The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer: implications for the treatment of colorectal carcinogenesis

por Legge, Danny N, Chambers, Adam C, Parker, Christopher T, Timms, Penny, Collard, Tracey J, Williams, Ann C
Publicado 2020

In-silico and in-vitro morphometric analysis of intestinal organoids

por Montes-Olivas, Sandra, Legge, Danny, Lund, Abbie, Fletcher, Alexander G., Williams, Ann C., Marucci, Lucia, Homer, Martin
Publicado 2023

Aspirin and the metabolic hallmark of cancer: novel therapeutic opportunities for colorectal cancer

por Hoskin, Ashley J., Holt, Amy K., Legge, Danny N., Collard, Tracey J., Williams, Ann C., Vincent, Emma E.
Publicado 2023

BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells

por Legge, Danny N., Shephard, Alex P., Collard, Tracey J., Greenhough, Alexander, Chambers, Adam C., Clarkson, Richard W., Paraskeva, Christos, Williams, Ann C.
Publicado 2019

5-Aminosalicylic acid inhibits stem cell function in human adenoma-derived cells: implications for chemoprophylaxis in colorectal tumorigenesis

por Dixon, Steven William, Collard, Tracey Jane, Mortensson, Eleanor May Harrisdotter, Legge, Danny Nigel, Chambers, Adam Christian, Greenhough, Alexander, Creed, Tom Julian, Williams, Ann Caroline
Publicado 2021

Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization

por Gormley, Mark, Dudding, Tom, Thomas, Steven J, Tyrrell, Jessica, Ness, Andrew R, Pring, Miranda, Legge, Danny, Davey Smith, George, Richmond, Rebecca C, Vincent, Emma E, Bull, Caroline
Publicado 2023

The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor

por Legge, Danny, Li, Ling, Moriarty, Whei, Lee, David, Szemes, Marianna, Zahed, Asef, Panousopoulos, Leonidas, Chung, Wan Yun, Aghabi, Yara, Barratt, Jasmin, Williams, Richard, Pritchard‐Jones, Kathy, Malik, Karim T.A., Oltean, Sebastian, Brown, Keith W.
Publicado 2021

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

por Holt, Amy K., Najumudeen, Arafath K., Collard, Tracey J., Li, Hao, Millett, Laura M., Hoskin, Ashley J., Legge, Danny N., Mortensson, Eleanor M. H., Flanagan, Dustin J., Jones, Nicholas, Kollareddy, Madhu, Timms, Penny, Hitchings, Matthew D., Cronin, James, Sansom, Owen J., Williams, Ann C., Vincent, Emma E.
Publicado 2023

Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study

por Gormley, Mark, Yarmolinsky, James, Dudding, Tom, Burrows, Kimberley, Martin, Richard M., Thomas, Steven, Tyrrell, Jessica, Brennan, Paul, Pring, Miranda, Boccia, Stefania, Olshan, Andrew F., Diergaarde, Brenda, Hung, Rayjean J., Liu, Geoffrey, Legge, Danny, Tajara, Eloiza H., Severino, Patricia, Lacko, Martin, Ness, Andrew R., Davey Smith, George, Vincent, Emma E., Richmond, Rebecca C.
Publicado 2021

Identifying metabolic features of colorectal cancer liability using Mendelian randomization

por Bull, Caroline J., Hazelwood, Emma, Bell, Joshua A., Tan, Vanessa Y., Constantinescu, Andrei-Emil, Borges, Maria Carolina, Legge, Danny N., Burrows, Kimberly, Huyghe, Jeroen R., Brenner, Hermann, Castellví-Bel, Sergi, Chan, Andrew T, Kweon, Sun-Seog, Marchand, Loic Le, Li, Li, Cheng, Iona, Pai, Rish K., Figueiredo, Jane C., Murphy, Neil, Gunter, Marc J., Timpson, Nicholas J., Vincent, Emma E.
Publicado 2023