Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression

por Ruiz-Riquelme, Alejandro, Lau, Heather H. C., Stuart, Erica, Goczi, Adrienn N., Wang, Zhilan, Schmitt-Ulms, Gerold, Watts, Joel C.
Publicado 2018

Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice

por Ruiz-Riquelme, Alejandro, Mao, Alison, Barghash, Marim M., Lau, Heather H. C., Stuart, Erica, Kovacs, Gabor G., Nilsson, K. Peter R., Fraser, Paul E., Schmitt-Ulms, Gerold, Watts, Joel C.
Publicado 2021

The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease

por Lau, Heather H. C., Martinez-Valbuena, Ivan, So, Raphaella W. L., Mehra, Surabhi, Silver, Nicholas R. G., Mao, Alison, Stuart, Erica, Schmitt-Ulms, Cian, Hyman, Bradley T., Ingelsson, Martin, Kovacs, Gabor G., Watts, Joel C.
Publicado 2023

Application of CRISPR genetic screens to investigate neurological diseases

por So, Raphaella W. L., Chung, Sai Wai, Lau, Heather H. C., Watts, Jeremy J., Gaudette, Erin, Al-Azzawi, Zaid A. M., Bishay, Jossana, Lin, Lilian Tsai-Wei, Joung, Julia, Wang, Xinzhu, Schmitt-Ulms, Gerold
Publicado 2019

Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy

por Martinez-Valbuena, Ivan, Visanji, Naomi P., Kim, Ain, Lau, Heather H. C., So, Raphaella W. L., Alshimemeri, Sohaila, Gao, Andrew, Seidman, Michael A., Luquin, Maria R., Watts, Joel C., Lang, Anthony E., Kovacs, Gabor G.
Publicado 2022

α-Synuclein Strains Target Distinct Brain Regions and Cell Types

por Lau, Angus, So, Raphaella W.L., Lau, Heather H.C., Sang, Jason C., Ruiz-Riquelme, Alejandro, Fleck, Shelaine C., Stuart, Erica, Menon, Sindhu, Visanji, Naomi P., Meisl, Georg, Faidi, Rania, Marano, Maria M., Schmitt-Ulms, Cian, Wang, Zhilan, Fraser, Paul E., Tandon, Anurag, Hyman, Bradley T., Wille, Holger, Ingelsson, Martin, Klenerman, David, Watts, Joel C.
Publicado 2019