Isorhamnetin Attenuated the Release of Interleukin-6 from β-Amyloid-Activated Microglia and Mitigated Interleukin-6-Mediated Neurotoxicity

por Wei, Pei-Cih, Lee-Chen, Guey-Jen, Chen, Chiung-Mei, Chen, Ying, Lo, Yen-Shi, Chang, Kuo-Hsuan
Publicado 2022

Role of High Mobility Group Box 1 (HMGB1) in SCA17 Pathogenesis

por Lee, Li-Ching, Chen, Chiung-Mei, Wang, Pin-Rong, Su, Ming-Tsan, Lee-Chen, Guey-Jen, Chang, Chun-Yen
Publicado 2014

STK39, But Not BST1, HLA-DQB1, and SPPL2B Polymorphism, Is Associated With Han-Chinese Parkinson's Disease in Taiwan

por Chang, Kuo-Hsuan, Wu, Yih-Ru, Chen, Yi-Chun, Fung, Hon-Chung, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Publicado 2015

Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSC-Derived Neurons

por Chen, I-Cheng, Chang, Kuo-Hsuan, Chen, Yi-Jing, Chen, Yi-Chun, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Publicado 2019

Genetic Analysis of EGLN1 C127S Variant in Taiwanese Parkinson's Disease

por Chiang, Han-Lin, Chen, Chiung Mei, Chen, Yi-Chun, Chao, Chih-Ying, Wu, Yih-Ru, Lee-Chen, Guey-Jen
Publicado 2020

Rare VPS35 A320V Variant in Taiwanese Parkinson’s Disease Indicates Disrupted CI-MPR Sorting and Impaired Mitochondrial Morphology

por Wu, Yih-Ru, Lin, Chih-Hsin, Chao, Chih-Ying, Chang, Chia-Wen, Chen, Chiung-Mei, Lee-Chen, Guey-Jen
Publicado 2020

Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17

por Huang, Ding-Siang, Lin, Hsuan-Yuan, Lee-Chen, Guey-Jen, Hsieh-Li, Hsiu-Mei, Wu, Chung-Hsin, Lin, Jung-Yaw
Publicado 2016

Pathomechanism Characterization and Potential Therapeutics Identification for Parkinson’s Disease Targeting Neuroinflammation

por Chen, Chiung-Mei, Yen, Chien-Yu, Chen, Wan-Ling, Lin, Chih-Hsin, Wu, Yih-Ru, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen
Publicado 2021

A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment

por Chiu, Ya-Jen, Teng, Yu-Shan, Chen, Chiung-Mei, Sun, Ying-Chieh, Hsieh-Li, Hsiu Mei, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen
Publicado 2023

Association of TNF-α gene with spontaneous deep intracerebral hemorrhage in the Taiwan population: a case control study

por Chen, Yi-Chun, Hu, Fen-Ju, Chen, Phoebe, Wu, Yih-Ru, Wu, Hsiu-Chuan, Chen, Sien-Tsong, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Publicado 2010

Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protei...

por Lin, Te-Hsien, Chang, Kuo-Hsuan, Chiu, Ya-Jen, Weng, Zheng-Kui, Sun, Ying-Chieh, Lin, Wenwei, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Publicado 2022

Exendin-4 Protected against Cognitive Dysfunction in Hyperglycemic Mice Receiving an Intrahippocampal Lipopolysaccharide Injection

por Huang, Hei-Jen, Chen, Yen-Hsu, Liang, Keng-Chen, Jheng, Yu-Syuan, Jhao, Jhih-Jhen, Su, Ming-Tsan, Lee-Chen, Guey-Jen, Hsieh-Li, Hsiu Mei
Publicado 2012

Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

por Huang, Hei-Jen, Chen, Shu-Ling, Huang, Hsin-Yu, Sun, Ying-Chieh, Lee, Guan-Chiun, Lee-Chen, Guey-Jen, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan
Publicado 2018

Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer’s disease cell and mouse models for neuroprotection and cognitive improvement

por Chiu, Ya-Jen, Lin, Chih-Hsin, Lee, Ming-Chung, Hsieh-Li, Hsiu Mei, Chen, Chiung-Mei, Wu, Yih-Ru, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen
Publicado 2021

Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population

por Chang, Kuo-Hsuan, Chen, Chiung-Mei, Chen, Yi-Chun, Hsiao, Ya-Chin, Huang, Chin-Chang, Kuo, Hung-Chou, Hsu, Hsuan-Chu, Lee-Chen, Guey-Jen, Wu, Yih-Ru
Publicado 2013

Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation

por Chen, I-Cheng, Lin, Te-Hsien, Hsieh, Yu-Hsuan, Chao, Chih-Ying, Wu, Yih-Ru, Chang, Kuo-Hsuan, Lee, Ming-Chung, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Publicado 2018

Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models

por Wei, Pei-Cih, Lee-Chen, Guey-Jen, Chen, Chiung-Mei, Wu, Yih-Ru, Chen, Yi-Jing, Lin, Jia-Li, Lo, Yen-Shi, Yao, Ching-Fa, Chang, Kuo-Hsuan
Publicado 2019

Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity

por Chiu, Ya-Jen, Lin, Te-Hsien, Chang, Kuo-Hsuan, Lin, Wenwei, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan, Chen, Chiung-Mei, Sun, Ying-Chieh, Lee-Chen, Guey-Jen
Publicado 2022

Spinocerebellar ataxia type 8 larger triplet expansion alters histone modification and induces RNA foci

por Chen, I-Cheng, Lin, Hsuan-Yuan, Lee, Ghin-Chueh, Kao, Shih-Huan, Chen, Chiung-Mei, Wu, Yih-Ru, Hsieh-Li, Hsiu-Mei, Su, Ming-Tsan, Lee-Chen, Guey-Jen
Publicado 2009

New Synthetic 3-Benzoyl-5-Hydroxy-2H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AM...

por Chen, Chiung-Mei, Chen, Wan-Ling, Yang, Shu-Ting, Lin, Te-Hsien, Yang, Shu-Mei, Lin, Wenwei, Chao, Chih-Ying, Wu, Yih-Ru, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen
Publicado 2020