Increased Cellular Senescence and Vascular Rarefaction Exacerbate the Progression of Kidney Fibrosis in Aged Mice Following Transient Ischemic Injury

por Clements, Meghan E., Chaber, Christopher J., Ledbetter, Steven R., Zuk, Anna
Publicado 2013

CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD

por Bukanov, Nikolay O., Moreno, Sarah E., Natoli, Thomas A., Rogers, Kelly A., Smith, Laurie A., Ledbetter, Steven R., Oumata, Nassima, Galons, Hervé, Meijer, Laurent, Ibraghimov-Beskrovnaya, Oxana
Publicado 2012

Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD

por Rogers, Kelly A., Moreno, Sarah E., Smith, Laurie A., Husson, Hervé, Bukanov, Nikolay O., Ledbetter, Steven R., Budman, Yeva, Lu, Yuefeng, Wang, Bing, Ibraghimov‐Beskrovnaya, Oxana, Natoli, Thomas A.
Publicado 2016

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease

por Natoli, Thomas A., Husson, Hervé, Rogers, Kelly A., Smith, Laurie A., Wang, Bing, Budman, Yeva, Bukanov, Nikolay O., Ledbetter, Steven R., Klinger, Katherine W., Leonard, John P., Ibraghimov-Beskrovnaya, Oxana
Publicado 2012

Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar M...

por Pozdzik, Agnieszka A., Giordano, Laetitia, Li, Gang, Antoine, Marie-Hélène, Quellard, Nathalie, Godet, Julie, De Prez, Eric, Husson, Cécile, Declèves, Anne-Emilie, Arlt, Volker M., Goujon, Jean-Michel, Brochériou-Spelle, Isabelle, Ledbetter, Steven R., Caron, Nathalie, Nortier, Joëlle L.
Publicado 2016

A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis

por Trachtman, Howard, Fervenza, Fernando C, Gipson, Debbie S, Heering, Peter, Jayne, David R W, Peters, Harm, Rota, Stefano, Remuzzi, Giuseppe, Rump, L Christian, Sellin, Lorenz K, Heaton, Jeremy P W, Streisand, James B, Hard, Marjie L, Ledbetter, Steven R, Vincenti, Flavio
Publicado 2011

Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis

por Husson, Hervé, Moreno, Sarah, Smith, Laurie A., Smith, Mandy M., Russo, Ryan J., Pitstick, Rose, Sergeev, Mikhail, Ledbetter, Steven R., Bukanov, Nikolay O., Lane, Monica, Zhang, Kate, Billot, Katy, Carlson, George, Shah, Jagesh, Meijer, Laurent, Beier, David R., Ibraghimov-Beskrovnaya, Oxana
Publicado 2016