eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes

por Waldron, Joseph A, Raza, Farheen, Le Quesne, John
Publicado 2018

Repositioning PARP inhibitors for SARS‐CoV‐2 infection(COVID‐19); a new multi‐pronged therapy for acute respiratory distress syndrome?

por Curtin, Nicola, Bányai, Krisztián, Thaventhiran, James, Le Quesne, John, Helyes, Zsuzsanna, Bai, Péter
Publicado 2020

Nanomolar Protein–Protein Interaction Monitoring with a Label-Free Protein-Probe Technique

por Valtonen, Salla, Vuorinen, Emmiliisa, Kariniemi, Taru, Eskonen, Ville, Le Quesne, John, Bushell, Martin, Härmä, Harri, Kopra, Kari
Publicado 2020

Early detection of pre-malignant lesions in a KRAS(G12D)-driven mouse lung cancer model by monitoring circulating free DNA

por Rakhit, Callum P., Trigg, Ricky M., Le Quesne, John, Kelly, Michael, Shaw, Jacqueline A., Pritchard, Catrin, Martins, L. Miguel
Publicado 2019

Decline in Antigenicity of Tumor Markers by Storage Time Using Pathology Sections Cut From Tissue Microarrays

por Blows, Fiona M., Ali, Hamid R., Dawson, Sarah-J., Le Quesne, John, Provenzano, Elena, Caldas, Carlos, Pharoah, Paul D.P.
Publicado 2016

Reduced Protumorigenic Tumor-Associated Macrophages With Statin Use in Premalignant Human Lung Adenocarcinoma

por Al Dujaily, Esraa, Baena, Juvenal, Das, Madhumita, Sereno, Marco, Smith, Claire, Kamata, Tamihiro, Officer, Leah, Pritchard, Catrin, Le Quesne, John
Publicado 2019

Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents

por Fercoq, Frédéric, Remion, Estelle, Vallarino-Lhermitte, Nathaly, Alonso, Joy, Raveendran, Lisy, Nixon, Colin, Le Quesne, John, Carlin, Leo M., Martin, Coralie
Publicado 2020

Statins mediate anti- and pro-tumourigenic functions by remodelling the tumour microenvironment

por Kamata, Tamihiro, Al Dujaily, Esraa, Alhamad, Salwa, So, Tsz Y., Margaritaki, Olga, Giblett, Susan, Pringle, J. Howard, Le Quesne, John, Pritchard, Catrin
Publicado 2022

A Comparison of Immunohistochemical Assays and FISH in Detecting the ALK Translocation in Diagnostic Histological and Cytological Lung Tumor Material

por Le Quesne, John, Maurya, Manisha, Yancheva, Slaveya G., O’Brien, Mary, Popat, Sanjay, Wotherspoon, Andrew C., de Castro, David Gonzalez, Nicholson, Andrew G.
Publicado 2014

IL-4 receptor dependent expansion of lung CD169(+) macrophages in microfilaria-driven inflammation

por Fercoq, Frédéric, Remion, Estelle, Frohberger, Stefan J., Vallarino-Lhermitte, Nathaly, Hoerauf, Achim, Le Quesne, John, Landmann, Frédéric, Hübner, Marc P., Carlin, Leo M., Martin, Coralie
Publicado 2019

Characterisation of microRNA expression in post-natal mouse mammary gland development

por Avril-Sassen, Stefanie, Goldstein, Leonard D, Stingl, John, Blenkiron, Cherie, Le Quesne, John, Spiteri, Inmaculada, Karagavriilidou, Konstantina, Watson, Christine J, Tavaré, Simon, Miska, Eric A, Caldas, Carlos
Publicado 2009

mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity

por Waldron, Joseph A., Tack, David C., Ritchey, Laura E., Gillen, Sarah L., Wilczynska, Ania, Turro, Ernest, Bevilacqua, Philip C., Assmann, Sarah M., Bushell, Martin, Le Quesne, John
Publicado 2019

Inclusion of multiple high‐risk histopathological criteria improves the prediction of adjuvant chemotherapy efficacy in lung adenocarcinoma

por Sereno, Marco, He, Zhangyi, Smith, Claire R, Baena, Juvenal, Das, Madhumita, Hastings, Robert K, Rake, Grace, Fennell, Dean A, Nakas, Apostolos, Moore, David A, Le Quesne, John
Publicado 2021

Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane

por Phatak, Vinaya, von Grabowiecki, Yannick, Janus, Justyna, Officer, Leah, Behan, Caron, Aschauer, Lydia, Pinon, Lucia, Mackay, Hannah, Zanivan, Sara, Norman, Jim C., Kelly, Michael, Le Quesne, John, Muller, Patricia A. J.
Publicado 2021

Genomic instability in mutant p53 cancer cells upon entotic engulfment

por Mackay, Hannah L., Moore, David, Hall, Callum, Birkbak, Nicolai J., Jamal-Hanjani, Mariam, Karim, Saadia A., Phatak, Vinaya M., Piñon, Lucia, Morton, Jennifer P., Swanton, Charles, Le Quesne, John, Muller, Patricia A. J.
Publicado 2018

Publisher Correction: Genomic instability in mutant p53 cancer cells upon entotic engulfment

por Mackay, Hannah L., Moore, David, Hall, Callum, Birkbak, Nicolai J., Jamal-Hanjani, Mariam, Karim, Saadia A., Phatak, Vinaya M., Piñon, Lucia, Morton, Jennifer P., Swanton, Charles, Le Quesne, John, Muller, Patricia A. J.
Publicado 2018

Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma

por Zhang, Hanyun, AbdulJabbar, Khalid, Moore, David A., Akarca, Ayse, Enfield, Katey S.S., Jamal-Hanjani, Mariam, Raza, Shan E. Ahmed, Veeriah, Selvaraju, Salgado, Roberto, McGranahan, Nicholas, Le Quesne, John, Swanton, Charles, Marafioti, Teresa, Yuan, Yinyin
Publicado 2023

eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5′UTR

por Wilczynska, Ania, Gillen, Sarah L., Schmidt, Tobias, Meijer, Hedda A., Jukes-Jones, Rebekah, Langlais, Claudia, Kopra, Kari, Lu, Wei-Ting, Godfrey, Jack D., Hawley, Benjamin R., Hodge, Kelly, Zanivan, Sara, Cain, Kelvin, Le Quesne, John, Bushell, Martin
Publicado 2019

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression

por Amelio, Ivano, Mancini, Mara, Petrova, Varvara, Cairns, Rob A., Vikhreva, Polina, Nicolai, Sara, Marini, Alberto, Antonov, Alexey A., Le Quesne, John, Baena Acevedo, Juvenal D., Dudek, Kate, Sozzi, Gabriella, Pastorino, Ugo, Knight, Richard A., Mak, Tak W., Melino, Gerry
Publicado 2018

eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation

por Schmidt, Tobias, Dabrowska, Adrianna, Waldron, Joseph A, Hodge, Kelly, Koulouras, Grigorios, Gabrielsen, Mads, Munro, June, Tack, David C, Harris, Gemma, McGhee, Ewan, Scott, David, Carlin, Leo M, Huang, Danny, Le Quesne, John, Zanivan, Sara, Wilczynska, Ania, Bushell, Martin
Publicado 2023