
Publicado 2022

Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition

por Elmeligie, Salwa, Aboul-Magd, Asmaa M., Lasheen, Deena S., Ibrahim, Tamer M., Abdelghany, Tamer M., Khojah, Sohair M., Abouzid, Khaled A. M.
Publicado 2019

Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents

por Aziz, Marwa A., Serya, Rabah A. T., Lasheen, Deena S., Abdel-Aziz, Amal Kamal, Esmat, Ahmed, Mansour, Ahmed M., Singab, Abdel Nasser B., Abouzid, Khaled A. M.
Publicado 2016

Synthesis, Characterization, and Evaluation of Cytotoxic Effects of Novel Hybrid Steroidal Heterocycles as PEG Based Nanoparticles

por Elhalim, Mervat M Abd, Ismail, Nasser S M, Yahya, Shaymaa M M, Omar, Yasmin Y, Rabou, Ahmed A Abd, Lasheen, Deena S, Zawrah, Mahmoud F, Elmegeed, Gamal A
Publicado 2017