Understanding insulin and its receptor from their three-dimensional structures

por Lawrence, Michael C.
Publicado 2021

Landmarks in Insulin Research

por Ward, Colin W., Lawrence, Michael C.
Publicado 2011

Vale Colin Ward—A Leader in Receptor Structural Biology

por Lawrence, Michael C., Colman, Peter M.
Publicado 2017

MicroRNA Signatures as Future Biomarkers for Diagnosis of Diabetes States

por Vasu, Srividya, Kumano, Kenjiro, Darden, Carly M., Rahman, Irum, Lawrence, Michael C., Naziruddin, Bashoo
Publicado 2019

Role of Exosomes in Islet Transplantation

por Mattke, Jordan, Vasu, Srividya, Darden, Carly M., Kumano, Kenjiro, Lawrence, Michael C., Naziruddin, Bashoo
Publicado 2021

Inflammatory Response in Islet Transplantation

por Kanak, Mazhar A., Takita, Morihito, Kunnathodi, Faisal, Lawrence, Michael C., Levy, Marlon F., Naziruddin, Bashoo
Publicado 2014

Clinical and biological significance of circulating miRNAs in chronic pancreatitis patients undergoing total pancreatectomy with islet autotransplantation

por Vasu, Srividya, Saracino, Giovanna, Darden, Carly M., Kumano, Kenjiro, Liu, Yang, Lawrence, Michael C., Naziruddin, Bashoo
Publicado 2023

Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress

por Darden, Carly M., Vasu, Srividya, Mattke, Jordan, Liu, Yang, Rhodes, Christopher J., Naziruddin, Bashoo, Lawrence, Michael C.
Publicado 2022

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

por Chen, Lin, Xu, Yibin, Healer, Julie, Thompson, Jenny K, Smith, Brian J, Lawrence, Michael C, Cowman, Alan F
Publicado 2014

A Molecular Mechanism for Bacterial Susceptibility to Zinc

por McDevitt, Christopher A., Ogunniyi, Abiodun D., Valkov, Eugene, Lawrence, Michael C., Kobe, Bostjan, McEwan, Alastair G., Paton, James C.
Publicado 2011

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

por Chen, Lin, Xu, Yibin, Wong, Wilson, Thompson, Jennifer K, Healer, Julie, Goddard-Borger, Ethan D, Lawrence, Michael C, Cowman, Alan F
Publicado 2017

How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor

por Xu, Yibin, Margetts, Mai B., Venugopal, Hari, Menting, John G., Kirk, Nicholas S., Croll, Tristan I., Delaine, Carlie, Forbes, Briony E., Lawrence, Michael C.
Publicado 2022

Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity

por van Lierop, Bianca, Ong, Shee Chee, Belgi, Alessia, Delaine, Carlie, Andrikopoulos, Sofianos, Haworth, Naomi L., Menting, John G., Lawrence, Michael C., Robinson, Andrea J., Forbes, Briony E.
Publicado 2017

How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor

por Xu, Yibin, Kirk, Nicholas S., Venugopal, Hariprasad, Margetts, Mai B., Croll, Tristan I., Sandow, Jarrod J., Webb, Andrew I., Delaine, Carlie A., Forbes, Briony E., Lawrence, Michael C.
Publicado 2020

The signalling conformation of the insulin receptor ectodomain

por Weis, Felix, Menting, John G., Margetts, Mai B., Chan, Shu Jin, Xu, Yibin, Tennagels, Norbert, Wohlfart, Paulus, Langer, Thomas, Müller, Christoph W., Dreyer, Matthias K., Lawrence, Michael C.
Publicado 2018

Pancreatic β-Cell–Derived IP-10/CXCL10 Isletokine Mediates Early Loss of Graft Function in Islet Cell Transplantation

por Yoshimatsu, Gumpei, Kunnathodi, Faisal, Saravanan, Prathab Balaji, Shahbazov, Rauf, Chang, Charles, Darden, Carly M., Zurawski, Sandra, Boyuk, Gulbahar, Kanak, Mazhar A., Levy, Marlon F., Naziruddin, Bashoo, Lawrence, Michael C.
Publicado 2017

How ligand binds to the type 1 insulin-like growth factor receptor

por Xu, Yibin, Kong, Geoffrey K.-W., Menting, John G., Margetts, Mai B., Delaine, Carlie A., Jenkin, Lauren M., Kiselyov, Vladislav V., De Meyts, Pierre, Forbes, Briony E., Lawrence, Michael C.
Publicado 2018

Insertion of a Synthetic Switch Into Insulin Provides Metabolite-Dependent Regulation of Hormone-Receptor Activation

por Chen, Yen-Shan, Gleaton, Jeremy, Yang, Yanwu, Dhayalan, Balamurugan, Phillips, Nelson B, Liu, Yule, Broadwater, Laurie, Jarosinski, Mark, Chatterjee, Deepak, Lawrence, Michael C, Hattier, Thomas, Michael, Dodson M, Weiss, Michael Aaron
Publicado 2021

Activation of the human insulin receptor by non-insulin-related peptides

por Kirk, Nicholas S., Chen, Qi, Wu, Yingzhe Ginger, Asante, Anastasia L., Hu, Haitao, Espinosa, Juan F., Martínez-Olid, Francisco, Margetts, Mai B., Mohammed, Faiz A., Kiselyov, Vladislav V., Barrett, David G., Lawrence, Michael C.
Publicado 2022

Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

por Moreau, Francois, Kirk, Nicholas S., Zhang, Fa, Gelfanov, Vasily, List, Edward O., Chrudinová, Martina, Venugopal, Hari, Lawrence, Michael C., Jimenez, Veronica, Bosch, Fatima, Kopchick, John J., DiMarchi, Richard D., Altindis, Emrah, Kahn, C. Ronald
Publicado 2022