Protein Misfolding and ER Stress in Huntington's Disease

por Shacham, Talya, Sharma, Neeraj, Lederkremer, Gerardo Z.
Publicado 2019

PERK Pathway and Neurodegenerative Disease: To Inhibit or to Activate?

por Shacham, Talya, Patel, Chaitanya, Lederkremer, Gerardo Z.
Publicado 2021

Oxidoreductases in Glycoprotein Glycosylation, Folding, and ERAD

por Patel, Chaitanya, Saad, Haddas, Shenkman, Marina, Lederkremer, Gerardo Z.
Publicado 2020

Bypass of glycan-dependent glycoprotein delivery to ERAD by up-regulated EDEM1

por Ron, Efrat, Shenkman, Marina, Groisman, Bella, Izenshtein, Yana, Leitman, Julia, Lederkremer, Gerardo Z.
Publicado 2011

Mannosidase activity of EDEM1 and EDEM2 depends on an unfolded state of their glycoprotein substrates

por Shenkman, Marina, Ron, Efrat, Yehuda, Rivka, Benyair, Ron, Khalaila, Isam, Lederkremer, Gerardo Z.
Publicado 2018

The role of RNF149 in the pre-emptive quality control substrate ubiquitination

por Legesse, Aster, Kaushansky, Nathali, Braunstein, Ilana, Saad, Haddas, Lederkremer, Gerardo, Navon, Ami, Stanhill, Ariel
Publicado 2023

Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates

por Benyair, Ron, Ogen-Shtern, Navit, Mazkereth, Niv, Shai, Ben, Ehrlich, Marcelo, Lederkremer, Gerardo Z.
Publicado 2015

The Sigma-1 receptor is an ER-localized type II membrane protein

por Sharma, Neeraj, Patel, Chaitanya, Shenkman, Marina, Kessel, Amit, Ben-Tal, Nir, Lederkremer, Gerardo Z.
Publicado 2021

ER Stress-Induced eIF2-alpha Phosphorylation Underlies Sensitivity of Striatal Neurons to Pathogenic Huntingtin

por Leitman, Julia, Barak, Boaz, Benyair, Ron, Shenkman, Marina, Ashery, Uri, Hartl, F. Ulrich, Lederkremer, Gerardo Z.
Publicado 2014

COP I and II dependent trafficking controls ER-associated degradation in mammalian cells

por Ogen-Shtern, Navit, Chang, Chieh, Saad, Haddas, Mazkereth, Niv, Patel, Chaitanya, Shenkman, Marina, Lederkremer, Gerardo Z.
Publicado 2023

Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD

por Leitman, Julia, Shenkman, Marina, Gofman, Yana, Shtern, Navit Ogen, Ben-Tal, Nir, Hendershot, Linda M., Lederkremer, Gerardo Z.
Publicado 2014

A Secreted Form of the Asialoglycoprotein Receptor, sH2a, as a Novel Potential Noninvasive Marker for Liver Fibrosis

por Veselkin, Elena, Kondratyev, Maria, Lurie, Yoav, Ron, Efrat, Santo, Moshe, Reif, Shimon, Elashvili, Irma, Bar, Lana, Lederkremer, Gerardo Z.
Publicado 2011

A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models

por Ganz, Javier, Shacham, Talya, Kramer, Maria, Shenkman, Marina, Eiger, Hagit, Weinberg, Nitai, Iancovici, Ori, Roy, Somnath, Simhaev, Luba, Da’adoosh, Benny, Engel, Hamutal, Perets, Nisim, Barhum, Yael, Portnoy, Moshe, Offen, Daniel, Lederkremer, Gerardo Z.
Publicado 2020