Novel therapeutic target against Alzheimer

por LeBlanc, Andrea C.
Publicado 2017

Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element

por Déry, Marc-André, LeBlanc, Andréa C.
Publicado 2017

Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits

por Noël, Anastasia, Foveau, Bénédicte, LeBlanc, Andréa C.
Publicado 2021

Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice

por Flores, Joseph, Fillion, Marie-Lyne, LeBlanc, Andréa C.
Publicado 2022

Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine

por Pakavathkumar, Prateep, Sharma, Gyanesh, Kaushal, Vikas, Foveau, Bénédicte, LeBlanc, Andrea C.
Publicado 2015

Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

por Flores, Joseph, Noël, Anastasia, Foveau, Bénédicte, Beauchet, Olivier, LeBlanc, Andréa C.
Publicado 2020

Publisher Correction: Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

por Flores, Joseph, Noël, Anastasia, Foveau, Bénédicte, Beauchet, Olivier, LeBlanc, Andréa C.
Publicado 2021

Expression and Activation of Caspase-6 in Human Fetal and Adult Tissues

por Godefroy, Nelly, Foveau, Bénédicte, Albrecht, Steffen, Goodyer, Cynthia G., LeBlanc, Andréa C.
Publicado 2013

Inflammation-Induced Tumorigenesis in Mouse Colon Is Caspase-6 Independent

por Foveau, Bénédicte, Van Der Kraak, Lauren, Beauchemin, Nicole, Albrecht, Steffen, LeBlanc, Andréa C.
Publicado 2014

Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment

por Foveau, Benedicte, Albrecht, Steffen, Bennett, David A., Correa, José A., LeBlanc, Andrea C.
Publicado 2016

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

por Flores, Joseph, Noël, Anastasia, Foveau, Bénédicte, Lynham, Jeffrey, Lecrux, Clotilde, LeBlanc, Andréa C.
Publicado 2018

Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice

por Zhou, Libin, Flores, Joseph, Noël, Anastasia, Beauchet, Olivier, Sjöström, P. Jesper, LeBlanc, Andrea C.
Publicado 2019

Loss of Anti-Bax Function in Gerstmann-Sträussler-Scheinker Syndrome-Associated Prion Protein Mutants

por Jodoin, Julie, Misiewicz, Micheal, Makhijani, Priya, Giannopoulos, Paresa N., Hammond, Jennifer, Goodyer, Cynthia G., LeBlanc, Andréa C.
Publicado 2009

Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury

por Sokolowski, Jennifer D, Gamage, Kanchana K, Heffron, Daniel S, LeBlanc, Andrea C, Deppmann, Christopher D, Mandell, James W
Publicado 2014

Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

por Pakavathkumar, Prateep, Noël, Anastasia, Lecrux, Clotilde, Tubeleviciute-Aydin, Agne, Hamel, Edith, Ahlfors, Jan-Eric, LeBlanc, Andrea C.
Publicado 2017

Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer

por Déry, Marc-André, Jodoin, Julie, Ursini-Siegel, Josie, Aleynikova, Olga, Ferrario, Cristiano, Hassan, Saima, Basik, Mark, LeBlanc, Andréa C
Publicado 2013

Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity

por Tubeleviciute-Aydin, Agne, Zhou, Libin, Sharma, Gyanesh, Soni, Ishankumar V., Savinov, Sergey N., Hardy, Jeanne A., LeBlanc, Andrea C.
Publicado 2018

The Consortium for the early identification of Alzheimer's disease–Quebec (CIMA-Q)

por Belleville, Sylvie, LeBlanc, Andréa C., Kergoat, Marie-Jeanne, Calon, Frédéric, Gaudreau, Pierrette, Hébert, Sébastien S., Hudon, Carol, Leclerc, Nicole, Mechawar, Naguib, Duchesne, Simon, Gauthier, Serge
Publicado 2019

Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration

por Zhou, Libin, Nho, Kwangsik, Haddad, Maria G., Cherepacha, Nicole, Tubeleviciute-Aydin, Agne, Tsai, Andy P., Saykin, Andrew J., Jesper Sjöström, P., LeBlanc, Andrea C.
Publicado 2021

Author Correction: Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration

por Zhou, Libin, Nho, Kwangsik, Haddad, Maria G., Cherepacha, Nicole, Tubeleviciute-Aydin, Agne, Tsai, Andy P., Saykin, Andrew J., Sjöström, P. Jesper, LeBlanc, Andrea C.
Publicado 2021