COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease

por Kronenberger, Thales, Laufer, Stefan A., Pillaiyar, Thanigaimalai
Publicado 2023

N-[3-(5-Oxo-10,11-dihydro-5H-dibenzo[a,d]cyclo­hepten-2-ylamino)phen­yl]furan-3-carboxamide

por Dorn, Angelika, Schollmeyer, Dieter, Laufer, Stefan A.
Publicado 2010

1-[4-(2-Amino­anilino)phen­yl]-2,2,2-trifluoro­ethanone

por Dorn, Angelika, Schollmeyer, Dieter, Laufer, Stefan A.
Publicado 2010

N-{2-Methyl-5-[(5-oxo-10,11-dihydro-5H-dibenzo[a,d]cyclo­hepten-2-yl)amino]­phen­yl}benzamide

por Dorn, Angelika, Schollmeyer, Dieter, Laufer, Stefan A.
Publicado 2010

Anticancer Drug Conjugates Incorporating Estrogen Receptor Ligands

por Zlotos, Darius P., Kronenberger, Thales, Laufer, Stefan A.
Publicado 2022

A Diverse and Versatile Regiospecific Synthesis of Tetrasubstituted Alkylsulfanylimidazoles as p38α Mitogen-Activated Protein Kinase Inhibitors

por Ansideri, Francesco, Andreev, Stanislav, Kuhn, Annette, Albrecht, Wolfgang, Laufer, Stefan A., Koch, Pierre
Publicado 2018

Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors

por Pantsar, Tatu, Kaiser, Philipp D., Kudolo, Mark, Forster, Michael, Rothbauer, Ulrich, Laufer, Stefan A.
Publicado 2022

Entada africana fraction CH(2)Cl(2)/MEOH 5% inhibits inducible nitric oxide synthase and pro-inflammatory cytokines gene expression induced by lipopolysaccharide in microglia

por Owona, Brice Ayissi, Njayou, Nico Frederic, Laufer, Stefan A, Schluesener, Hermann J, Moundipa, Paul Fewou
Publicado 2013

2-(3-{(3R,4R)-4-Methyl-3-[meth­yl(7H-pyrrolo­[2,3-d]pyrimidin-4-yl)amino]­piperidin-1-yl}oxetan-3-yl)aceto­nitrile monohydrate

por Gehringer, Matthias, Pfaffenrot, Ellen, Keck, Peter R. W. E. F., Schollmeyer, Dieter, Laufer, Stefan A.
Publicado 2014

Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist

por Rashidian, Azam, Mustonen, Enni-Kaisa, Kronenberger, Thales, Schwab, Matthias, Burk, Oliver, Laufer, Stefan A., Pantsar, Tatu
Publicado 2022

Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3β Inhibitors

por Andreev, Stanislav, Pantsar, Tatu, Ansideri, Francesco, Kudolo, Mark, Forster, Michael, Schollmeyer, Dieter, Laufer, Stefan A., Koch, Pierre
Publicado 2019

Discovery of Polyphenolic Natural Products as SARS-CoV-2 M(pro) Inhibitors for COVID-19

por Krüger, Nadine, Kronenberger, Thales, Xie, Hang, Rocha, Cheila, Pöhlmann, Stefan, Su, Haixia, Xu, Yechun, Laufer, Stefan A., Pillaiyar, Thanigaimalai
Publicado 2023

Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket

por Forster, Michael, Chaikuad, Apirat, Bauer, Silke M., Holstein, Julia, Robers, Matthew B., Corona, Cesear R., Gehringer, Matthias, Pfaffenrot, Ellen, Ghoreschi, Kamran, Knapp, Stefan, Laufer, Stefan A.
Publicado 2016

Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3

por Ansideri, Francesco, Macedo, Joana T., Eitel, Michael, El-Gokha, Ahmed, Zinad, Dhafer S., Scarpellini, Camilla, Kudolo, Mark, Schollmeyer, Dieter, Boeckler, Frank M., Blaum, Bärbel S., Laufer, Stefan A., Koch, Pierre
Publicado 2018

Discovery of Novel Orally Active Anti-Inflammatory N-Phenylpyrazolyl-N-Glycinyl-Hydrazone Derivatives That Inhibit TNF-α Production

por Lacerda, Renata B., da Silva, Leandro L., de Lima, Cleverton K. F., Miguez, Eduardo, Miranda, Ana Luisa P., Laufer, Stefan A., Barreiro, Eliezer J., Fraga, Carlos A. M.
Publicado 2012

Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability

por Andreev, Stanislav, Pantsar, Tatu, El-Gokha, Ahmed, Ansideri, Francesco, Kudolo, Mark, Anton, Débora Bublitz, Sita, Giulia, Romasco, Jenny, Geibel, Christian, Lämmerhofer, Michael, Goettert, Márcia Ines, Tarozzi, Andrea, Laufer, Stefan A., Koch, Pierre
Publicado 2020