Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic Target

por Lazarev, Vladimir F., Guzhova, Irina V., Margulis, Boris A.
Publicado 2020

Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates

por Lazarev, Vladimir F., Mikhaylova, Elena R., Guzhova, Irina V., Margulis, Boris A.
Publicado 2017

Hydrocortisone 21-hemisuccinate did not prevent exogenous GAPDH-induced apoptosis in human neuroblastoma cells

por Lazarev, Vladimir F., Dutysheva, Elizaveta A., Komarova, Elena Y., Guzhova, Irina V., Margulis, Boris A.
Publicado 2018

Protein Interactome of Amyloid-β as a Therapeutic Target

por Lazarev, Vladimir F., Dutysheva, Elizaveta A., Kanunikov, Igor E., Guzhova, Irina V., Margulis, Boris A.
Publicado 2023

Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress

por Mikeladze, Marina A., Dutysheva, Elizaveta A., Kartsev, Victor G., Margulis, Boris A., Guzhova, Irina V., Lazarev, Vladimir F.
Publicado 2021

Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells

por Meshalkina, Darya A., Shevtsov, Maxim A., Dobrodumov, Anatoliy V., Komarova, Elena Y., Voronkina, Irina V., Lazarev, Vladimir F., Margulis, Boris A., Guzhova, Irina V.
Publicado 2016

Indolylazine Derivative Induces Chaperone Expression in Aged Neural Cells and Prevents the Progression of Alzheimer’s Disease

por Lazarev, Vladimir F., Dutysheva, Elizaveta A., Mikhaylova, Elena R., Trestsova, Maria A., Utepova, Irina A., Chupakhin, Oleg N., Margulis, Boris A., Guzhova, Irina V.
Publicado 2022

Dataset of NMR-spectra pyrrolyl- and indolylazines and evidence of their ability to induce heat shock genes expression in human neurons

por Dutysheva, Elizaveta A., Utepova, Irina A., Trestsova, Maria A., Anisimov, Alexander S., Charushin, Valery N., Chupakhin, Oleg N., Margulis, Boris A., Guzhova, Irina V., Lazarev, Vladimir F.
Publicado 2021

Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models

por Lazarev, Vladimir F., Sverchinsky, Dmitry V., Mikhaylova, Elena R., Semenyuk, Pavel I., Komarova, Elena Y., Niskanen, Sergey A., Nikotina, Alina D., Burakov, Anton V., Kartsev, Viktor G., Guzhova, Irina V., Margulis, Boris A.
Publicado 2018

Autocrine regulation of tumor cell repopulation by Hsp70-HMGB1 alarmin complex

por Sverchinsky, Dmitry V., Alhasan, Bashar A., Mikeladze, Marina A., Lazarev, Vladimir F., Kuznetcova, Liubov S., Morshneva, Alisa V., Nikotina, Alina D., Ziewanah, Amr, Koludarova, Lidia V., Starkova, Tatiana Y., Margulis, Boris A., Guzhova, Irina V.
Publicado 2023

Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3

por Sverchinsky, Dmitry V., Nikotina, Alina D., Komarova, Elena Y., Mikhaylova, Elena R., Aksenov, Nikolay D., Lazarev, Vladimir F., Mitkevich, Vladimir A., Suezov, Roman, Druzhilovskiy, Dmitry S., Poroikov, Vladimir V., Margulis, Boris A., Guzhova, Irina V.
Publicado 2018

Properties of substances inhibiting aggregation of oxidized GAPDH: Data on the interaction with the enzyme and the impact on its intracellular content

por Lazarev, Vladimir F., Nikotina, Alina D., Semenyuk, Pavel I., Evstafyeva, Diana B., Mikhaylova, Elena R., Muronetz, Vladimir I., Shevtsov, Maxim A., Tolkacheva, Anastasia V., Dobrodumov, Anatoly V., Shavarda, Alexey L., Guzhova, Irina V., Margulis, Boris A.
Publicado 2016

Pyrrolylquinoxaline-2-One Derivative as a Potent Therapeutic Factor for Brain Trauma Rehabilitation

por Dutysheva, Elizaveta A., Mikeladze, Marina A., Trestsova, Maria A., Aksenov, Nikolay D., Utepova, Irina A., Mikhaylova, Elena R., Suezov, Roman V., Charushin, Valery N., Chupakhin, Oleg N., Guzhova, Irina V., Margulis, Boris A., Lazarev, Vladimir F.
Publicado 2020

Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity

por Lazarev, Vladimir F, Tsolaki, Magda, Mikhaylova, Elena R, Benken, Konstantin A, Shevtsov, Maxim A, Nikotina, Alina D, Lechpammer, Mirna, Mitkevich, Vladimir A, Makarov, Alexander A, Moskalev, Alexey A, Kozin, Sergey A, Margulis, Boris A, Guzhova, Irina V, Nudler, Evgeny
Publicado 2021

Combination of a Chaperone Synthesis Inducer and an Inhibitor of GAPDH Aggregation for Rehabilitation after Traumatic Brain Injury: A Pilot Study

por Dutysheva, Elizaveta A., Mikhaylova, Elena R., Trestsova, Maria A., Andreev, Alexander I., Apushkin, Danila Yu., Utepova, Irina A., Serebrennikova, Polina O., Akhremenko, Eugenia A., Aksenov, Nikolay D., Bon’, Elizaveta I., Zimatkin, Sergey M., Chupakhin, Oleg N., Margulis, Boris A., Guzhova, Irina V., Lazarev, Vladimir F.
Publicado 2022