MutL binds to 3′ resected DNA ends and blocks DNA polymerase access

por Borsellini, Alessandro, Lebbink, Joyce H G, Lamers, Meindert H
Publicado 2022

Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants

por Laffeber, Charlie, de Koning, Kelly, Kanaar, Roland, Lebbink, Joyce H.G.
Publicado 2021

Magnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutS

por Lebbink, Joyce H. G., Fish, Alexander, Reumer, Annet, Natrajan, Ganesh, Winterwerp, Herrie H. K., Sixma, Titia K.
Publicado 2010

Torsional regulation of hRPA-induced unwinding of double-stranded DNA

por De Vlaminck, Iwijn, Vidic, Iztok, van Loenhout, Marijn T. J., Kanaar, Roland, Lebbink, Joyce H. G., Dekker, Cees
Publicado 2010

C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties

por Inagawa, Takabumi, Wennink, Thomas, Lebbink, Joyce H. G., Keijzers, Guido, Florea, Bogdan I., Verkaik, Nicole S., van Gent, Dik C.
Publicado 2020

Architectural plasticity of human BRCA2–RAD51 complexes in DNA break repair

por Sánchez, Humberto, Paul, Maarten W., Grosbart, Małgorzata, van Rossum-Fikkert, Sarah E., Lebbink, Joyce H. G., Kanaar, Roland, Houtsmuller, Adriaan B., Wyman, Claire
Publicado 2017

ARP/wARP and molecular replacement: the next generation

por Cohen, Serge X., Ben Jelloul, Marouane, Long, Fei, Vagin, Alexei, Knipscheer, Puck, Lebbink, Joyce, Sixma, Titia K., Lamzin, Victor S., Murshudov, Garib N., Perrakis, Anastassis
Publicado 2008

Semi-quantitative proteomics of mammalian cells upon short-term exposure to non-ionizing electromagnetic fields

por Kuzniar, Arnold, Laffeber, Charlie, Eppink, Berina, Bezstarosti, Karel, Dekkers, Dick, Woelders, Henri, Zwamborn, A. Peter M., Demmers, Jeroen, Lebbink, Joyce H. G., Kanaar, Roland
Publicado 2017

APEX1 Nuclease and Redox Functions are Both Essential for Adult Mouse Hematopoietic Stem and Progenitor Cells

por Zaunz, Samantha, De Smedt, Jonathan, Lauwereins, Lukas, Cleuren, Lana, Laffeber, Charlie, Bajaj, Manmohan, Lebbink, Joyce H. G., Marteijn, Jurgen A., De Keersmaecker, Kim, Verfaillie, Catherine
Publicado 2023

Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation

por Groothuizen, Flora S., Fish, Alexander, Petoukhov, Maxim V., Reumer, Annet, Manelyte, Laura, Winterwerp, Herrie H. K., Marinus, Martin G., Lebbink, Joyce H. G., Svergun, Dmitri I., Friedhoff, Peter, Sixma, Titia K.
Publicado 2013

Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair

por Hermans, Nicolaas, Laffeber, Charlie, Cristovão, Michele, Artola-Borán, Mariela, Mardenborough, Yannicka, Ikpa, Pauline, Jaddoe, Aruna, Winterwerp, Herrie H.K., Wyman, Claire, Jiricny, Josef, Kanaar, Roland, Friedhoff, Peter, Lebbink, Joyce H.G.
Publicado 2016

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

por Groothuizen, Flora S, Winkler, Ines, Cristóvão, Michele, Fish, Alexander, Winterwerp, Herrie HK, Reumer, Annet, Marx, Andreas D, Hermans, Nicolaas, Nicholls, Robert A, Murshudov, Garib N, Lebbink, Joyce HG, Friedhoff, Peter, Sixma, Titia K
Publicado 2015

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair

por Mardenborough, Yannicka S N, Nitsenko, Katerina, Laffeber, Charlie, Duboc, Camille, Sahin, Enes, Quessada-Vial, Audrey, Winterwerp, Herrie H K, Sixma, Titia K, Kanaar, Roland, Friedhoff, Peter, Strick, Terence R, Lebbink, Joyce H G
Publicado 2019

