Lipid dynamics at dendritic spines

por Dotti, Carlos Gerardo, Esteban, Jose Antonio, Ledesma, María Dolores
Publicado 2014

Editorial: Lipids in the Brain

por Albi, Elisabetta, Alessenko, Alice Vladimirovna, Elahi, Fanny M., Ledesma, Maria Dolores
Publicado 2020

Sphingomyelin 16:0 is a therapeutic target for neuronal death in acid sphingomyelinase deficiency

por Gaudioso, Ángel, Jiang, Xuntian, Casas, Josefina, Schuchman, Edward H., Ledesma, María Dolores
Publicado 2023

Modulation of Dietary Choline Uptake in a Mouse Model of Acid Sphingomyelinase Deficiency

por Gaudioso, Ángel, Moreno-Huguet, Pilar, Casas, Josefina, Schuchman, Edward H., Ledesma, María Dolores
Publicado 2023

Prion Protein Accumulation in Lipid Rafts of Mouse Aging Brain

por Agostini, Federica, Dotti, Carlos G., Pérez-Cañamás, Azucena, Ledesma, Maria Dolores, Benetti, Federico, Legname, Giuseppe
Publicado 2013

Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

por Bartoll, Adrián, Toledano‐Zaragoza, Ana, Casas, Josefina, Guzmán, Manuel, Schuchman, Edward H, Ledesma, María Dolores
Publicado 2020

SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production

por Mitroi, Daniel N., Karunakaran, Indulekha, Gräler, Markus, Saba, Julie D., Ehninger, Dan, Ledesma, María Dolores, van Echten-Deckert, Gerhild
Publicado 2017

NPC1 enables cholesterol mobilization during long‐term potentiation that can be restored in Niemann–Pick disease type C by CYP46A1 activation

por Mitroi, Daniel N, Pereyra‐Gómez, Guadalupe, Soto‐Huelin, Beatriz, Senovilla, Fernando, Kobayashi, Toshihide, Esteban, Jose A, Ledesma, María Dolores
Publicado 2019

Neuronal membrane cholesterol loss enhances amyloid peptide generation

por Abad-Rodriguez, Jose, Ledesma, Maria Dolores, Craessaerts, Katleen, Perga, Simona, Medina, Miguel, Delacourte, Andre, Dingwall, Colin, De Strooper, Bart, Dotti, Carlos G.
Publicado 2004

Synaptic Vesicle Docking: Sphingosine Regulates Syntaxin1 Interaction with Munc18

por Camoletto, Paola G., Vara, Hugo, Morando, Laura, Connell, Emma, Marletto, Fabio P., Giustetto, Maurizio, Sassoè-Pognetto, Marco, Van Veldhoven, Paul P., Ledesma, Maria Dolores
Publicado 2009

Lipid‐induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders

por Gabandé‐Rodríguez, Enrique, Pérez‐Cañamás, Azucena, Soto‐Huelin, Beatriz, Mitroi, Daniel N, Sánchez‐Redondo, Sara, Martínez‐Sáez, Elena, Venero, César, Peinado, Héctor, Ledesma, María Dolores
Publicado 2018

Efficacy and safety clinical trial with efavirenz in patients diagnosed with adult Niemann-pick type C with cognitive impairment

por Gascón-Bayarri, Jordi, Simon, Petru Cristian, Llop, Roser, Carnaval, Thiago, Ledesma, María Dolores, Rico, Imma, Sánchez-Castañeda, Cristina, Campdelacreu-Fumadó, Jaume, Calvo-Malvar, Nahum, Cos, Mònica, de Lama, Eugenia, Cortés-Romera, Montserrat, Rodríguez-Bel, Laura, Pérez-Sousa, Celia, Cerdán Sánchez, María, Muelas, Nuria, Sevillano, María Dolores, Mir, Pablo, López de Munain, Adolfo, Ferrer, Anna, Videla, Sebastián
Publicado 2022

CERT(L) reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease

por Crivelli, Simone M., Luo, Qian, Stevens, Jo A.A., Giovagnoni, Caterina, van Kruining, Daan, Bode, Gerard, den Hoedt, Sandra, Hobo, Barbara, Scheithauer, Anna-Lena, Walter, Jochen, Mulder, Monique T., Exley, Christopher, Mold, Matthew, Mielke, Michelle M., De Vries, Helga E., Wouters, Kristiaan, van den Hove, Daniel L. A., Berkes, Dusan, Ledesma, María Dolores, Verhaagen, Joost, Losen, Mario, Bieberich, Erhard, Martinez-Martinez, Pilar
Publicado 2021

Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

por Kalinichenko, Liubov S., Mühle, Christiane, Jia, Tianye, Anderheiden, Felix, Datz, Maria, Eberle, Anna-Lisa, Eulenburg, Volker, Granzow, Jonas, Hofer, Martin, Hohenschild, Julia, Huber, Sabine E., Kämpf, Stefanie, Kogias, Georgios, Lacatusu, Laura, Lugmair, Charlotte, Taku, Stephen Mbu, Meixner, Doris, Tesch, Nina, Praetner, Marc, Rhein, Cosima, Sauer, Christina, Scholz, Jessica, Ulrich, Franziska, Valenta, Florian, Weigand, Esther, Werner, Markus, Tay, Nicole, Mc Veigh, Conor J., Haase, Jana, Wang, An-Li, Abdel-Hafiz, Laila, Huston, Joseph P., Smaga, Irena, Frankowska, Malgorzata, Filip, Malgorzata, Lourdusamy, Anbarasu, Kirchner, Philipp, Ekici, Arif B., Marx, Lena M., Suresh, Neeraja Puliparambil, Frischknecht, Renato, Fejtova, Anna, Saied, Essa M., Arenz, Christoph, Bozec, Aline, Wank, Isabel, Kreitz, Silke, Hess, Andreas, Bäuerle, Tobias, Ledesma, Maria Dolores, Mitroi, Daniel N., Miranda, André M., Oliveira, Tiago G., Gulbins, Erich, Lenz, Bernd, Schumann, Gunter, Kornhuber, Johannes, Müller, Christian P.
Publicado 2021