IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia

por Xu, Aizhang, Bhanumathy, Kalpana Kalyanasundaram, Wu, Jie, Ye, Zhenmin, Freywald, Andrew, Leary, Scot C., Li, Rongxiu, Xiang, Jim
Publicado 2016

The Energy Sensor AMPKα1 Is Critical in Rapamycin-Inhibition of mTORC1-S6K-Induced T-cell Memory

por Ara, Anjuman, Xu, Aizhang, Ahmed, Khawaja Ashfaque, Leary, Scot C., Islam, Md. Fahmid, Wu, Zhaojia, Chibbar, Rajni, Xiang, Jim
Publicado 2021

The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation

por El Zawily, Amr M., Toosi, Behzad M., Freywald, Tanya, Indukuri, Vijaya V., Vizeacoumar, Franco J., Leary, Scot C., Freywald, Andrew
Publicado 2016

The Critical Role of AMPKα1 in Regulating Autophagy and Mitochondrial Respiration in IL-15-Stimulated mTORC1(Weak) Signal-Induced T Cell Memory: An Interplay between Yin (AMPKα1) a...

por Ara, Anjuman, Wu, Zhaojia, Xu, Aizhang, Ahmed, Khawaja Ashfaque, Leary, Scot C., Islam, Md. Fahmid, Chibbar, Rajni, Wu, Yue, Xiang, Jim
Publicado 2022

Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes

por Zhu, Xinyu, Boulet, Aren, Buckley, Katherine M, Phillips, Casey B, Gammon, Micah G, Oldfather, Laura E, Moore, Stanley A, Leary, Scot C, Cobine, Paul A
Publicado 2021

COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux

por Leary, Scot C., Cobine, Paul A., Nishimura, Tamiko, Verdijk, Robert M., de Krijger, Ronald, de Coo, René, Tarnopolsky, Mark A., Winge, Dennis R., Shoubridge, Eric A.
Publicado 2013

The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart

por Baker, Zakery N, Jett, Kimberly, Boulet, Aren, Hossain, Amzad, Cobine, Paul A, Kim, Byung-Eun, El Zawily, Amr M, Lee, Ling, Tibbits, Glen F, Petris, Michael J, Leary, Scot C
Publicado 2017

Elesclomol restores mitochondrial function in genetic models of copper deficiency

por Soma, Shivatheja, Latimer, Andrew J., Chun, Haarin, Vicary, Alison C., Timbalia, Shrishiv A., Boulet, Aren, Rahn, Jennifer J., Chan, Sherine S. L., Leary, Scot C., Kim, Byung-Eun, Gitlin, Jonathan D., Gohil, Vishal M.
Publicado 2018

COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase

por Soma, Shivatheja, Morgada, Marcos N., Naik, Mandar T., Boulet, Aren, Roesler, Anna A., Dziuba, Nathaniel, Ghosh, Alok, Yu, Qinhong, Lindahl, Paul A., Ames, James B., Leary, Scot C., Vila, Alejandro J., Gohil, Vishal M.
Publicado 2019

The Aβ(1–38) peptide is a negative regulator of the Aβ(1–42) peptide implicated in Alzheimer disease progression

por Quartey, Maa O., Nyarko, Jennifer N. K., Maley, Jason M., Barnes, Jocelyn R., Bolanos, Maria A. C., Heistad, Ryan M., Knudsen, Kaeli J., Pennington, Paul R., Buttigieg, Josef, De Carvalho, Carlos E., Leary, Scot C., Parsons, Matthew P., Mousseau, Darrell D.
Publicado 2021

Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models

por Jett, Kimberly A., Baker, Zakery N., Hossain, Amzad, Boulet, Aren, Cobine, Paul A., Ghosh, Sagnika, Ng, Philip, Yilmaz, Orhan, Barreto, Kris, DeCoteau, John, Mochoruk, Karen, Ioannou, George N., Savard, Christopher, Yuan, Sai, Abdalla, Osama H.M.H., Lowden, Christopher, Kim, Byung-Eun, Cheng, Hai-Ying Mary, Battersby, Brendan J., Gohil, Vishal M., Leary, Scot C.
Publicado 2023