Antibody-guided proteases enable selective and catalytic degradation of challenging therapeutic targets

por Romei, Matthew G., Leonard, Brandon, Kim, Ingrid, Kim, Hok Seon, Lazar, Greg A.
Publicado 2023

Avidity in antibody effector functions and biotherapeutic drug design

por Oostindie, Simone C., Lazar, Greg A., Schuurman, Janine, Parren, Paul W. H. I.
Publicado 2022

High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants

por DiCara, Danielle M., Andersen, Nisana, Chan, Ruby, Ernst, James A., Ayalon, Gai, Lazar, Greg A., Agard, Nicholas J., Hilderbrand, Amy, Hötzel, Isidro
Publicado 2018

Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2

por Leonard, Brandon, Sankar, Kannan, Romei, Matthew G., Tse, Margaret J., Do, Nina, Yang, Yanli, Matochko, Wadim L., Bevers, Jack, Bollineni, Sundeep, Mukhyala, Kiran, Hoi, Kam Hon, Lazar, Greg A.
Publicado 2022

Automated high throughput microscale antibody purification workflows for accelerating antibody discovery

por Luan, Peng, Lee, Sophia, Arena, Tia A., Paluch, Maciej, Kansopon, Joe, Viajar, Sharon, Begum, Zahira, Chiang, Nancy, Nakamura, Gerald, Hass, Philip E., Wong, Athena W., Lazar, Greg A., Gill, Avinash
Publicado 2018

Immune suppression in cynomolgus monkeys by XPro9523: An improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn

por Bernett, Matthew J., Chu, Seung Y., Leung, Irene, Moore, Gregory L., Lee, Sung-Hyung, Pong, Erik, Chen, Hsing, Phung, Sheryl, Muchhal, Umesh S., Horton, Holly M., Lazar, Greg A., Desjarlais, John R, Szymkowski, David E.
Publicado 2013

Antibody interfaces revealed through structural mining

por Yin, Yizhou, Romei, Matthew G., Sankar, Kannan, Pal, Lipika R., Hoi, Kam Hon, Yang, Yanli, Leonard, Brandon, De Leon Boenig, Gladys, Kumar, Nikit, Matsumoto, Marissa, Payandeh, Jian, Harris, Seth F., Moult, John, Lazar, Greg A.
Publicado 2022

Targeted IgMs agonize ocular targets with extended vitreal exposure

por Chen, Yvonne, Paluch, Maciej, Zorn, Julie A., Rajan, Sharmila, Leonard, Brandon, Estevez, Alberto, Brady, John, Chiu, Henry, Phung, Wilson, Famili, Amin, Yan, Minhong, Ciferri, Claudio, Matsumoto, Marissa L., Lazar, Greg A., Crowell, Susan, Hass, Phil, Agard, Nicholas J.
Publicado 2020

An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans

por Chung, Shan, Nguyen, Van, Lin, Yuwen Linda, Lafrance-Vanasse, Julien, Scales, Suzie J., Lin, Kevin, Deng, Rong, Williams, Kathi, Sperinde, Gizette, Li, Juan Jenny, Zheng, Kai, Sukumaran, Siddharth, Tesar, Devin, Ernst, James A., Fischer, Saloumeh, Lazar, Greg A., Prabhu, Saileta, Song, An
Publicado 2019

Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members

por Yang, Yanli, Yeh, Sherry H., Madireddi, Shravan, Matochko, Wadim L., Gu, Chen, Pacheco Sanchez, Patricia, Ultsch, Mark, De Leon Boenig, Gladys, Harris, Seth F., Leonard, Brandon, Scales, Suzie J., Zhu, Jing W., Christensen, Erin, Hang, Julie Q., Brezski, Randall J., Marsters, Scot, Ashkenazi, Avi, Sukumaran, Siddharth, Chiu, Henry, Cubas, Rafael, Kim, Jeong M., Lazar, Greg A.
Publicado 2019