DNA Double Strand Break Repair in Mitosis Is Suppressed by Phosphorylation of XRCC4

por Lees-Miller, Susan P.
Publicado 2014

Unraveling the roles of WRN and DNA-PKcs at telomeres

por Beattie, Tara L., Lees-Miller, Susan P.
Publicado 2010

Predicting PARP inhibitor sensitivity and resistance

por Bebb, D. Gwyn, Lees-Miller, Susan P.
Publicado 2012

How to fix DNA breaks: new insights into the mechanism of non-homologous end joining

por Vogt, Alex, He, Yuan, Lees-Miller, Susan P.
Publicado 2023

N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku

por Meek, Katheryn, Lees-Miller, Susan P., Modesti, Mauro
Publicado 2012

Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy

por Ye, Zu, Shi, Yin, Lees-Miller, Susan P., Tainer, John A.
Publicado 2021

Structural insights into the role of DNA-PK as a master regulator in NHEJ

por Chen, Siyu, Lees-Miller, James P., He, Yuan, Lees-Miller, Susan P.
Publicado 2021

ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib()

por Wang, Chen, Jette, Nicholas, Moussienko, Daniel, Bebb, D. Gwyn, Lees-Miller, Susan P.
Publicado 2017

Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase

por Ting, Nicholas S. Y., Yu, Yaping, Pohorelic, Brant, Lees-Miller, Susan P., Beattie, Tara L.
Publicado 2005

The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1

por Ting, Nicholas S. Y., Pohorelic, Brant, Yu, Yaping, Lees-Miller, Susan P., Beattie, Tara L.
Publicado 2009

Phosphorylation in the serine/threonine 2609–2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extr...

por Povirk, Lawrence F., Zhou, Rui-Zhe, Ramsden, Dale A., Lees-Miller, Susan P., Valerie, Kristoffer
Publicado 2007

Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ

por Chen, Siyu, Vogt, Alex, Lee, Linda, Naila, Tasmin, McKeown, Ryan, Tomkinson, Alan E, Lees-Miller, Susan P, He, Yuan
Publicado 2023

Nej1 Interacts with Mre11 to Regulate Tethering and Dna2 Binding at DNA Double-Strand Breaks

por Mojumdar, Aditya, Sorenson, Kyle, Hohl, Marcel, Toulouze, Mathias, Lees-Miller, Susan P., Dubrana, Karine, Petrini, John H.J., Cobb, Jennifer A.
Publicado 2019

Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis

por Douglas, Pauline, Ye, Ruiqiong, Trinkle-Mulcahy, Laura, Neal, Jessica A., De Wever, Veerle, Morrice, Nick A., Meek, Katheryn, Lees-Miller, Susan P.
Publicado 2014

Anemia, leukocytosis and thrombocytosis as prognostic factors in patients with cervical cancer treated with radical chemoradiotherapy: A retrospective cohort study

por Koulis, Theodora A., Kornaga, Elizabeth N., Banerjee, Robyn, Phan, Tien, Ghatage, Prafull, Magliocco, Anthony M., Lees-Miller, Susan P., Doll, Corinne M.
Publicado 2017

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP

por Deshpande, Rajashree A., Myler, Logan R., Soniat, Michael M., Makharashvili, Nodar, Lee, Linda, Lees-Miller, Susan P., Finkelstein, Ilya J., Paull, Tanya T.
Publicado 2020

Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued...

por Douglas, Pauline, Ye, Ruiqiong, Radhamani, Suraj, Cobban, Alexander, Jenkins, Nicole P., Bartlett, Edward, Roveredo, Jonathan, Kettenbach, Arminja N., Lees-Miller, Susan P.
Publicado 2020

XRCC4's interaction with XLF is required for coding (but not signal) end joining

por Roy, Sunetra, Andres, Sara N., Vergnes, Alexandra, Neal, Jessica A., Xu, Yao, Yu, Yaping, Lees-Miller, Susan P., Junop, Murray, Modesti, Mauro, Meek, Katheryn
Publicado 2012

ATM-Deficient Cancers Provide New Opportunities for Precision Oncology

por Jette, Nicholas R., Kumar, Mehul, Radhamani, Suraj, Arthur, Greydon, Goutam, Siddhartha, Yip, Steven, Kolinsky, Michael, Williams, Gareth J., Bose, Pinaki, Lees-Miller, Susan P.
Publicado 2020

Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease

por Walker, Simon R., Abdelsalam, Ramy, Ghosh, Sunita, Livingstone, Julie, Palanisamy, Nallasivam, Boutros, Paul C., Yip, Steven M., Lees-Miller, Susan P., Bismar, Tarek A.
Publicado 2021