Tracking hematopoietic stem cells and their progeny using whole-genome sequencing

por Lee-Six, Henry, Kent, David G.
Publicado 2020

Population dynamics of normal human blood inferred from somatic mutations

por Lee-Six, Henry, Øbro, Nina Friesgaard, Shepherd, Mairi S., Grossmann, Sebastian, Dawson, Kevin, Belmonte, Miriam, Osborne, Robert J., Huntly, Brian J. P., Martincorena, Inigo, Anderson, Elizabeth, O’Neill, Laura, Stratton, Michael R., Laurenti, Elisa, Green, Anthony R., Kent, David G., Campbell, Peter J.
Publicado 2018

Somatic Evolution in Non-neoplastic IBD-Affected Colon

por Olafsson, Sigurgeir, McIntyre, Rebecca E., Coorens, Tim, Butler, Timothy, Jung, Hyunchul, Robinson, Philip S., Lee-Six, Henry, Sanders, Mathijs A., Arestang, Kenneth, Dawson, Claire, Tripathi, Monika, Strongili, Konstantina, Hooks, Yvette, Stratton, Michael R., Parkes, Miles, Martincorena, Inigo, Raine, Tim, Campbell, Peter J., Anderson, Carl A.
Publicado 2020

Discovery and Features of an Alkylating Signature in Colorectal Cancer

por Gurjao, Carino, Zhong, Rong, Haruki, Koichiro, Li, Yvonne Y., Spurr, Liam F., Lee-Six, Henry, Reardon, Brendan, Ugai, Tomotaka, Zhang, Xuehong, Cherniack, Andrew D., Song, Mingyang, Van Allen, Eliezer M., Meyerhardt, Jeffrey A., Nowak, Jonathan A., Giovannucci, Edward L., Fuchs, Charles S., Wu, Kana, Ogino, Shuji, Giannakis, Marios
Publicado 2021

Increased somatic mutation burdens in normal human cells due to defective DNA polymerases

por Robinson, Philip S., Coorens, Tim H. H., Palles, Claire, Mitchell, Emily, Abascal, Federico, Olafsson, Sigurgeir, Lee, Bernard C. H., Lawson, Andrew R. J., Lee-Six, Henry, Moore, Luiza, Sanders, Mathijs A., Hewinson, James, Martin, Lynn, Pinna, Claudia M. A., Galavotti, Sara, Rahbari, Raheleh, Campbell, Peter J., Martincorena, Iñigo, Tomlinson, Ian, Stratton, Michael R.
Publicado 2021

Tobacco exposure and somatic mutations in normal human bronchial epithelium

por Yoshida, Kenichi, Gowers, Kate HC, Lee-Six, Henry, Chandrasekharan, Deepak P, Coorens, Tim, Maughan, Elizabeth F, Beal, Kathryn, Menzies, Andrew, Millar, Fraser R, Anderson, Elizabeth, Clarke, Sarah E, Pennycuick, Adam, Thakrar, Ricky M, Butler, Colin R, Kakiuchi, Nobuyuki, Hirano, Tomonori, Hynds, Robert E, Stratton, Michael R, Martincorena, Inigo, Janes, Sam M, Campbell, Peter J
Publicado 2020

APOBEC mutagenesis is a common process in normal human small intestine

por Wang, Yichen, Robinson, Philip S., Coorens, Tim H. H., Moore, Luiza, Lee-Six, Henry, Noorani, Ayesha, Sanders, Mathijs A., Jung, Hyunchul, Katainen, Riku, Heuschkel, Robert, Brunton-Sim, Roxanne, Weston, Robyn, Read, Debbie, Nobbs, Beverley, Fitzgerald, Rebecca C., Saeb-Parsy, Kourosh, Martincorena, Iñigo, Campbell, Peter J., Rushbrook, Simon, Zilbauer, Matthias, Buczacki, Simon James Alexander, Stratton, Michael R.
Publicado 2023

Targetable NOTCH1 rearrangements in reninoma

por Treger, Taryn D., Lawrence, John E. G., Anderson, Nathaniel D., Coorens, Tim H. H., Letunovska, Aleksandra, Abby, Emilie, Lee-Six, Henry, Oliver, Thomas R. W., Al-Saadi, Reem, Tullus, Kjell, Morcrette, Guillaume, Hutchinson, J. Ciaran, Rampling, Dyanne, Sebire, Neil, Pritchard-Jones, Kathy, Young, Matthew D., Mitchell, Thomas J., Jones, Philip H., Tran, Maxine, Behjati, Sam, Chowdhury, Tanzina
Publicado 2023

Mutational landscape of normal epithelial cells in Lynch Syndrome patients

por Lee, Bernard C. H., Robinson, Philip S., Coorens, Tim H. H., Yan, Helen H. N., Olafsson, Sigurgeir, Lee-Six, Henry, Sanders, Mathijs A., Siu, Hoi Cheong, Hewinson, James, Yue, Sarah S. K., Tsui, Wai Yin, Chan, Annie S. Y., Chan, Anthony K. W., Ho, Siu Lun, Campbell, Peter J., Martincorena, Inigo, Buczacki, Simon J. A., Yuen, Siu Tsan, Leung, Suet Yi, Stratton, Michael R.
Publicado 2022

Clonal dynamics of haematopoiesis across the human lifespan

por Mitchell, Emily, Spencer Chapman, Michael, Williams, Nicholas, Dawson, Kevin J., Mende, Nicole, Calderbank, Emily F., Jung, Hyunchul, Mitchell, Thomas, Coorens, Tim H. H., Spencer, David H., Machado, Heather, Lee-Six, Henry, Davies, Megan, Hayler, Daniel, Fabre, Margarete A., Mahbubani, Krishnaa, Abascal, Federico, Cagan, Alex, Vassiliou, George S., Baxter, Joanna, Martincorena, Inigo, Stratton, Michael R., Kent, David G., Chatterjee, Krishna, Parsy, Kourosh Saeb, Green, Anthony R., Nangalia, Jyoti, Laurenti, Elisa, Campbell, Peter J.
Publicado 2022

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells

por Robinson, Philip S., Thomas, Laura E., Abascal, Federico, Jung, Hyunchul, Harvey, Luke M. R., West, Hannah D., Olafsson, Sigurgeir, Lee, Bernard C. H., Coorens, Tim H. H., Lee-Six, Henry, Butlin, Laura, Lander, Nicola, Truscott, Rebekah, Sanders, Mathijs A., Lensing, Stefanie V., Buczacki, Simon J. A., ten Hoopen, Rogier, Coleman, Nicholas, Brunton-Sim, Roxanne, Rushbrook, Simon, Saeb-Parsy, Kourosh, Lalloo, Fiona, Campbell, Peter J., Martincorena, Iñigo, Sampson, Julian R., Stratton, Michael R.
Publicado 2022