Translating palbociclib to the clinic for DIPG - What is truly achievable?

por Franshaw, Laura, Tsoli, Maria, Lau, Loretta M.S., Ziegler, David S.
Publicado 2019

Detection of alternative lengthening of telomeres by telomere quantitative PCR

por Lau, Loretta M. S., Dagg, Rebecca A., Henson, Jeremy D., Au, Amy Y. M., Royds, Janice A., Reddel, Roger R.
Publicado 2013

Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes

por Lee, Michael, Hills, Mark, Conomos, Dimitri, Stutz, Michael D., Dagg, Rebecca A., Lau, Loretta M.S., Reddel, Roger R., Pickett, Hilda A.
Publicado 2014

Neuroblastoma, Body Mass Index, and Survival: A Retrospective Analysis

por Small, Annabel G., Thwe, Le M., Byrne, Jennifer A., Lau, Loretta, Chan, Albert, Craig, Maria E., Cowell, Chris T., Garnett, Sarah P.
Publicado 2015

Loss of Wild-Type ATRX Expression in Somatic Cell Hybrids Segregates with Activation of Alternative Lengthening of Telomeres

por Bower, Kylie, Napier, Christine E., Cole, Sara L., Dagg, Rebecca A., Lau, Loretta M. S., Duncan, Emma L., Moy, Elsa L., Reddel, Roger R.
Publicado 2012

Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis

por Manoharan, Neevika, Ajuyah, Pamela, Senapati, Akanksha, Wong, Marie, Mullins, Anna, Rodriguez, Michael, Doyle, Helen, McCowage, Geoff, Lau, Loretta M. S., Ekert, Paul G., Ziegler, David S.
Publicado 2021

HGG-20. NOVEL PAEDIATRIC CASE OF A SPINAL HIGH-GRADE ASTROCYTOMA WITH PILOID FEATURES IN A PATIENT WITH NOONAN SYNDROME

por Staunton, Jordan, Robertson, Pamela Ajuyah, Harris, Angela, Mayoh, Chelsea, Wong, Marie, Rumford, Megan, Fuentes-Bolanos, Noemi, Cowley, Mark, Lau, Loretta, Ziegler, David S, Barahona, Paulette, Manoharan, Neevika
Publicado 2023

The C-Circle Biomarker Is Secreted by Alternative-Lengthening-of-Telomeres Positive Cancer Cells inside Exosomes and Provides a Blood-Based Diagnostic for ALT Activity

por Chen, Yuan-Yin, Dagg, Rebecca, Zhang, Yuchen, Lee, Joyce H. Y., Lu, Robert, Martin La Rotta, Nancy, Sampl, Sandra, Korkut-Demirbaş, Medina, Holzmann, Klaus, Lau, Loretta M. S., Reddel, Roger R., Henson, Jeremy D.
Publicado 2021

Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor

por Nagabushan, Sumanth, Lau, Loretta M. S., Barahona, Paulette, Wong, Marie, Sherstyuk, Alexandra, Marshall, Glenn M., Tyrrell, Vanessa, Wegner, Eva A., Ekert, Paul G., Cowley, Mark J., Mayoh, Chelsea, Trahair, Toby N., Crowe, Philip, Anazodo, Antoinette, Ziegler, David S.
Publicado 2021

“Balancing Expectations with Actual Realities”: Conversations with Clinicians and Scientists in the First Year of a High-Risk Childhood Cancer Precision Medicine Trial

por McGill, Brittany C., Wakefield, Claire E., Hetherington, Kate, Munro, Lachlan J., Warby, Meera, Lau, Loretta, Tyrrell, Vanessa, Ziegler, David S., O’Brien, Tracey A., Marshall, Glenn M., Malkin, David, Hansford, Jordan R., Tucker, Katherine M., Vetsch, Janine
Publicado 2020

Hopes, concerns, satisfaction and regret in a precision medicine trial for childhood cancer: a mixed-methods study of parent and patient perspectives

por Wakefield, Claire E., Hetherington, Kate, Robertson, Eden G., Donoghoe, Mark W., Hunter, Jacqueline D., Vetsch, Janine, Marron, Jonathan M., Tucker, Katherine M., Marshall, Glenn M., Broom, Alexander, Haber, Michelle, Tyrrell, Vanessa, Malkin, David, Lau, Loretta, Mateos, Marion K., O’Brien, Tracey A., Ziegler, David S.
Publicado 2023

qmotif: determination of telomere content from whole-genome sequence data

por Holmes, Oliver, Nones, Katia, Tang, Yue Hang, Loffler, Kelly A, Lee, Michael, Patch, Ann-Marie, Dagg, Rebecca A, Lau, Loretta M S, Leonard, Conrad, Wood, Scott, Xu, Qinying, Pickett, Hilda A, Reddel, Roger R, Barbour, Andrew P, Grimmond, Sean M, Waddell, Nicola, Pearson, John V
Publicado 2022

Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma

por Ziegler, David S., Wong, Marie, Mayoh, Chelsea, Kumar, Amit, Tsoli, Maria, Mould, Emily, Tyrrell, Vanessa, Khuong-Quang, Dong-Anh, Pinese, Mark, Gayevskiy, Velimir, Cohn, Richard J., Lau, Loretta M. S., Reynolds, Mark, Cox, Michael C., Gifford, Andrew, Rodriguez, Michael, Cowley, Mark J., Ekert, Paul G., Marshall, Glenn M., Haber, Michelle
Publicado 2018

