Understanding the pharmacokinetics of Coartem(®)

por Djimdé, Abdoulaye, Lefèvre, Gilbert
Publicado 2009

Effects of Renal Impairment on Steady-State Plasma Concentrations of Rivastigmine: A Population Pharmacokinetic Analysis of Capsule and Patch Formulations in Patients with Alzheime...

por Lefèvre, Gilbert, Callegari, Francesca, Gsteiger, Sandro, Xiong, Yuan
Publicado 2016

Differences in the pharmacokinetics of currently approved antimalarial drugs in uncomplicated malaria patients compared to healthy subjects

por Jain, Jay Prakash, Lakshminarayana, Suresh B, Lefèvre, Gilbert, Sivasubramanian, Rama, Blasco, Francesca, Sunkara, Gangadhar
Publicado 2012

Evaluation of two novel tablet formulations of artemether-lumefantrine (Coartem®) for bioequivalence in a randomized, open-label, two-period study

por Lefèvre, Gilbert, Bhad, Prafulla, Jain, Jay Prakash, Kalluri, Sampath, Cheng, Yi, Dave, Hardik, Stein, Daniel S
Publicado 2013

A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel spiroindolone KAE609, to assess the safety, tolerability and...

por Leong, Joel, Li, Ruobing, Jain, Jay Prakash, Lefèvre, Gilbert, Magnusson, Baldur, Diagana, Thierry, Pertel, Peter
Publicado 2014

A phase 1 evaluation of the pharmacokinetic/pharmacodynamic interaction of the antimalarial agents KAE609 and piperaquine (PPQ)

por Stein, Daniel S, Jain, Jay Prakash, Lickliter, Jason, Kangas, Michael, Machineni, Surendra, Griffin, Paul, Lefevre, Gilbert
Publicado 2014

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Antimalarial Spiroindolone KAE609 (Cipargamin) To Assess Its...

por Leong, F. Joel, Li, Ruobing, Jain, Jay Prakash, Lefèvre, Gilbert, Magnusson, Baldur, Diagana, Thierry T., Pertel, Peter
Publicado 2014

A Pooled Analysis of Three Randomized Phase I/IIa Clinical Trials Confirms Absence of a Clinically Relevant Effect on the QTc Interval by Umibecestat

por Vormfelde, Stefan Viktor, Pezous, Nicole, Lefèvre, Gilbert, Kolly, Carine, Neumann, Ulf, Jordaan, Pierre, Ufer, Mike, Legangneux, Eric
Publicado 2020

Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects

por Abdulla, Salim, Amuri, Baraka, Kabanywanyi, Abdunoor M, Ubben, David, Reynolds, Christine, Pascoe, Steve, Fitoussi, Serge, Yeh, Ching-Ming, Nuortti, Marja, Séchaud, Romain, Kaiser, Günther, Lefèvre, Gilbert
Publicado 2010

Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coart...

por Tiono, Alfred B, Tinto, Halidou, Alao, Maroufou J, Meremikwu, Martin, Tshefu, Antoinette, Ogutu, Bernhards, Ouedraogo, Alphonse, Lingani, Moussa, Cousin, Marc, Lefèvre, Gilbert, Jain, Jay Prakash, Duparc, Stephan, Hamed, Kamal
Publicado 2015

Similar efficacy and safety of artemether-lumefantrine (Coartem(®)) in African infants and children with uncomplicated falciparum malaria across different body weight ranges

por Bassat, Quique, González, Raquel, Machevo, Sónia, Nahum, Alain, Lyimo, John, Maiga, Hamma, Mårtensson, Andreas, Bashraheil, Mahfudh, Ouma, Peter, Ubben, David, Walter, Verena, Nwaiwu, Obiyo, Kipkeu, Chemtai, Lefèvre, Gilbert, Ogutu, Bernhards, Menéndez, Clara
Publicado 2011

Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis

por Kloprogge, Frank, Workman, Lesley, Borrmann, Steffen, Tékété, Mamadou, Lefèvre, Gilbert, Hamed, Kamal, Piola, Patrice, Ursing, Johan, Kofoed, Poul Erik, Mårtensson, Andreas, Ngasala, Billy, Björkman, Anders, Ashton, Michael, Friberg Hietala, Sofia, Aweeka, Francesca, Parikh, Sunil, Mwai, Leah, Davis, Timothy M. E., Karunajeewa, Harin, Salman, Sam, Checchi, Francesco, Fogg, Carole, Newton, Paul N., Mayxay, Mayfong, Deloron, Philippe, Faucher, Jean François, Nosten, François, Ashley, Elizabeth A., McGready, Rose, van Vugt, Michele, Proux, Stephane, Price, Ric N., Karbwang, Juntra, Ezzet, Farkad, Bakshi, Rajesh, Stepniewska, Kasia, White, Nicholas J., Guerin, Philippe J., Barnes, Karen I., Tarning, Joel
Publicado 2018