Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses

por Heinonen, Tytti, Ciarlo, Eleonora, Le Roy, Didier, Roger, Thierry
Publicado 2019

Mouse Model of Respiratory Tract Infection Induced by Waddlia chondrophila

por Pilloux, Ludovic, LeRoy, Didier, Brunel, Christophe, Roger, Thierry, Greub, Gilbert
Publicado 2016

Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia

por Heinonen, Tytti, Ciarlo, Eleonora, Rigoni, Ersilia, Regina, Jean, Le Roy, Didier, Roger, Thierry
Publicado 2019

Differential activity of novel gametocytocidal compounds: drug mode-of-action and ex vivo efficacy

por Birkholtz, Lyn-Marie, LeRoy, Didier, Reader, Janette, Botha, Mariette, Mancama, Dalu, Coetzer, Theresa L
Publicado 2014

Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo

por Ciarlo, Eleonora, Heinonen, Tytti, Herderschee, Jacobus, Fenwick, Craig, Mombelli, Matteo, Le Roy, Didier, Roger, Thierry
Publicado 2016

Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections

por Heinonen, Tytti, Ciarlo, Eleonora, Théroude, Charlotte, Pelekanou, Aimilia, Herderschee, Jacobus, Le Roy, Didier, Roger, Thierry
Publicado 2018

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

por Ciarlo, Eleonora, Heinonen, Tytti, Lugrin, Jérôme, Acha-Orbea, Hans, Le Roy, Didier, Auwerx, Johan, Roger, Thierry
Publicado 2017

Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections

por Ciarlo, Eleonora, Heinonen, Tytti, Théroude, Charlotte, Asgari, Fatemeh, Le Roy, Didier, Netea, Mihai G, Roger, Thierry
Publicado 2019

The Anticancer Peptide TAT-RasGAP(317−326) Exerts Broad Antimicrobial Activity

por Heulot, Mathieu, Jacquier, Nicolas, Aeby, Sébastien, Le Roy, Didier, Roger, Thierry, Trofimenko, Evgeniya, Barras, David, Greub, Gilbert, Widmann, Christian
Publicado 2017

Fully human anti-macrophage migration inhibitory factor antibodies as potential therapeutics for sepsis and septic shock

por Kerschbaumer, Randolf, Rieger, Manfred, Antoine, Gerhard, Völkel, Dirk, Le Roy, Didier, Roger, Thierry, Savidis-Dacho, Helga, Calandra, Thierry, Scheiflinger, Fritz
Publicado 2008

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

por Ives, Annette, Nomura, Johji, Martinon, Fabio, Roger, Thierry, LeRoy, Didier, Miner, Jeffrey N., Simon, Gregoire, Busso, Nathalie, So, Alexander
Publicado 2015

Trained Immunity Confers Prolonged Protection From Listeriosis

por Théroude, Charlotte, Reverte, Marta, Heinonen, Tytti, Ciarlo, Eleonora, Schrijver, Irene T., Antonakos, Nikolaos, Maillard, Nicolas, Pralong, Florian, Le Roy, Didier, Roger, Thierry
Publicado 2021

Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination

por Choteau, Laura, Vancraeyneste, Hélène, Le Roy, Didier, Dubuquoy, Laurent, Romani, Luiginia, Jouault, Thierry, Poulain, Daniel, Sendid, Boualem, Calandra, Thierry, Roger, Thierry, Jawhara, Samir
Publicado 2017

COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions

por Schrijver, Irene T., Théroude, Charlotte, Antonakos, Nikolaos, Regina, Jean, Le Roy, Didier, Bart, Pierre‐Alexandre, Chiche, Jean‐Daniel, Perreau, Matthieu, Pantaleo, Giuseppe, Calandra, Thierry, Roger, Thierry
Publicado 2022

Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection

por Ciarlo, Eleonora, Heinonen, Tytti, Théroude, Charlotte, Herderschee, Jacobus, Mombelli, Matteo, Lugrin, Jérôme, Pfefferlé, Marc, Tyrrell, Beatrice, Lensch, Sarah, Acha-Orbea, Hans, Le Roy, Didier, Auwerx, Johan, Roger, Thierry
Publicado 2017

Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome

por Delaloye, Julie, Roger, Thierry, Steiner-Tardivel, Quynh-Giao, Le Roy, Didier, Knaup Reymond, Marlies, Akira, Shizuo, Petrilli, Virginie, Gomez, Carmen E., Perdiguero, Beatriz, Tschopp, Jürg, Pantaleo, Giuseppe, Esteban, Mariano, Calandra, Thierry
Publicado 2009

Expression and Function of Macrophage Migration Inhibitory Factor (MIF) in Melioidosis

por Wiersinga, W. Joost, Calandra, Thierry, Kager, Liesbeth M., van der Windt, Gerritje J. W., Roger, Thierry, le Roy, Didier, Florquin, Sandrine, Peacock, Sharon J., Sweep, Fred C. G. J., van der Poll, Tom
Publicado 2010

Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

por Demarco, Benjamin, Grayczyk, James P., Bjanes, Elisabet, Le Roy, Didier, Tonnus, Wulf, Assenmacher, Charles-Antoine, Radaelli, Enrico, Fettrelet, Timothée, Mack, Vanessa, Linkermann, Andreas, Roger, Thierry, Brodsky, Igor E., Chen, Kaiwen W., Broz, Petr
Publicado 2020

Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity

por Pfefferlé, Marc, Dubach, Irina L, Buzzi, Raphael M, Dürst, Elena, Schulthess-Lutz, Nadja, Baselgia, Livio, Hansen, Kerstin, Imhof, Larissa, Koernig, Sandra, Le Roy, Didier, Roger, Thierry, Humar, Rok, Schaer, Dominik J, Vallelian, Florence
Publicado 2023