Recurrent SPECC1L–NTRK fusions in pediatric sarcoma and brain tumors

por Khuong-Quang, Dong-Anh, Brown, Lauren M., Wong, Marie, Mayoh, Chelsea, Sexton-Oates, Alexandra, Kumar, Amit, Pinese, Mark, Nagabushan, Sumanth, Lau, Loretta, Ludlow, Louise E., Gifford, Andrew J., Rodriguez, Michael, Desai, Jayesh, Fox, Stephen B., Haber, Michelle, Ziegler, David S., Hansford, Jordan R., Marshall, Glenn M., Cowley, Mark J., Ekert, Paul G.
Publicado 2020

Precision Medicine Is Changing the Roles of Healthcare Professionals, Scientists, and Research Staff: Learnings from a Childhood Cancer Precision Medicine Trial

por Daly, Rebecca, Hetherington, Kate, Hazell, Emily, Wadling, Bethany R., Tyrrell, Vanessa, Tucker, Katherine M., Marshall, Glenn M., Ziegler, David S., Lau, Loretta M. S., Trahair, Toby N., O’Brien, Tracey A., Collins, Kiri, Gifford, Andrew J., Haber, Michelle, Pinese, Mark, Malkin, David, Cowley, Mark J., Karpelowsky, Jonathan, Drew, Donna, Jacobs, Chris, Wakefield, Claire E.
Publicado 2023

Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes

por Ajuyah, Pamela, Mayoh, Chelsea, Lau, Loretta M. S., Barahona, Paulette, Wong, Marie, Chambers, Hazel, Valdes-Mora, Fatima, Senapati, Akanksha, Gifford, Andrew J., D’Arcy, Colleen, Hansford, Jordan R., Manoharan, Neevika, Nicholls, Wayne, Williams, Molly M., Wood, Paul J., Cowley, Mark J., Tyrrell, Vanessa, Haber, Michelle, Ekert, Paul G., Ziegler, David S., Khuong-Quang, Dong-Anh
Publicado 2023

Telomere sequence content can be used to determine ALT activity in tumours

por Lee, Michael, Teber, Erdahl T, Holmes, Oliver, Nones, Katia, Patch, Ann-Marie, Dagg, Rebecca A, Lau, Loretta M S, Lee, Joyce H, Napier, Christine E, Arthur, Jonathan W, Grimmond, Sean M, Hayward, Nicholas K, Johansson, Peter A, Mann, Graham J, Scolyer, Richard A, Wilmott, James S, Reddel, Roger R, Pearson, John V, Waddell, Nicola, Pickett, Hilda A
Publicado 2018

Protocol for a comprehensive prospective cohort study of trio-based whole-genome sequencing for underlying cancer predisposition in paediatric and adolescent patients newly diagnos...

por Fuentes Bolanos, Noemi Auxiliadora, Padhye, Bhavna, Daley, Macabe, Hunter, Jacqueline, Hetherington, Kate, Warby, Meera, Courtney, Eliza, Kirk, Judy, Josephi-Taylor, Sarah, Chen, Yuyan, Alvaro, Frank, Barlow-Stewart, Kristine, Wong-Erasmus, Marie, Barahona, Paulette, Ajuyah, Pamela, Altekoester, Ann-Kristin, Tyrrell, Vanessa J, Lau, Loretta M S, Wakefield, Claire, Sylvester, Dianne, Tucker, Katherine, Pinese, Mark, Dalla Pozza, Luciano, O’Brien, Tracey A
Publicado 2023

DIPG-75. PRECISION MEDICINE FOR PAEDIATRIC HIGH-GRADE DIFFUSE MIDLINE GLIOMAS - RESULTS FROM THE ZERO CHILDHOOD CANCER COMPREHENSIVE PRECISION MEDICINE PROGRAM

por Khuong-Quang, Dong-Anh, Nagabushan, Sumanth, Manoharan, Neevika, Arndt, Greg, Barahona, Paulette, Cowley, Mark J, Ekert, Paul G, Failes, Tim, Bolanos, Noemi Fuentes, Gauthier, Maely, Gifford, Andrew J, Haber, Michelle, Kumar, Amit, Lock, Richard B, Marshall, Glenn M, Mayoh, Chelsea, Mould, Emily, Norris, Murray D, Gopalakrishnan, Anjana, Omer, Natacha, Trebilcock, Peter, Trahair, Toby N, Tsoli, Maria, Tucker, Katherine, Wong, Marie, Tyrrell, Vanessa, Lau, Loretta, S, Ziegler, David
Publicado 2020

High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer

por Mayoh, Chelsea, Mao, Jie, Xie, Jinhan, Tax, Gabor, Chow, Shu-Oi, Cadiz, Roxanne, Pazaky, Karina, Barahona, Paulette, Ajuyah, Pamela, Trebilcock, Peter, Malquori, Angela, Gunther, Kate, Avila, Anica, Yun, Doo Young, Alfred, Stephanie, Gopalakrishnan, Anjana, Kamili, Alvin, Wong, Marie, Cowley, Mark J., Jessop, Sophie, Lau, Loretta M.S., Trahair, Toby N., Ziegler, David S., Fletcher, Jamie I., Gifford, Andrew J., Tsoli, Maria, Marshall, Glenn M., Haber, Michelle, Tyrrell, Vanessa, Failes, Timothy W., Arndt, Greg M., Lock, Richard B., Ekert, Paul G., Dolman, M. Emmy M.
Publicado 2023