In Silico Drug Design and Discovery: Big Data for Small Molecule Design

por Cerchia, Carmen, Lavecchia, Antonio
Publicado 2022

Exploring Structural Relationships between Bioactive and Commercial Chemical Space and Developing Target Hypotheses for Compound Acquisition

por Cerchia, Carmen, Dimova, Dilyana, Lavecchia, Antonio, Bajorath, Jürgen
Publicado 2017

Therapeutic Targeting the Cell Division Cycle 25 (CDC25) Phosphatases in Human Acute Myeloid Leukemia — The Possibility to Target Several Kinases through Inhibition of the Various...

por Brenner, Annette K., Reikvam, Håkon, Lavecchia, Antonio, Bruserud, Øystein
Publicado 2014

Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme

por Rullo, Rosario, Cerchia, Carmen, Nasso, Rosarita, Romanelli, Virgilio, Vendittis, Emmanuele De, Masullo, Mariorosario, Lavecchia, Antonio
Publicado 2023

CDC25 Inhibition in Acute Myeloid Leukemia–A Study of Patient Heterogeneity and the Effects of Different Inhibitors

por Brenner, Annette K., Reikvam, Håkon, Rye, Kristin Paulsen, Hagen, Karen Marie, Lavecchia, Antonio, Bruserud, Øystein
Publicado 2017

Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode

por Capelli, Davide, Cerchia, Carmen, Montanari, Roberta, Loiodice, Fulvio, Tortorella, Paolo, Laghezza, Antonio, Cervoni, Laura, Pochetti, Giorgio, Lavecchia, Antonio
Publicado 2016

Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists

por Sabatino, Lina, Ziccardi, Pamela, Cerchia, Carmen, Muccillo, Livio, Piemontese, Luca, Loiodice, Fulvio, Colantuoni, Vittorio, Lupo, Angelo, Lavecchia, Antonio
Publicado 2019

APP Maturation and Intracellular Localization Are Controlled by a Specific Inhibitor of 37/67 kDa Laminin-1 Receptor in Neuronal Cells

por Bhattacharya, Antaripa, Limone, Adriana, Napolitano, Filomena, Cerchia, Carmen, Parisi, Silvia, Minopoli, Giuseppina, Montuori, Nunzia, Lavecchia, Antonio, Sarnataro, Daniela
Publicado 2020

In Silico Identification of Novel Inhibitors Targeting the Homodimeric Interface of Superoxide Dismutase from the Dental Pathogen Streptococcus mutans

por Cerchia, Carmen, Roscetto, Emanuela, Nasso, Rosarita, Catania, Maria Rosaria, De Vendittis, Emmanuele, Lavecchia, Antonio, Masullo, Mariorosario, Rullo, Rosario
Publicado 2022

The 37/67kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67kDa LR cell surface localization and interaction with the cellular prion protein

por Sarnataro, Daniela, Pepe, Anna, Altamura, Gennaro, De Simone, Imma, Pesapane, Ada, Nitsch, Lucio, Montuori, Nunzia, Lavecchia, Antonio, Zurzolo, Chiara
Publicado 2016

Impairment of Nucleolin Activity and Phosphorylation by a Trachylobane Diterpene from Psiadia punctulata in Cancer Cells

por Bellone, Maria Laura, Fiengo, Lorenzo, Cerchia, Carmen, Cotugno, Roberta, Bader, Ammar, Lavecchia, Antonio, De Tommasi, Nunziatina, Piaz, Fabrizio Dal
Publicado 2022

Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion

por Pesapane, Ada, Di Giovanni, Carmen, Rossi, Francesca Wanda, Alfano, Daniela, Formisano, Luigi, Ragno, Pia, Selleri, Carmine, Montuori, Nunzia, Lavecchia, Antonio
Publicado 2015

Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells

por Capasso, Alessandra, Cerchia, Carmen, Di Giovanni, Carmen, Granato, Giuseppina, Albano, Francesco, Romano, Simona, De Vendittis, Emmanuele, Ruocco, Maria Rosaria, Lavecchia, Antonio
Publicado 2015

Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by o...

por Aliotta, Federica, Nasso, Rosarita, Rullo, Rosario, Arcucci, Alessandro, Avagliano, Angelica, Simonetti, Martina, Sanità, Gennaro, Masullo, Mariorosario, Lavecchia, Antonio, Ruocco, Maria Rosaria, Vendittis, Emmanuele De
Publicado 2020

A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability

por Vasaturo, Michele, Fiengo, Lorenzo, De Tommasi, Nunziatina, Sabatino, Lina, Ziccardi, Pamela, Colantuoni, Vittorio, Bruno, Maurizio, Cerchia, Carmen, Novellino, Ettore, Lupo, Angelo, Lavecchia, Antonio, Piaz, Fabrizio Dal
Publicado 2017

Activation of Non-Canonical Autophagic Pathway through Inhibition of Non-Integrin Laminin Receptor in Neuronal Cells

por Limone, Adriana, Veneruso, Iolanda, Izzo, Antonella, Renna, Maurizio, Bonavita, Raffaella, Piscitelli, Silvia, Calì, Gaetano, De Nicola, Sergio, Riccio, Patrizia, D’Argenio, Valeria, Lavecchia, Antonio, Sarnataro, Daniela
Publicado 2022

Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes

por Yasmin, Sabina, Capone, Fabio, Laghezza, Antonio, Piaz, Fabrizio Dal, Loiodice, Fulvio, Vijayan, Viswanathan, Devadasan, Velmurugan, Mondal, Susanta K., Atlı, Özlem, Baysal, Merve, Pattnaik, Ashok K., Jayaprakash, Venkatesan, Lavecchia, Antonio
Publicado 2017

N-Formyl Peptide Receptors Induce Radical Oxygen Production in Fibroblasts Derived From Systemic Sclerosis by Interacting With a Cleaved Form of Urokinase Receptor

por Napolitano, Filomena, Rossi, Francesca Wanda, Pesapane, Ada, Varricchio, Silvia, Ilardi, Gennaro, Mascolo, Massimo, Staibano, Stefania, Lavecchia, Antonio, Ragno, Pia, Selleri, Carmine, Marone, Gianni, Matucci-Cerinic, Marco, de Paulis, Amato, Montuori, Nunzia
Publicado 2018

Inhibition of 37/67kDa Laminin-1 Receptor Restores APP Maturation and Reduces Amyloid-β in Human Skin Fibroblasts from Familial Alzheimer’s Disease

por Bhattacharya, Antaripa, Izzo, Antonella, Mollo, Nunzia, Napolitano, Filomena, Limone, Adriana, Margheri, Francesca, Mocali, Alessandra, Minopoli, Giuseppina, Lo Bianco, Alessandra, Di Maggio, Federica, D’Argenio, Valeria, Montuori, Nunzia, Lavecchia, Antonio, Sarnataro, Daniela
Publicado 2020

Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies

por Ammazzalorso, Alessandra, Bruno, Isabella, Florio, Rosalba, De Lellis, Laura, Laghezza, Antonio, Cerchia, Carmen, De Filippis, Barbara, Fantacuzzi, Marialuigia, Giampietro, Letizia, Maccallini, Cristina, Tortorella, Paolo, Veschi, Serena, Loiodice, Fulvio, Lavecchia, Antonio, Cama, Alessandro, Amoroso, Rosa
Publicado 2020