Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist

por Leaker, Brian R, Barnes, Peter J, O’Connor, Brian
Publicado 2013

Using magnetic resonance imaging to quantify the inflammatory response following allergen challenge in allergic rhinitis

por Leaker, Brian R., Scadding, Glenis, Jones, C. Richard, Barnes, Peter J.
Publicado 2015

Conditional neuromodulation of neurogenic detrusor overactivity using transrectal stimulation in patients with spinal cord injury: A proof of principle study

por Knight, Sarah Louise, Edirisinghe, Nuwani, Leaker, Brian, Susser, Judith, Craggs, Michael Duncan
Publicado 2017

Efficacy and safety of nebulized glycopyrrolate for administration using a high efficiency nebulizer in patients with chronic obstructive pulmonary disease

por Leaker, Brian R, Barnes, Peter J, Jones, C Richard, Tutuncu, Ahmet, Singh, Dave
Publicado 2015

The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma

por Leaker, Brian R, Singh, Dave, Ali, Ferhana Y, Barnes, Peter J, O’Connor, Brian
Publicado 2014

Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study

por Leaker, Brian R., Singh, Dave, Lindgren, Sam, Almqvist, Gun, Eriksson, Leif, Young, Barbara, O’Connor, Brian
Publicado 2019

Rapid effects of extrafine beclomethasone dipropionate/formoterol fixed combination inhaler on airway inflammation and bronchoconstriction in asthma: a randomised controlled trial

por O'Connor, Brian J, Collarini, Sara, Poli, Gianluigi, Brindicci, Caterina, Spinola, Monica, Acerbi, Daniela, Barnes, Peter J, Leaker, Brian
Publicado 2011

Evaluation of systemic absorption and bronchodilator effect of glycopyrronium bromide delivered by nebulizer or a dry powder inhaler in subjects with chronic obstructive pulmonary...

por Leaker, Brian R., Singh, Dave, Nicholson, Grant C., Hezelova, Blanka, Goodin, Thomas, Ozol-Godfrey, Ayca, Galluppi, Gerald, Barnes, Peter J.
Publicado 2019

Comparison of the effect of beclometasone/formoterol in asthma patients after methacholine‐induced bronchoconstriction: A noninferiority study using metered dose vs. dry powder inh...

por Singh, Dave, van den Berg, Frans, Leaker, Brian, Corradi, Massimo, Jabbal, Sunny, Collarini, Sara, Mongelli, Valentina, Santoro, Luigi, Piccinno, Annalisa, Biondaro, Sonia, Lipworth, Brian
Publicado 2019

Effect of the inhaled PDE4 inhibitor CHF6001 on biomarkers of inflammation in COPD

por Singh, Dave, Beeh, Kai Michael, Colgan, Brendan, Kornmann, Oliver, Leaker, Brian, Watz, Henrik, Lucci, Germano, Geraci, Silvia, Emirova, Aida, Govoni, Mirco, Nandeuil, Marie Anna
Publicado 2019

COPD sputum eosinophils: relationship to blood eosinophils and the effect of inhaled PDE4 inhibition

por Singh, Dave, Watz, Henrik, Beeh, Kai Michael, Kornmann, Oliver, Leaker, Brian, Colgan, Brendan, Lucci, Germano, Emirova, Aida, Nandeuil, Marie Anna, Santoro, Debora, Balzano, Deborah, Govoni, Mirco
Publicado 2020

COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type‐2 and PDE4 gene expression in sputum

por Singh, Dave, Bassi, Michele, Balzano, Deborah, Lucci, Germano, Emirova, Aida, Anna Nandeuil, Marie, Jellema, Gera, Afolabi, Ebenezer K., Leaker, Brian, Kornmann, Oliver, Michael Beeh, Kai, Watz, Henrik, Govoni, Mirco
Publicado 2020

Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis

por Govoni, Mirco, Bassi, Michele, Vezzoli, Stefano, Lucci, Germano, Emirova, Aida, Nandeuil, Marie Anna, Petruzzelli, Stefano, Jellema, Gera L., Afolabi, Ebenezer K., Colgan, Brendan, Leaker, Brian, Kornmann, Oliver, Beeh, Kai Michael, Watz, Henrik, Singh, Dave
Publicado 2020