Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics

por Cossins, Benjamin P., Lawson, Alastair D. G.
Publicado 2015

A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers

por Heads, James T., Kelm, Sebastian, Tyson, Kerry, Lawson, Alastair D. G.
Publicado 2022

Natural Conformational Sampling of Human TNFα Visualized by Double Electron-Electron Resonance

por Carrington, Bruce, Myers, William K., Horanyi, Peter, Calmiano, Mark, Lawson, Alastair D.G.
Publicado 2017

Rings in Clinical Trials and Drugs: Present and Future

por Shearer, Jonathan, Castro, Jose L., Lawson, Alastair D. G., MacCoss, Malcolm, Taylor, Richard D.
Publicado 2022

Creation of a gated antibody as a conditionally functional synthetic protein

por Gunnoo, Smita B., Finney, Helene M., Baker, Terry S., Lawson, Alastair D., Anthony, Daniel C., Davis, Benjamin G.
Publicado 2014

Modulating Target Protein Biology Through the Re-mapping of Conformational Distributions Using Small Molecules

por Lawson, Alastair D. G., MacCoss, Malcolm, Baeten, Dominique L., Macpherson, Alex, Shi, Jiye, Henry, Alistair J.
Publicado 2021

Functional inhibition of β-catenin-mediatedWnt signaling by intracellular VHHantibodies

por Newnham, Laura E, Wright, Michael J, Holdsworth, Gill, Kostarelos, Kostas, Robinson, Martyn K, Rabbitts, Terence H, Lawson, Alastair D
Publicado 2014

Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping

por Liu, Xiaofeng, Taylor, Richard D., Griffin, Laura, Coker, Shu-Fen, Adams, Ralph, Ceska, Tom, Shi, Jiye, Lawson, Alastair D. G., Baker, Terry
Publicado 2017

The rational design of affinity-attenuated OmCI for the purification of complement C5

por Macpherson, Alex, Liu, Xiaofeng, Dedi, Neesha, Kennedy, Jeffery, Carrington, Bruce, Durrant, Oliver, Heywood, Sam, van den Elsen, Jean, Lawson, Alastair D. G.
Publicado 2018

Electrostatic interactions modulate the differential aggregation propensities of IgG1 and IgG4P antibodies and inform charged residue substitutions for improved developability

por Heads, James T, Lamb, Richard, Kelm, Sebastian, Adams, Ralph, Elliott, Peter, Tyson, Kerry, Topia, Sarfaraj, West, Shauna, Nan, Ruodan, Turner, Alison, Lawson, Alastair D G
Publicado 2019

Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F

por Adams, Ralph, Maroof, Asher, Baker, Terry, Lawson, Alastair D. G., Oliver, Ruth, Paveley, Ross, Rapecki, Steve, Shaw, Stevan, Vajjah, Pavan, West, Shauna, Griffiths, Meryn
Publicado 2020

The proximity of the N- and C- termini of bovine knob domains enable engineering of target specificity into polypeptide chains

por Hawkins, Alice, Joyce, Callum, Brady, Kevin, Hold, Adam, Smith, Alan, Knight, Michael, Howard, Conor, van den Elsen, Jean, Lawson, Alastair D.G., Macpherson, Alex
Publicado 2022

Isolation of antigen-specific, disulphide-rich knob domain peptides from bovine antibodies

por Macpherson, Alex, Scott-Tucker, Anthony, Spiliotopoulos, Anastasios, Simpson, Catherine, Staniforth, Justin, Hold, Adam, Snowden, James, Manning, Leah, van den Elsen, Jean, Lawson, Alastair D. G.
Publicado 2020

Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

por McMillan, David, Martinez-Fleites, Carlos, Porter, John, Fox, David, Davis, Rachel, Mori, Prashant, Ceska, Tom, Carrington, Bruce, Lawson, Alastair, Bourne, Tim, O’Connell, James
Publicado 2021

Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum hal...

por Adams, Ralph, Griffin, Laura, Compson, Joanne E., Jairaj, Mark, Baker, Terry, Ceska, Tom, West, Shauna, Zaccheo, Oliver, Davé, Emma, Lawson, Alastair DG., Humphreys, David P., Heywood, Sam
Publicado 2016

Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling

por Shaw, Stevan, Bourne, Tim, Meier, Chris, Carrington, Bruce, Gelinas, Rich, Henry, Alistair, Popplewell, Andrew, Adams, Ralph, Baker, Terry, Rapecki, Steve, Marshall, Diane, Moore, Adrian, Neale, Helen, Lawson, Alastair
Publicado 2014

Identification and characterisation of anti-IL-13 inhibitory single domain antibodies provides new insights into receptor selectivity and attractive opportunities for drug discover...

por Walker, Kayleigh, Baravalle, Roberta, Holyfield, Rachel, Kalms, Jacqueline, Wright, Helena, Seewooruthun, Chitra, Muskett, Frederick W., Scott-Tucker, Anthony, Merritt, Andy, Henry, Alistair, Lawson, Alastair D. G., Hall, Gareth, Prosser, Christine, Carr, Mark D.
Publicado 2023

Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F co...

por Glatt, Sophie, Baeten, Dominique, Baker, Terry, Griffiths, Meryn, Ionescu, Lucian, Lawson, Alastair D G, Maroof, Ash, Oliver, Ruth, Popa, Serghei, Strimenopoulou, Foteini, Vajjah, Pavan, Watling, Mark I L, Yeremenko, Nataliya, Miossec, Pierre, Shaw, Stevan
Publicado 2018

A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF

por Lightwood, Daniel J., Munro, Rebecca J., Porter, John, McMillan, David, Carrington, Bruce, Turner, Alison, Scott-Tucker, Anthony, Hickford, Elizabeth S., Schmidt, Antje, Fox, David, Maloney, Alison, Ceska, Tom, Bourne, Tim, O’Connell, James, Lawson, Alastair D. G.
Publicado 2021

Serum albumin binding knob domains engineered within a V(H) framework III bispecific antibody format and as chimeric peptides

por Adams, Ralph, Joyce, Callum, Kuravskiy, Mikhail, Harrison, Katriona, Ahdash, Zainab, Balmforth, Matthew, Chia, Kelda, Marceddu, Cinzia, Coates, Matthew, Snowden, James, Goursaud, Emmanuel, Ménochet, Karelle, van den Elsen, Jean, Payne, Richard J., Lawson, Alastair D. G., Scott-Tucker, Anthony, Macpherson, Alex
Publicado 2023