Transcription factors in eukaryotic cells can functionally regulate gene expression by acting in oligomeric assemblies formed from an intrinsically disordered protein phase transit...

por Leake, Mark C.
Publicado 2018

Experimental approaches for addressing fundamental biological questions in living, functioning cells with single molecule precision

por Lenn, Tchern, Leake, Mark C.
Publicado 2012

Single-molecule fluorescence microscopy review: shedding new light on old problems

por Shashkova, Sviatlana, Leake, Mark C.
Publicado 2017

Functioning Nanomachines Seen in Real-Time in Living Bacteria Using Single-Molecule and Super-Resolution Fluorescence Imaging

por Chiu, Sheng-Wen, Leake, Mark C.
Publicado 2011

Correlative single-molecule fluorescence barcoding of gene regulation in Saccharomyces cerevisiae

por Shashkova, Sviatlana, Nyström, Thomas, Leake, Mark C., Wollman, Adam J.M.
Publicado 2021

Structural interplay between DNA-shape protein recognition and supercoiling: The case of IHF

por Watson, George D., Chan, Elliot W., Leake, Mark C., Noy, Agnes
Publicado 2022

From Animaculum to single molecules: 300 years of the light microscope

por Wollman, Adam J. M., Nudd, Richard, Hedlund, Erik G., Leake, Mark C.
Publicado 2015

Towards mapping the 3D genome through high speed single-molecule tracking of functional transcription factors in single living cells

por Wollman, Adam J.M., Hedlund, Erik G., Shashkova, Sviatlana, Leake, Mark C.
Publicado 2020

PySTACHIO: Python Single-molecule TrAcking stoiCHiometry Intensity and simulatiOn, a flexible, extensible, beginner-friendly and optimized program for analysis of single-molecule m...

por Shepherd, Jack W., Higgins, Ed J., Wollman, Adam J.M., Leake, Mark C.
Publicado 2021

Single-molecule and super-resolved imaging deciphers membrane behavior of onco-immunogenic CCR5

por Hunter, Patrick, Payne-Dwyer, Alex L., Shaw, Michael, Signoret, Nathalie, Leake, Mark C.
Publicado 2022

Single-Organelle Quantification Reveals Stoichiometric and Structural Variability of Carboxysomes Dependent on the Environment

por Sun, Yaqi, Wollman, Adam J. M., Huang, Fang, Leake, Mark C., Liu, Lu-Ning
Publicado 2019

Crowding-induced morphological changes in synthetic lipid vesicles determined using smFRET

por Quinn, Steven D., Dresser, Lara, Graham, Sarah, Conteduca, Donato, Shepherd, Jack, Leake, Mark C.
Publicado 2022

Transcription factor clusters regulate genes in eukaryotic cells

por Wollman, Adam JM, Shashkova, Sviatlana, Hedlund, Erik G, Friemann, Rosmarie, Hohmann, Stefan, Leake, Mark C
Publicado 2017

Correction: Transcription factor clusters regulate genes in eukaryotic cells

por Wollman, Adam JM, Shashkova, Sviatlana, Hedlund, Erik G, Friemann, Rosmarie, Hohmann, Stefan, Leake, Mark C
Publicado 2019

The emergence of sequence-dependent structural motifs in stretched, torsionally constrained DNA

por Shepherd, Jack W, Greenall, Robert J, Probert, Matt I J, Noy, Agnes, Leake, Mark C
Publicado 2020

Investigating molecular crowding during cell division in budding yeast with FRET

por Lecinski, Sarah, Shepherd, Jack W, Frame, Lewis, Hayton, Imogen, MacDonald, Chris, Leake, Mark C
Publicado 2021

RecA and RecB: probing complexes of DNA repair proteins with mitomycin C in live Escherichia coli with single-molecule sensitivity

por Payne-Dwyer, Alex L., Syeda, Aisha H., Shepherd, Jack W., Frame, Lewis, Leake, Mark C.
Publicado 2022

Independent mobility of proteins and lipids in the plasma membrane of Escherichia coli

por Nenninger, Anja, Mastroianni, Giulia, Robson, Alexander, Lenn, Tchern, Xue, Quan, Leake, Mark C, Mullineaux, Conrad W
Publicado 2014

Single-molecule optical microscopy of protein dynamics and computational analysis of images to determine cell structure development in differentiating Bacillus subtilis

por Wollman, Adam J.M., Muchová, Katarína, Chromiková, Zuzana, Wilkinson, Anthony J., Barák, Imrich, Leake, Mark C.
Publicado 2020

Frequent exchange of the DNA polymerase during bacterial chromosome replication

por Beattie, Thomas R, Kapadia, Nitin, Nicolas, Emilien, Uphoff, Stephan, Wollman, Adam JM, Leake, Mark C, Reyes-Lamothe, Rodrigo
Publicado 2017