Cutting down the time to identify challenging tumor therapeutic targets and drug combinations using synthetic lethal approaches

por Lazo, John S.
Publicado 2018

The hubris and humility of cancer pharmacology in the post immuno‐oncology era

por Lazo, John S.
Publicado 2019

Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion

por Wang, Yan, Lazo, John S.
Publicado 2011

Targeted Deletion of the Metastasis-Associated Phosphatase Ptp4a3 (PRL-3) Suppresses Murine Colon Cancer

por Zimmerman, Mark W., Homanics, Gregg E., Lazo, John S.
Publicado 2013

Toward a Molecular Understanding of the Interaction of Dual Specificity Phosphatases with Substrates: Insights from Structure-Based Modeling and High Throughput Screening

por Bakan, Ahmet, Lazo, John S, Wipf, Peter, Brummond, Kay M, Bahar, Ivet
Publicado 2008

Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C(1)

por Xu, Fengfeng L, Rbaibi, Youssef, Kiselyov, Kirill, Lazo, John S, Wipf, Peter, Saunders, William S
Publicado 2010

An acute respiratory distress syndrome drug development collaboration stimulated by the Virginia Drug Discovery Consortium

por Lazo, John S., Colunga-Biancatelli, Ruben M.L., Solopov, Pavel. A., Catravas, John D.
Publicado 2023

Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target

por Zhang, Fang, Rothermund, Kristi, Gangadharan, Sajithlal B., Pommier, Yves, Prochownik, Edward V., Lazo, John S.
Publicado 2012

High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons

por Sharlow, Elizabeth R., Llaneza, Danielle C., Grever, William E., Mingledorff, Garnett A., Mendelson, Anna J., Bloom, George S., Lazo, John S.
Publicado 2023

Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators

por Greenberger, Joel S., Clump, David, Kagan, Valerian, Bayir, Hülya, Lazo, John S., Wipf, Peter, Li, Song, Gao, Xiang, Epperly, Michael W.
Publicado 2012

Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production

por Aguilar-Sopeña, Oscar, Hernández-Pérez, Sara, Alegre-Gómez, Sergio, Castro-Sánchez, Patricia, Iglesias-Ceacero, Alba, Lazo, John S., Roda-Navarro, Pedro
Publicado 2020

Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility

por LaValle, Courtney R, Bravo-Altamirano, Karla, Giridhar, Karthik V, Chen, Jun, Sharlow, Elizabeth, Lazo, John S, Wipf, Peter, Wang, Q Jane
Publicado 2010

Discovery of Diverse Small Molecule Chemotypes with Cell-Based PKD1 Inhibitory Activity

por Sharlow, Elizabeth R., Mustata Wilson, Gabriela, Close, David, Leimgruber, Stephanie, Tandon, Manuj, Reed, Robyn B., Shun, Tong Ying, Wang, Q. Jane, Wipf, Peter, Lazo, John S.
Publicado 2011

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

por Molina, Gabriela, Vogt, Andreas, Bakan, Ahmet, Dai, Weixiang, de Oliveira, Pierre Queiroz, Znosko, Wade, Smithgall, Thomas E., Bahar, Ivet, Lazo, John S., Day, Billy W., Tsang, Michael
Publicado 2009

Identification of Potent Chemotypes Targeting Leishmania major Using a High-Throughput, Low-Stringency, Computationally Enhanced, Small Molecule Screen

por Sharlow, Elizabeth R., Close, David, Shun, Tongying, Leimgruber, Stephanie, Reed, Robyn, Mustata, Gabriela, Wipf, Peter, Johnson, Jacob, O'Neil, Michael, Grögl, Max, Magill, Alan J., Lazo, John S.
Publicado 2009

A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

por Sharlow, Elizabeth R., Lyda, Todd A., Dodson, Heidi C., Mustata, Gabriela, Morris, Meredith T., Leimgruber, Stephanie S., Lee, Kuo-Hsiung, Kashiwada, Yoshiki, Close, David, Lazo, John S., Morris, James C.
Publicado 2010

Design, Synthesis, and Biological Evaluation of PKD Inhibitors

por George, Kara M., Frantz, Marie-Céline, Bravo-Altamirano, Karla, LaValle, Courtney R., Tandon, Manuj, Leimgruber, Stephanie, Sharlow, Elizabeth R., Lazo, John S., Wang, Q. Jane, Wipf, Peter
Publicado 2011

Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer

por Lazo, John S., Sharlow, Elizabeth R., Cornelison, Robert, Hart, Duncan J., Llaneza, Danielle C., Mendelson, Anna J., Rastelli, Ettore J., Tasker, Nikhil R., Landen, Charles N., Wipf, Peter
Publicado 2021

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids

por Wang, Huabo, Teriete, Peter, Hu, Angela, Raveendra-Panickar, Dhanya, Pendelton, Kelsey, Lazo, John S., Eiseman, Julie, Holien, Toril, Misund, Kristine, Oliynyk, Ganna, Arsenian-Henriksson, Marie, Cosford, Nicholas D. P, Sundan, Anders, Prochownik, Edward V.
Publicado 2015

SYST-28 FUNCTIONAL MAPPING REVEALS WIDESPREAD REMODELLING AND A NOVEL TARGETABLE PTP4A2-ROBO1 SIGNALING AXIS AT GLIOBLASTOMA RECURRENCE

por Chokshi, Chirayu, Shaikh, Vaseem, Tieu, David, Brakel, Benjamin, Brown, Kevin, chan, Katherine, rossotti, Martin, Maich, William, Venugopal, Chitra, Anand, Alisha, Lazo, John, Kislinger, Thomas, Lu, Jian, Provias, John, Henry, Kevin, Moffat, Jason, Singh, Sheila
Publicado 2023