Genome‐wide analysis of single nucleotide variants allows for robust and accurate assessment of clonal derivation in cell lines used to produce biologics

por Kuhn, Alexandre, Le Fourn, Valérie, Fisch, Igor, Mermod, Nicolas
Publicado 2020

High performance CHO cell line development platform for enhanced production of recombinant proteins including difficult-to-express proteins

por Girod, Pierre-Alain, Le Fourn, Valérie, Calabrese, David, Regamey, Alexandre, Ley, Deborah, Mermod, Nicolas
Publicado 2013

Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

por Berger, Audrey, Le Fourn, Valérie, Masternak, Jacqueline, Regamey, Alexandre, Bodenmann, Iris, Girod, Pierre‐Alain, Mermod, Nicolas
Publicado 2020

Influence of cytoskeleton organization on recombinant protein expression by CHO cells

por Pourcel, Lucille, Buron, Flavien, Arib, Ghislaine, Le Fourn, Valérie, Regamey, Alexandre, Bodenmann, Iris, Girod, Pierre‐Alain, Mermod, Nicolas
Publicado 2020

MAR Elements and Transposons for Improved Transgene Integration and Expression

por Ley, Déborah, Harraghy, Niamh, Le Fourn, Valérie, Bire, Solenne, Girod, Pierre-Alain, Regamey, Alexandre, Rouleux-Bonnin, Florence, Bigot, Yves, Mermod, Nicolas
Publicado 2013

Protein quality control: the who’s who, the where’s and therapeutic escapes

por Roth, Jürgen, Yam, Gary Hin-Fai, Fan, Jingyu, Hirano, Kiyoko, Gaplovska-Kysela, Katarina, Le Fourn, Valerie, Guhl, Bruno, Santimaria, Roger, Torossi, Tania, Ziak, Martin, Zuber, Christian
Publicado 2007

MAR‐Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

por Kostyrko, Kaja, Neuenschwander, Samuel, Junier, Thomas, Regamey, Alexandre, Iseli, Christian, Schmid‐Siegert, Emanuel, Bosshard, Sandra, Majocchi, Stefano, Le Fourn, Valérie, Girod, Pierre‐Alain, Xenarios, Ioannis, Mermod, Nicolas
Publicado 2016

Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies

por Bale, Shridhar, Martiné, Alexandra, Wilson, Richard, Behrens, Anna-Janina, Le Fourn, Valérie, de Val, Natalia, Sharma, Shailendra K., Tran, Karen, Torres, Jonathan L., Girod, Pierre-Alain, Ward, Andrew B., Crispin, Max, Wyatt, Richard T.
Publicado 2018