Measuring stem cell dynamics in the human colon – where there’s a wiggle, there’s a way†

por Leedham, Simon J
Publicado 2014

Intestine, Heal Thyself! Regulating the Intestinal Epithelial Response to Injury

por Leedham, Simon J.
Publicado 2020

Gremlin 1 — small protein, big impact: the multiorgan consequences of disrupted BMP antagonism(†)

por Gooding, Sarah, Leedham, Simon J
Publicado 2020

Not All Wnt Activation Is Equal: Ligand-Dependent versus Ligand-Independent Wnt Activation in Colorectal Cancer

por Kleeman, Sam O., Leedham, Simon J.
Publicado 2020

Advances in colon cancer research: in vitro and animal models

por Lannagan, Tamsin RM, Jackstadt, Rene, Leedham, Simon J, Sansom, Owen J
Publicado 2021

Stromal composition predicts recurrence of early rectal cancer after local excision

por Jones, Helen J S, Cunningham, Chris, Askautrud, Hanne A, Danielsen, Håvard E, Kerr, David J, Domingo, Enric, Maughan, Tim, Leedham, Simon J, Koelzer, Viktor H
Publicado 2021

Germline variant testing in serrated polyposis syndrome

por Murphy, Aisling, Solomons, Joyce, Risby, Peter, Gabriel, Jessica, Bedenham, Tina, Johnson, Michael, Atkinson, Nathan, Bailey, Adam A, Bird‐Lieberman, Elizabeth, Leedham, Simon J, East, James E, Biswas, Sujata
Publicado 2022

British Society of Gastroenterology position statement on serrated polyps in the colon and rectum

por East, James E, Atkin, Wendy S, Bateman, Adrian C, Clark, Susan K, Dolwani, Sunil, Ket, Shara N, Leedham, Simon J, Phull, Perminder S, Rutter, Matt D, Shepherd, Neil A, Tomlinson, Ian, Rees, Colin J
Publicado 2017

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

por Leedham, Simon J, Rodenas-Cuadrado, Pedro, Howarth, Kimberley, Lewis, Annabelle, Mallappa, Sreelakshmi, Segditsas, Stefania, Davis, Hayley, Jeffery, Rosemary, Rodriguez-Justo, Manuel, Keshav, Satish, Travis, Simon P L, Graham, Trevor A, East, James, Clark, Susan, Tomlinson, Ian P M
Publicado 2013

Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration

por Koppens, Martijn A. J., Davis, Hayley, Valbuena, Gabriel N., Mulholland, Eoghan J., Nasreddin, Nadia, Colombe, Mathilde, Antanaviciute, Agne, Biswas, Sujata, Friedrich, Matthias, Lee, Lennard, Wang, Lai Mun, Koelzer, Viktor H., East, James E., Simmons, Alison, Winton, Douglas J., Leedham, Simon J.
Publicado 2021

Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues

por Gabbutt, Calum, Schenck, Ryan O., Weisenberger, Daniel J., Kimberley, Christopher, Berner, Alison, Househam, Jacob, Lakatos, Eszter, Robertson-Tessi, Mark, Martin, Isabel, Patel, Roshani, Clark, Susan K., Latchford, Andrew, Barnes, Chris P., Leedham, Simon J., Anderson, Alexander R. A., Graham, Trevor A., Shibata, Darryl
Publicado 2022

Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning

por Sirinukunwattana, Korsuk, Domingo, Enric, Richman, Susan D, Redmond, Keara L, Blake, Andrew, Verrill, Clare, Leedham, Simon J, Chatzipli, Aikaterini, Hardy, Claire, Whalley, Celina M, Wu, Chieh-hsi, Beggs, Andrew D, McDermott, Ultan, Dunne, Philip D, Meade, Angela, Walker, Steven M, Murray, Graeme I, Samuel, Leslie, Seymour, Matthew, Tomlinson, Ian, Quirke, Phil, Maughan, Timothy, Rittscher, Jens, Koelzer, Viktor H
Publicado 2021

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

por Kleeman, Sam O, Koelzer, Viktor H, Jones, Helen JS, Vazquez, Ester Gil, Davis, Hayley, East, James E, Arnold, Roland, Koppens, Martijn AJ, Blake, Andrew, Domingo, Enric, Cunningham, Chris, Beggs, Andrew D, Pestinger, Valerie, Loughrey, Maurice B, Wang, Lai-Mun, Lannagan, Tamsin RM, Woods, Susan L, Worthley, Daniel, Consortium, S:CORT, Tomlinson, Ian, Dunne, Philip D, Maughan, Timothy, Leedham, Simon J
Publicado 2020

