Targeting Histone Epigenetic Modifications and DNA Damage Responses in Synthetic Lethality Strategies in Cancer?

por Lazo, Pedro A.
Publicado 2022

VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1

por Monte-Serrano, Eva, Lazo, Pedro A.
Publicado 2023

Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?

por Campillo-Marcos, Ignacio, Lazo, Pedro A.
Publicado 2018

Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase

por Campillo-Marcos, Ignacio, Lazo, Pedro A.
Publicado 2019

VRK1 Depletion Facilitates the Synthetic Lethality of Temozolomide and Olaparib in Glioblastoma Cells

por Navarro-Carrasco, Elena, Lazo, Pedro A.
Publicado 2021

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression

por Valbuena, Alberto, López-Sánchez, Inmaculada, Lazo, Pedro A.
Publicado 2008

JC virus in the pathogenesis of colorectal cancer, an etiological agent or another component in a multistep process?

por Coelho, Tatiana R, Almeida, Luis, Lazo, Pedro A
Publicado 2010

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway

por Valbuena, Alberto, Castro-Obregón, Susana, Lazo, Pedro A.
Publicado 2011

Proteomics Identification of Nuclear Ran GTPase as an Inhibitor of Human VRK1 and VRK2 (Vaccinia-related Kinase) Activities

por Sanz-García, Marta, López-Sánchez, Inmaculada, Lazo, Pedro A.
Publicado 2008

The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53

por Valbuena, Alberto, Blanco, Sandra, Vega, Francisco M., Lazo, Pedro A.
Publicado 2008

Modulation of Interleukin-1 Transcriptional Response by the Interaction between VRK2 and the JIP1 Scaffold Protein

por Blanco, Sandra, Sanz-García, Marta, Santos, Claudio R., Lazo, Pedro A.
Publicado 2008

VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis

por Moura, David S., Campillo-Marcos, Ignacio, Vázquez-Cedeira, Marta, Lazo, Pedro A.
Publicado 2018

VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes

por Martín-Doncel, Elena, Rojas, Ana M., Cantarero, Lara, Lazo, Pedro A.
Publicado 2019

VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage

por Salzano, Marcella, Sanz-García, Marta, Monsalve, Diana M, Moura, David S, Lazo, Pedro A
Publicado 2015

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2

por Vázquez-Cedeira, Marta, Barcia-Sanjurjo, Iria, Sanz-García, Marta, Barcia, Ramiro, Lazo, Pedro A.
Publicado 2011

VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage

por García-González, Raúl, Morejón-García, Patricia, Campillo-Marcos, Ignacio, Salzano, Marcella, Lazo, Pedro A.
Publicado 2020

Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy

por Campillo-Marcos, Ignacio, Monte-Serrano, Eva, Navarro-Carrasco, Elena, García-González, Raúl, Lazo, Pedro A.
Publicado 2021

VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle

por Cantarero, Lara, Sanz-García, Marta, Vinograd-Byk, Hadar, Renbaum, Paul, Levy-Lahad, Ephrat, Lazo, Pedro A.
Publicado 2015

Dysfunctional Homozygous VRK1-D263G Variant Impairs the Assembly of Cajal Bodies and DNA Damage Response in Hereditary Spastic Paraplegia

por Morejon-Garcia, Patricia, Keren, Boris, Marcos-Alcalde, Iñigo, Gomez-Puertas, Paulino, Mochel, Fanny, Lazo, Pedro. A.
Publicado 2021

The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase

por Monte-Serrano, Eva, Morejón-García, Patricia, Campillo-Marcos, Ignacio, Campos-Díaz, Aurora, Navarro-Carrasco, Elena, Lazo, Pedro A.
Publicado 2023