Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective

por Legge, Sophie E, Walters, James TR
Publicado 2019

Copy Number Variants Increasing Risk for Schizophrenia: Shared and Distinct Effects on Brain Morphometry and Cognitive Performance

por Caseras, Xavier, Legge, Sophie E., Bracher-Smith, Matthew, Anney, Richard, Owen, Michael J., Escott-Price, Valentina, Kirov, George
Publicado 2022

Effects of genomic copy number variants penetrant for schizophrenia on cortical thickness and surface area in healthy individuals: analysis of the UK Biobank

por Caseras, Xavier, Kirov, George, Kendall, Kimberley M., Rees, Elliott, Legge, Sophie E., Bracher-Smith, Matthew, Escott-Price, Valentina, Murphy, Kevin
Publicado 2021

Ultrarare Coding Variants and Cognitive Function in Schizophrenia

por Creeth, Hugo D. J., Rees, Elliott, Legge, Sophie E., Dennison, Charlotte A., Holmans, Peter, Walters, James T. R., O’Donovan, Michael C., Owen, Michael J.
Publicado 2022

Schizophrenia Polygenic Risk and Experiences of Childhood Adversity: A Systematic Review and Meta-analysis

por Woolway, Grace E, Smart, Sophie E, Lynham, Amy J, Lloyd, Jennifer L, Owen, Michael J, Jones, Ian R, Walters, James T R, Legge, Sophie E
Publicado 2022

Reasons for discontinuing clozapine: A cohort study of patients commencing treatment

por Legge, Sophie E., Hamshere, Marian, Hayes, Richard D., Downs, Johnny, O'Donovan, Michael C., Owen, Michael J., Walters, James T.R., MacCabe, James H.
Publicado 2016

Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type

por Dennison, Charlotte A, Legge, Sophie E, Hubbard, Leon, Lynham, Amy J, Zammit, Stanley, Holmans, Peter, Cardno, Alastair G, Owen, Michael J, O’Donovan, Michael C, Walters, James T R
Publicado 2021

Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count

por Lock, Siobhan K., Legge, Sophie E., Kappel, Djenifer B., Willcocks, Isabella R., Helthuis, Marinka, Jansen, John, Walters, James T. R., Owen, Michael J., O’Donovan, Michael C., Pardiñas, Antonio F.
Publicado 2023

Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia

por Willcocks, Isabella R., Legge, Sophie E., Nalmpanti, Mariana, Mazzeo, Lucy, King, Adrian, Jansen, John, Helthuis, Marinka, Owen, Michael J., O’Donovan, Michael C., Walters, James T. R., Pardiñas, Antonio F.
Publicado 2021

Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank

por Dennison, Charlotte A., Legge, Sophie E., Bracher-Smith, Matthew, Menzies, Georgina, Escott-Price, Valentina, Smith, Daniel J., Doherty, Aiden R., Owen, Michael J., O’Donovan, Michael C., Walters, James T. R.
Publicado 2021

Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort

por Grama, Steluta, Willcocks, Isabella, Hubert, John J., Pardiñas, Antonio F., Legge, Sophie E., Bracher-Smith, Matthew, Menzies, Georgina E., Hall, Lynsey S., Pocklington, Andrew J., Anney, Richard J. L., Bray, Nicholas J., Escott-Price, Valentina, Caseras, Xavier
Publicado 2020

Impact of schizophrenia genetic liability on the association between schizophrenia and physical illness: data-linkage study

por Kendall, Kimberley M., John, Ann, Lee, Sze Chim, Rees, Elliott, Pardiñas, Antonio F., Banos, Marcos Del Pozo, Owen, Michael J., O'Donovan, Michael C., Kirov, George, Lloyd, Keith, Jones, Ian, Legge, Sophie E., Walters, James T. R.
Publicado 2020

Analysis of copy number variations at 15 schizophrenia-associated loci

por Rees, Elliott, Walters, James T. R., Georgieva, Lyudmila, Isles, Anthony R., Chambert, Kimberly D., Richards, Alexander L., Mahoney-Davies, Gerwyn, Legge, Sophie E., Moran, Jennifer L., McCarroll, Steven A., O’Donovan, Michael C., Owen, Michael J., Kirov, George
Publicado 2014