Mechanistic and evolutionary insights into a type V-M CRISPR–Cas effector enzyme

por Omura, Satoshi N., Nakagawa, Ryoya, Südfeld, Christian, Villegas Warren, Ricardo, Wu, Wen Y., Hirano, Hisato, Laffeber, Charlie, Kusakizako, Tsukasa, Kise, Yoshiaki, Lebbink, Joyce H. G., Itoh, Yuzuru, van der Oost, John, Nureki, Osamu
Publicado 2023

Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS

por Monti, Maria Chiara, Cohen, Serge X., Fish, Alexander, Winterwerp, Herrie H. K., Barendregt, Arjan, Friedhoff, Peter, Perrakis, Anastassis, Heck, Albert J. R., Sixma, Titia K., van den Heuvel, Robert H. H., Lebbink, Joyce H. G.
Publicado 2011

Guide-free Cas9 from pathogenic Campylobacter jejuni bacteria causes severe damage to DNA

por Saha, Chinmoy, Mohanraju, Prarthana, Stubbs, Andrew, Dugar, Gaurav, Hoogstrate, Youri, Kremers, Gert-Jan, van Cappellen, Wiggert A., Horst-Kreft, Deborah, Laffeber, Charlie, Lebbink, Joyce H.G., Bruens, Serena, Gaskin, Duncan, Beerens, Dior, Klunder, Maarten, Joosten, Rob, Demmers, Jeroen A. A., van Gent, Dik, Mouton, Johan W., van der Spek, Peter J., van der Oost, John, van Baarlen, Peter, Louwen, Rogier
Publicado 2020

Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency

por Stoszko, Mateusz, Al-Hatmi, Abdullah M. S., Skriba, Anton, Roling, Michael, Ne, Enrico, Crespo, Raquel, Mueller, Yvonne M., Najafzadeh, Mohammad Javad, Kang, Joyce, Ptackova, Renata, LeMasters, Elizabeth, Biswas, Pritha, Bertoldi, Alessia, Kan, Tsung Wai, de Crignis, Elisa, Sulc, Miroslav, Lebbink, Joyce H.G., Rokx, Casper, Verbon, Annelies, van Ijcken, Wilfred, Katsikis, Peter D., Palstra, Robert-Jan, Havlicek, Vladimir, de Hoog, Sybren, Mahmoudi, Tokameh
Publicado 2020

Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder

por Kaiser, Fabian M.P., Gruenbacher, Sarah, Oyaga, Maria Roa, Nio, Enzo, Jaritz, Markus, Sun, Qiong, van der Zwaag, Wietske, Kreidl, Emanuel, Zopf, Lydia M., Dalm, Virgil A.S.H., Pel, Johan, Gaiser, Carolin, van der Vliet, Rick, Wahl, Lucas, Rietman, André, Hill, Louisa, Leca, Ines, Driessen, Gertjan, Laffeber, Charlie, Brooks, Alice, Katsikis, Peter D., Lebbink, Joyce H.G., Tachibana, Kikuë, van der Burg, Mirjam, De Zeeuw, Chris I., Badura, Aleksandra, Busslinger, Meinrad
Publicado 2022

Correction: Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder

por Kaiser, Fabian M.P., Gruenbacher, Sarah, Oyaga, Maria Roa, Nio, Enzo, Jaritz, Markus, Sun, Qiong, van der Zwaag, Wietske, Kreidl, Emanuel, Zopf, Lydia M., Dalm, Virgil A.S.H., Pel, Johan, Gaiser, Carolin, van der Vliet, Rick, Wahl, Lucas, Rietman, André, Hill, Louisa, Leca, Ines, Driessen, Gertjan, Laffeber, Charlie, Brooks, Alice, Katsikis, Peter D., Lebbink, Joyce H.G., Tachibana, Kikuë, van der Burg, Mirjam, De Zeeuw, Chris I., Badura, Aleksandra, Busslinger, Meinrad
Publicado 2022