Disease Mechanisms and Therapeutic Approaches in C9orf72 ALS-FTD

por Mayl, Keith, Shaw, Christopher E., Lee, Youn-Bok
Publicado 2021

Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells)

por Howarth, Joanna L., Lee, Youn Bok, Uney, James B.
Publicado 2009

RNA Misprocessing in C9orf72-Linked Neurodegeneration

por Barker, Holly V., Niblock, Michael, Lee, Youn-Bok, Shaw, Christopher E., Gallo, Jean-Marc
Publicado 2017

Twist-1 regulates the miR-199a/214 cluster during development

por Lee, Youn-Bok, Bantounas, Ioannis, Lee, Do-Young, Phylactou, Leonidas, Caldwell, Maeve A., Uney, James B.
Publicado 2009

MiR-3120 Is a Mirror MicroRNA That Targets Heat Shock Cognate Protein 70 and Auxilin Messenger RNAs and Regulates Clathrin Vesicle Uncoating

por Scott, Helen, Howarth, Joanna, Lee, Youn Bok, Wong, Liang-Fong, Bantounas, Ioannis, Phylactou, Leonidas, Verkade, Paul, Uney, James. B.
Publicado 2012

Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their...

por Gomez-Deza, Jorge, Lee, Youn-bok, Troakes, Claire, Nolan, Matthew, Al-Sarraj, Safa, Gallo, Jean-Marc, Shaw, Christopher E.
Publicado 2015

Cytoplasmic TDP-43 is involved in cell fate during stress recovery

por Lee, Youn-Bok, Scotter, Emma L, Lee, Do-Young, Troakes, Claire, Mitchell, Jacqueline, Rogelj, Boris, Gallo, Jean-Marc, Shaw, Christopher E
Publicado 2021

iCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function

por Rivers, Caroline, Idris, Jalilah, Scott, Helen, Rogers, Mark, Lee, Youn-Bok, Gaunt, Jessica, Phylactou, Leonidas, Curk, Tomaz, Campbell, Colin, Ule, Jernej, Norman, Michael, Uney, James B.
Publicado 2015

MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex

por Scott, Helen L, Tamagnini, Francesco, Narduzzo, Katherine E, Howarth, Joanna L, Lee, Youn-Bok, Wong, Liang-Fong, Brown, Malcolm W, Warburton, Elizabeth C, Bashir, Zafar I, Uney, James B
Publicado 2012

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

por Scotter, Emma L., Vance, Caroline, Nishimura, Agnes L., Lee, Youn-Bok, Chen, Han-Jou, Urwin, Hazel, Sardone, Valentina, Mitchell, Jacqueline C., Rogelj, Boris, Rubinsztein, David C., Shaw, Christopher E.
Publicado 2014

Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA

por Božič, Janja, Motaln, Helena, Janež, Anja Pucer, Markič, Lara, Tripathi, Priyanka, Yamoah, Alfred, Aronica, Eleonora, Lee, Youn-Bok, Heilig, Raphael, Fischer, Roman, Thompson, Andrew J, Goswami, Anand, Rogelj, Boris
Publicado 2021

Retention of hexanucleotide repeat-containing intron in C9orf72 mRNA: implications for the pathogenesis of ALS/FTD

por Niblock, Michael, Smith, Bradley N., Lee, Youn-Bok, Sardone, Valentina, Topp, Simon, Troakes, Claire, Al-Sarraj, Safa, Leblond, Claire S., Dion, Patrick A., Rouleau, Guy A., Shaw, Christopher E., Gallo, Jean-Marc
Publicado 2016

Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells

por Nishimura, Agnes L., Shum, Carole, Scotter, Emma L., Abdelgany, Amr, Sardone, Valentina, Wright, Jamie, Lee, Youn-Bok, Chen, Han-Jou, Bilican, Bilada, Carrasco, Monica, Maniatis, Tom, Chandran, Siddharthan, Rogelj, Boris, Gallo, Jean-Marc, Shaw, Christopher E.
Publicado 2014

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity

por Lee, Youn-Bok, Baskaran, Pranetha, Gomez-Deza, Jorge, Chen, Han-Jou, Nishimura, Agnes L, Smith, Bradley N, Troakes, Claire, Adachi, Yoshitsugu, Stepto, Alan, Petrucelli, Leonard, Gallo, Jean-Marc, Hirth, Frank, Rogelj, Boris, Guthrie, Sarah, Shaw, Christopher E
Publicado 2017

Expanded G4C2 repeats linked to C9ORF72 ALS and FTD form length-dependent RNA foci, sequester RNA binding proteins and are neurotoxic

por Lee, Youn-Bok, Chen, Han-Jou, Peres, João N, Gomez, Jorge, Sardone, Valentina, Nishimura, Agnes L, Scotter, Emma, Vance, Caroline, Štalekar, Maja, Adachi, Yoshitsugu, Troakes, Claire, Miller, Jack, Smith, Bradley, Hirth, Frank, Rogelj, Boris, Houart, Corinne, Shaw, Christopher E
Publicado 2013

Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic

por Lee, Youn-Bok, Chen, Han-Jou, Peres, João N., Gomez-Deza, Jorge, Attig, Jan, Štalekar, Maja, Troakes, Claire, Nishimura, Agnes L., Scotter, Emma L., Vance, Caroline, Adachi, Yoshitsugu, Sardone, Valentina, Miller, Jack W., Smith, Bradley N., Gallo, Jean-Marc, Ule, Jernej, Hirth, Frank, Rogelj, Boris, Houart, Corinne, Shaw, Christopher E.
Publicado 2013

A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration

por Solomon, Daniel A, Stepto, Alan, Au, Wing Hei, Adachi, Yoshitsugu, Diaper, Danielle C, Hall, Rachel, Rekhi, Anjeet, Boudi, Adel, Tziortzouda, Paraskevi, Lee, Youn-Bok, Smith, Bradley, Bridi, Jessika C, Spinelli, Greta, Dearlove, Jonah, Humphrey, Dickon M, Gallo, Jean-Marc, Troakes, Claire, Fanto, Manolis, Soller, Matthias, Rogelj, Boris, Parsons, Richard B, Shaw, Christopher E, Hortobágyi, Tibor, Hirth, Frank
Publicado 2018

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca(2+)-permeable AMPA receptor-mediated excitotoxicity

por Selvaraj, Bhuvaneish T., Livesey, Matthew R., Zhao, Chen, Gregory, Jenna M., James, Owain T., Cleary, Elaine M., Chouhan, Amit K., Gane, Angus B., Perkins, Emma M., Dando, Owen, Lillico, Simon G., Lee, Youn-Bok, Nishimura, Agnes L., Poreci, Urjana, Thankamony, Sai, Pray, Meryll, Vasistha, Navneet A., Magnani, Dario, Borooah, Shyamanga, Burr, Karen, Story, David, McCampbell, Alexander, Shaw, Christopher E., Kind, Peter C., Aitman, Timothy J., Whitelaw, C. Bruce A., Wilmut, Ian, Smith, Colin, Miles, Gareth B., Hardingham, Giles E., Wyllie, David J. A., Chandran, Siddharthan
Publicado 2018