Evolutionary history of human colitis-associated colorectal cancer

por Baker, Ann-Marie, Cross, William, Curtius, Kit, Al Bakir, Ibrahim, Choi, Chang-Ho Ryan, Davis, Hayley Louise, Temko, Daniel, Biswas, Sujata, Martinez, Pierre, Williams, Marc J, Lindsay, James O, Feakins, Roger, Vega, Roser, Hayes, Stephen J, Tomlinson, Ian P M, McDonald, Stuart A C, Moorghen, Morgan, Silver, Andrew, East, James E, Wright, Nicholas A, Wang, Lai Mun, Rodriguez-Justo, Manuel, Jansen, Marnix, Hart, Ailsa L, Leedham, Simon J, Graham, Trevor A
Publicado 2019

The evolutionary landscape of colorectal tumorigenesis

por Cross, William, Kovac, Michal, Mustonen, Ville, Temko, Daniel, Davis, Hayley, Baker, Ann-Marie, Biswas, Sujata, Arnold, Roland, Chegwidden, Laura, Gatenbee, Chandler, Anderson, Alexander R, Koelzer, Viktor H, Martinez, Pierre, Jiang, Xiaowei, Domingo, Enric, Woodcock, Dan, Feng, Yun, Kovacova, Monika, Maughan, Tim, Jansen, Marnix, Rodriguez-Justo, Manuel, Ashraf, Shazad, Guy, Richard, Cunningham, Christopher, East, James E, Wedge, David C, Wang, Lai Mun, Palles, Claire, Heinimann, Karl, Sottoriva, Andrea, Leedham, Simon J, Graham, Trevor A, Tomlinson, Ian PM
Publicado 2018

β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

por Suzuki, Toshiyasu, Kilbey, Anna, Casa-Rodríguez, Nuria, Lawlor, Amy, Georgakopoulou, Anastasia, Hayman, Hannah, Yin Swe, Kyi Lai, Nordin, Anna, Cantù, Claudio, Vantourout, Pierre, Ridgway, Rachel A., Byrne, Ryan M., Chen, Lei, Verzi, Michael P., Gay, David M., Gil Vázquez, Ester, Belnoue-Davis, Hayley L., Gilroy, Kathryn, Køstner, Anne Helene, Kersten, Christian, Thuwajit, Chanitra, Andersen, Ditte K., Wiesheu, Robert, Jandke, Anett, Blyth, Karen, Roseweir, Antonia K., Leedham, Simon J., Dunne, Philip D., Edwards, Joanne, Hayday, Adrian, Sansom, Owen J., Coffelt, Seth B.
Publicado 2023

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

por Gil Vazquez, Ester, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.
Publicado 2022

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

por Gil Vazquez, Ester, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.
Publicado 2022

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

por Leach, Joshua D. G., Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A., Flanagan, Dustin J., Gilroy, Kathryn, Sphyris, Nathalie, Vázquez, Ester G., Vincent, David F., Faller, William J., Hodder, Michael C., Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K., Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, van Hooff, Sander R., Huels, David J., Medema, Jan Paul, Barry, Simon T., Frame, Margaret C., Unciti-Broceta, Asier, Leedham, Simon J., Inman, Gareth J., Jackstadt, Rene, Thompson, Barry J., Campbell, Andrew D., Tejpar, Sabine, Sansom, Owen J.
Publicado 2021

Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

por Beach, Callum, MacLean, David, Majorova, Dominika, Melemenidis, Stavros, Nambiar, Dhanya K., Kim, Ryan K., Valbuena, Gabriel N., Guglietta, Silvia, Krieg, Carsten, Darvish-Damavandi, Mahnaz, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Domingo, Enric, Moon, Eui Jung, Jiang, Dadi, Jiang, Yanyan, Zhang, Qingyang, Koong, Albert C., Woodruff, Trent M., Graves, Edward E., Maughan, Tim, Buczacki, Simon J.A., Stucki, Manuel, Le, Quynh-Thu, Leedham, Simon J., Giaccia, Amato J., Olcina, Monica M.
Publicado 2023