Associations Between Schizophrenia Polygenic Liability, Symptom Dimensions, and Cognitive Ability in Schizophrenia

por Legge, Sophie E., Cardno, Alastair G., Allardyce, Judith, Dennison, Charlotte, Hubbard, Leon, Pardiñas, Antonio F., Richards, Alexander, Rees, Elliott, Di Florio, Arianna, Escott-Price, Valentina, Zammit, Stanley, Holmans, Peter, Owen, Michael J., O’Donovan, Michael C., Walters, James T. R.
Publicado 2021

The Duffy-null genotype and risk of infection

por Legge, Sophie E, Christensen, Rune H, Petersen, Liselotte, Pardiñas, Antonio F, Bracher-Smith, Matthew, Knapper, Steven, Bybjerg-Grauholm, Jonas, Baekvad-Hansen, Marie, Hougaard, David M, Werge, Thomas, Nordentoft, Merete, Mortensen, Preben Bo, Owen, Michael J, O’Donovan, Michael C, Benros, Michael E, Walters, James T R
Publicado 2020

Lack of Support for the Genes by Early Environment Interaction Hypothesis in the Pathogenesis of Schizophrenia

por Vassos, Evangelos, Kou, Jiaqi, Tosato, Sarah, Maxwell, Jessye, Dennison, Charlotte A, Legge, Sophie E, Walters, James T R, Owen, Michael J, O’Donovan, Michael C, Breen, Gerome, Lewis, Cathryn M, Sullivan, Patrick F, Hultman, Christina, Ruggeri, Mirella, Walshe, Muriel, Bramon, Elvira, Bergen, Sarah E, Murray, Robin M
Publicado 2021

Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits

por Legge, Sophie E., Jones, Hannah J., Kendall, Kimberley M., Pardiñas, Antonio F., Menzies, Georgina, Bracher-Smith, Matthew, Escott-Price, Valentina, Rees, Elliott, Davis, Katrina A. S., Hotopf, Matthew, Savage, Jeanne E., Posthuma, Danielle, Holmans, Peter, Kirov, George, Owen, Michael J., O’Donovan, Michael C., Zammit, Stanley, Walters, James T. R.
Publicado 2019

Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk var...

por Sanders, Bret, D’Andrea, Daniel, Collins, Mark O., Rees, Elliott, Steward, Tom G. J., Zhu, Ying, Chapman, Gareth, Legge, Sophie E., Pardiñas, Antonio F., Harwood, Adrian J., Gray, William P., O’Donovan, Michael C., Owen, Michael J., Errington, Adam C., Blake, Derek J., Whitcomb, Daniel J., Pocklington, Andrew J., Shin, Eunju
Publicado 2022

De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia

por Rees, Elliott, Han, Jun, Morgan, Joanne, Carrera, Noa, Escott-Price, Valentina, Pocklington, Andrew J., Duffield, Madeleine, Hall, Lynsey, Legge, Sophie E., Pardiñas, Antonio F., Richards, Alexander L., Roth, Julian, Lezheiko, Tatyana, Kondratyev, Nikolay, Kaleda, Vasilii, Golimbet, Vera, Parellada, Mara, González-Peñas, Javier, Arango, Celso, Gawlik, Micha, Kirov, George, Walters, James T. R., Holmans, Peter, O’Donovan, Michael C., Owen, Michael J.
Publicado 2020

HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry

por Konte, Bettina, Walters, James T. R., Rujescu, Dan, Legge, Sophie E., Pardiñas, Antonio F., Cohen, Dan, Pirmohamed, Munir, Tiihonen, Jari, Hartmann, Annette M., Bogers, Jan P., van der Weide, Jan, van der Weide, Karen, Putkonen, Anu, Repo-Tiihonen, Eila, Hallikainen, Tero, Silva, Ed, Ingimarsson, Oddur, Sigurdsson, Engilbert, Kennedy, James L., Sullivan, Patrick F., Rietschel, Marcella, Breen, Gerome, Stefansson, Hreinn, Stefansson, Kari, Collier, David A., O’Donovan, Michael C., Giegling, Ina
Publicado 2021