Anionic Oligothiophenes Compete for Binding of X‐34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain‐Derived Aβ

por Bäck, Marcus, Appelqvist, Hanna, LeVine, Harry, Nilsson, K. Peter R.
Publicado 2016

Similar promotion of Aβ(1-42 )fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms

por Sweeney, David, Martins, Ralph, LeVine, Harry, Smith, Jonathan D, Gandy, Sam
Publicado 2004

Combining Chalcones with Donepezil to Inhibit Both Cholinesterases and Aβ Fibril Assembly

por Thamban Chandrika, Nishad, Fosso, Marina Y., Tsodikov, Oleg V., LeVine, Harry, Garneau-Tsodikova, Sylvie
Publicado 2019

Alzheimer’s protection effect of A673T mutation may be driven by lower Aβ oligomer binding affinity

por Limegrover, Colleen S., LeVine, Harry, Izzo, Nicholas J., Yurko, Raymond, Mozzoni, Kelsie, Rehak, Courtney, Sadlek, Kelsey, Safferstein, Hank, Catalano, Susan M.
Publicado 2020

RNA Oxidation Adducts 8-OHG and 8-OHA Change with Aβ(42) Levels in Late-Stage Alzheimer's Disease

por Weidner, Adam M., Bradley, Melissa A., Beckett, Tina L., Niedowicz, Dana M., Dowling, Amy L. S., Matveev, Sergey V., LeVine, Harry, Lovell, Mark A., Murphy, M. Paul
Publicado 2011

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

por Izzo, Nicholas J., Xu, Jinbin, Zeng, Chenbo, Kirk, Molly J., Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Cruchaga, Carlos, Goate, Alison, Cahill, Michael A., Arancio, Ottavio, Mach, Robert H., Craven, Rolf, Head, Elizabeth, LeVine, Harry, Spires-Jones, Tara L., Catalano, Susan M.
Publicado 2014

A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer’s disease using an indwelling CSF catheter

por LaBarbera, Kelsie M., Sheline, Yvette I., Izzo, Nicholas J., Yuede, Carla M., Waybright, Lora, Yurko, Raymond, Edwards, Hannah M., Gardiner, Woodrow D., Blennow, Kaj, Zetterberg, Henrik, Börjesson-Hanson, Anne, Morgan, Roger, Davis, Charles S., Guttendorf, Robert J., Schneider, Lon S., DeKosky, Steven, LeVine, Harry, Grundman, Michael, Caggiano, Anthony O., Cirrito, John R., Catalano, Susan M., Hamby, Mary E.
Publicado 2023

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive De...

por Izzo, Nicholas J., Staniszewski, Agnes, To, Lillian, Fa, Mauro, Teich, Andrew F., Saeed, Faisal, Wostein, Harrison, Walko, Thomas, Vaswani, Anisha, Wardius, Meghan, Syed, Zanobia, Ravenscroft, Jessica, Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Finn, Patricia, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Miller, Miles, Johanson, Conrad, Stopa, Edward, Windisch, Manfred, Hutter-Paier, Birgit, Shamloo, Mehrdad, Arancio, Ottavio, LeVine, Harry, Catalano, Susan M.
Publicado 2014

Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification

por Izzo, Nicholas J., Yuede, Carla M., LaBarbera, Kelsie M., Limegrover, Colleen S., Rehak, Courtney, Yurko, Raymond, Waybright, Lora, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Hamby, Mary E., Williams, Claire, Sadlek, Kelsey, Edwards, Hannah M., Davis, Charles S., Grundman, Michael, Schneider, Lon S., DeKosky, Steven T., Chelsky, Daniel, Pike, Ian, Henstridge, Christopher, Blennow, Kaj, Zetterberg, Henrik, LeVine, Harry, Spires‐Jones, Tara L., Cirrito, John R., Catalano, Susan M.
Publicado 2021