Human β-defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate–mediated membrane permeabilization

por Järvå, Michael, Phan, Thanh Kha, Lay, Fung T., Caria, Sofia, Kvansakul, Marc, Hulett, Mark D.
Publicado 2018

Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics

por Hein, Matthew J. A., Kvansakul, Marc, Lay, Fung T., Phan, Thanh Kha, Hulett, Mark D.
Publicado 2022

Human β-defensin 3 contains an oncolytic motif that binds PI(4,5)P(2) to mediate tumour cell permeabilisation

por Phan, Thanh Kha, Lay, Fung T., Poon, Ivan K.H., Hinds, Mark G., Kvansakul, Marc, Hulett, Mark D.
Publicado 2015

Human β-Defensin 2 (HBD-2) Displays Oncolytic Activity but Does Not Affect Tumour Cell Migration

por Bindra, Guneet K., Williams, Scott A., Lay, Fung T., Baxter, Amy A., Poon, Ivan K. H., Hulett, Mark D., Phan, Thanh Kha
Publicado 2022

Crocodile defensin (CpoBD13) antifungal activity via pH-dependent phospholipid targeting and membrane disruption

por Williams, Scott A., Lay, Fung T., Bindra, Guneet K., Banjara, Suresh, Poon, Ivan K. H., Phan, Thanh Kha, Kvansakul, Marc, Hulett, Mark D.
Publicado 2023

X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex

por Järvå, Michael, Lay, Fung T., Phan, Thanh Kha, Humble, Cassandra, Poon, Ivan K. H., Bleackley, Mark R., Anderson, Marilyn A., Hulett, Mark D., Kvansakul, Marc
Publicado 2018

The C-terminal propeptide of a plant defensin confers cytoprotective and subcellular targeting functions

por Lay, Fung T, Poon, Simon, McKenna, James A, Connelly, Angela A, Barbeta, Barbara L, McGinness, Bruce S, Fox, Jennifer L, Daly, Norelle L, Craik, David J, Heath, Robyn L, Anderson, Marilyn A
Publicado 2014

Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

por Poon, Ivan KH, Baxter, Amy A, Lay, Fung T, Mills, Grant D, Adda, Christopher G, Payne, Jennifer AE, Phan, Thanh Kha, Ryan, Gemma F, White, Julie A, Veneer, Prem K, van der Weerden, Nicole L, Anderson, Marilyn A, Kvansakul, Marc, Hulett, Mark D
Publicado 2014

Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32

por Kerenga, Bomai K., McKenna, James A., Harvey, Peta J., Quimbar, Pedro, Garcia-Ceron, Donovan, Lay, Fung T., Phan, Thanh Kha, Veneer, Prem K., Vasa, Shaily, Parisi, Kathy, Shafee, Thomas M. A., van der Weerden, Nicole L., Hulett, Mark D., Craik, David J., Anderson, Marilyn A., Bleackley, Mark R.
Publicado 2019