sGC Stimulation Saves the Diabetic Heart: Red Blood Cells to the Rescue

por Papapetropoulos, Andreas, Lefer, David J.
Publicado 2023

Soluble urokinase plasminogen activator receptor: from biomarker to active participant in atherosclerosis and cardiovascular disease

por Goodchild, Traci T., Li, Zhen, Lefer, David J.
Publicado 2022

Reply: Tolerating Large Preclinical Models of HFpEF But Without the Intolerance?

por Sharp, Thomas E., Lefer, David J., Goodchild, Traci T.
Publicado 2021

Cardiometabolic Heart Failure and HFpEF: Still Chasing Unicorns

por Sharp, Thomas E., Lefer, David J., Houser, Steven R.
Publicado 2019

The Cardioprotective Actions of Hydrogen Sulfide in Acute Myocardial Infarction and Heart Failure

por Polhemus, David J., Calvert, John W., Butler, Javed, Lefer, David J.
Publicado 2014

Hydrogen Sulfide Levels and Nuclear Factor-Erythroid 2-Related Factor 2 (NRF2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI)

por Islam, Kazi N, Polhemus, David J, Donnarumma, Erminia, Brewster, Luke P, Lefer, David J
Publicado 2015

364 Beneficial Actions of SGLT2 Inhibition and H2S Therapy in Heart Failure with Preserved Ejection Fraction

por Doiron, Jake, Li, Zhen, Xia, Huijing, Lapenna, Kyle B., Allerton, Timothy D., Kapusta, Daniel R., Lefer, David J.
Publicado 2023

Nitrite Therapy Ameliorates Myocardial Dysfunction via H(2)S and Nuclear Factor‐Erythroid 2‐Related Factor 2 (Nrf2)‐Dependent Signaling in Chronic Heart Failure

por Donnarumma, Erminia, Bhushan, Shashi, Bradley, Jessica M., Otsuka, Hiroyuki, Donnelly, Erinn L., Lefer, David J., Islam, Kazi N.
Publicado 2016

Hydrogen Sulfide as a Potential Therapy for Heart Failure—Past, Present, and Future

por LaPenna, Kyle B., Polhemus, David J., Doiron, Jake E., Hidalgo, Hunter A., Li, Zhen, Lefer, David J.
Publicado 2021

Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice

por Chi, Yuling, Jasmin, Jean-Francois, Seki, Yoshinori, Lisanti, Michael P., Charron, Maureen J., Lefer, David J., Schuster, Victor L.
Publicado 2015

Combined Angiotensin Receptor–Neprilysin Inhibitors Improve Cardiac and Vascular Function Via Increased NO Bioavailability in Heart Failure

por Trivedi, Rishi K., Polhemus, David J., Li, Zhen, Yoo, Daniel, Koiwaya, Hiroshi, Scarborough, Amy, Goodchild, Traci T., Lefer, David J.
Publicado 2018

Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction

por Kar, Sumit, Shahshahan, Hamid R., Kambis, Tyler N., Yadav, Santosh K., Li, Zhen, Lefer, David J., Mishra, Paras K.
Publicado 2019

Exercise Training Promotes Cardiac Hydrogen Sulfide Biosynthesis and Mitigates Pyroptosis to Prevent High-Fat Diet-Induced Diabetic Cardiomyopathy

por Kar, Sumit, Shahshahan, Hamid R., Hackfort, Bryan T., Yadav, Santosh K., Yadav, Roopali, Kambis, Tyler N., Lefer, David J., Mishra, Paras K.
Publicado 2019

Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury

por Sharp, Thomas E., Gong, Zhenwei, Scarborough, Amy, Goetzman, Eric S., Ali, Murtuza J., Spaletra, Pablo, Lefer, David J., Muzumdar, Radhika H., Goodchild, Traci T.
Publicado 2020

Design, Synthesis, and Cardioprotective Effects of N-Mercapto-Based Hydrogen Sulfide Donors

por Zhao, Yu, Yang, Chuntao, Organ, Chelsea, Li, Zhen, Bhushan, Shashi, Otsuka, Hiro, Pacheco, Armando, Kang, Jianming, Aguilar, Hector C., Lefer, David J., Xian, Ming
Publicado 2015

Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling

por Polhemus, David J., Gao, Juan, Scarborough, Amy L., Trivedi, Rishi, McDonough, Kathleen H., Goodchild, Traci T., Smart, Frank, Kapusta, Daniel R., Lefer, David J.
Publicado 2016

Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure

por Organ, Chelsea L., Li, Zhen, Sharp, Thomas E., Polhemus, David J., Gupta, Nilaksh, Goodchild, Traci T., Tang, W. H. Wilson, Hazen, Stanley L., Lefer, David J.
Publicado 2020

Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure

por Li, Zhen, Organ, Chelsea L., Kang, Jianming, Polhemus, David J., Trivedi, Rishi K., Sharp, Thomas E., Jenkins, Jack S., Tao, Ya-xiong, Xian, Ming, Lefer, David J.
Publicado 2018

Endothelial Cell Cystathionine γ‐Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury

por Xia, Huijing, Li, Zhen, Sharp, Thomas E., Polhemus, David J., Carnal, Jean, Moles, Karl H., Tao, Ya‐Xiong, Elrod, John, Pfeilschifter, Josef, Beck, Karl‐Friedrich, Lefer, David J.
Publicado 2020

Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities

por Sharp, Thomas E., Scarborough, Amy L., Li, Zhen, Polhemus, David J., Hidalgo, Hunter A., Schumacher, Jeffery D., Matsuura, Timothy R., Jenkins, J. Stephen, Kelly, Daniel P., Goodchild, Traci T., Lefer, David J.
Publicado 2021