Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer’s disease

por Lavekar, Sailee S., Harkin, Jade, Hernandez, Melody, Gomes, Cátia, Patil, Shruti, Huang, Kang-Chieh, Puntambekar, Shweta S., Lamb, Bruce T., Meyer, Jason S.
Publicado 2023

Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids

por Fligor, Clarisse M., Lavekar, Sailee S., Harkin, Jade, Shields, Priya K., VanderWall, Kirstin B., Huang, Kang-Chieh, Gomes, Cátia, Meyer, Jason S.
Publicado 2021

Autophagy disruption reduces mTORC1 activation leading to retinal ganglion cell neurodegeneration associated with glaucoma

por Huang, Kang-Chieh, Gomes, Cátia, Shiga, Yukihiro, Belforte, Nicolas, VanderWall, Kirstin B., Lavekar, Sailee S., Fligor, Clarisse M., Harkin, Jade, Di Polo, Adriana, Meyer, Jason S.
Publicado 2023

Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells

por Gomes, Cátia, VanderWall, Kirstin B., Pan, Yanling, Lu, Xiaoyu, Lavekar, Sailee S., Huang, Kang-Chieh, Fligor, Clarisse M., Harkin, Jade, Zhang, Chi, Cummins, Theodore R., Meyer, Jason S.
Publicado 2022

Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids

por VanderWall, Kirstin B., Huang, Kang-Chieh, Pan, Yanling, Lavekar, Sailee S., Fligor, Clarisse M., Allsop, Anna R., Lentsch, Kelly A., Dang, Pengtao, Zhang, Chi, Tseng, Henry C., Cummins, Theodore R., Meyer, Jason S.
Publicado 2020