Blockade of ACK1/TNK2 To Squelch the Survival of Prostate Cancer Stem-like Cells

por Mahajan, Nupam P., Coppola, Domenico, Kim, Jongphil, Lawrence, Harshani R., Lawrence, Nicholas J., Mahajan, Kiran
Publicado 2018

Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC

por Alhothali, Marwa, Mathew, Mevin, Iyer, Geeta, Lawrence, Harshani R., Yang, Shengyu, Chellappan, Srikumar, Padmanabhan, Jaya
Publicado 2019

Lysophosphatidic Acid Acyltransferase Beta Regulates mTOR Signaling

por Blaskovich, Michelle A., Yendluri, Vimala, Lawrence, Harshani R., Lawrence, Nicholas J., Sebti, Saïd M., Springett, Gregory M.
Publicado 2013

The Novel Positive Allosteric Modulator of the GABA(B) Receptor, KK-92A, Suppresses Alcohol Self-Administration and Cue-Induced Reinstatement of Alcohol Seeking in Rats

por Maccioni, Paola, Kaczanowska, Katarzyna, Lawrence, Harshani, Yun, Sang, Bratzu, Jessica, Gessa, Gian Luigi, McDonald, Patricia, Colombo, Giancarlo
Publicado 2021

P-115: Unc-51 Like Kinase 3 protein (ULK3)-mediated autophagy is responsible for multiple myeloma resistance to chemotherapy

por Tauro, Marilena, Li, Tao, Meads, Mark, Sudalagunta, Praneeth, Alugubelli, Raghunandan Reddy, Lawrence, Nicholas, Schonbrunn, Ernst, Lawrence, Harshani, Shain, Kenneth, Lynch, Conor
Publicado 2022

Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation

por Yang, Hua, Lawrence, Harshani R., Kazi, Aslamuzzaman, Gevariya, Harsukh, Patel, Ronil, Luo, Yunting, Rix, Uwe, Schonbrunn, Ernst, Lawrence, Nicholas J., Sebti, Said M.
Publicado 2014

GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

por Kazi, Aslamuzzaman, Xiang, Shengyan, Yang, Hua, Delitto, Daniel, Trevino, José, Jiang, Rays H. Y., Ayaz, Muhammad, Lawrence, Harshani R., Kennedy, Perry, Sebti, Saïd M.
Publicado 2018

Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer

por McGuire, Jeremy J., Frieling, Jeremy S., Lo, Chen Hao, Li, Tao, Muhammad, Ayaz, Lawrence, Harshani R., Lawrence, Nicholas J., Cook, Leah M., Lynch, Conor C.
Publicado 2021

Dabrafenib inhibits the growth of BRAF‐WT cancers through CDK16 and NEK9 inhibition

por Phadke, Manali, Remsing Rix, Lily L., Smalley, Inna, Bryant, Annamarie T., Luo, Yunting, Lawrence, Harshani R., Schaible, Braydon J., Chen, Yian A., Rix, Uwe, Smalley, Keiran S. M.
Publicado 2017

Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma

por Schneeberger, Valentina E., Ren, Yuan, Luetteke, Noreen, Huang, Qingling, Chen, Liwei, Lawrence, Harshani R., Lawrence, Nicholas J., Haura, Eric B., Koomen, John M., Coppola, Domenico, Wu, Jie
Publicado 2015

Integrated proteomics identifies PARP inhibitor-induced prosurvival signaling changes as potential vulnerabilities in ovarian cancer

por Deng, Ou, Dash, Sweta, Nepomuceno, Thales C., Fang, Bin, Yun, Sang Y., Welsh, Eric A., Lawrence, Harshani R., Marchion, Douglas, Koomen, John M., Monteiro, Alvaro N., Rix, Uwe
Publicado 2022

TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate

por Hesterberg, Rebecca S., Liu, Min, Elmarsafawi, Aya G., Koomen, John M., Welsh, Eric A., Hesterberg, Stephen G., Ranatunga, Sujeewa, Yang, Chunying, Li, Weimin, Lawrence, Harshani R., Rodriguez, Paulo C., Berglund, Anders E., Cleveland, John L.
Publicado 2022

Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting

por Sawant, Mithila, Mahajan, Kiran, Renganathan, Arun, Weimholt, Cody, Luo, Jingqin, Kukshal, Vandna, Jez, Joseph M., Jeon, Myung Sik, Zhang, Bo, Li, Tiandao, Fang, Bin, Luo, Yunting, Lawrence, Nicholas J., Lawrence, Harshani R., Feng, Felix Y., Mahajan, Nupam P.
Publicado 2022