High-order combination effects and biological robustness

por Lehár, Joseph, Krueger, Andrew, Zimmermann, Grant, Borisy, Alexis
Publicado 2008

Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis

por Krueger, Andrew S., Munck, Christian, Dantas, Gautam, Church, George M., Galagan, James, Lehár, Joseph, Sommer, Morten O. A.
Publicado 2016

A Meta-Analysis Approach for Characterizing Pan-Cancer Mechanisms of Drug Sensitivity in Cell Lines

por Wang, Kendric, Shrestha, Raunak, Wyatt, Alexander W., Reddy, Anupama, Lehár, Joseph, Wang, Yuzhou, Lapuk, Anna, Collins, Colin C.
Publicado 2014

Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication

por Owens, Christopher M, Mawhinney, Christina, Grenier, Jill M, Altmeyer, Ralf, Lee, Margaret S, Borisy, Alexis A, Lehár, Joseph, Johansen, Lisa M
Publicado 2010

CANDI: an R package and Shiny app for annotating radiographs and evaluating computer-aided diagnosis

por Badgeley, Marcus A, Liu, Manway, Glicksberg, Benjamin S, Shervey, Mark, Zech, John, Shameer, Khader, Lehar, Joseph, Oermann, Eric K, McConnell, Michael V, Snyder, Thomas M, Dudley, Joel T
Publicado 2019

Recurrent, Robust and Scalable Patterns Underlie Human Approach and Avoidance

por Kim, Byoung Woo, Kennedy, David N., Lehár, Joseph, Lee, Myung Joo, Blood, Anne J., Lee, Sang, Perlis, Roy H., Smoller, Jordan W., Morris, Robert, Fava, Maurizio, Breiter, Hans C.
Publicado 2010

RAD001 Enhances the Potency of BEZ235 to Inhibit mTOR Signaling and Tumor Growth

por Nyfeler, Beat, Chen, Yan, Li, Xiaoyan, Pinzon-Ortiz, Maria, Wang, Zuncai, Reddy, Anupama, Pradhan, Elina, Das, Rita, Lehár, Joseph, Schlegel, Robert, Finan, Peter M., Cao, Z. Alexander, Murphy, Leon O., Huang, Alan
Publicado 2012

Synergistic drug combinations improve therapeutic selectivity

por Lehàr, Joseph, Krueger, Andrew S., Avery, William, Heilbut, Adrian M., Johansen, Lisa M., Price, E. Roydon, Rickles, Richard J., Short, Glenn F., Staunton, Jane E., Jin, Xiaowei, Lee, Margaret S., Zimmermann, Grant R., Borisy, Alexis A.
Publicado 2009

Knocking out multi-gene redundancies via cycles of sexual assortment and fluorescence selection

por Suzuki, Yo, St. Onge, Robert P., Mani, Ramamurthy, King, Oliver D., Heilbut, Adrian, Labunskyy, Vyacheslav M., Chen, Weidong, Pham, Linda, Zhang, Lan V., Tong, Amy H. Y., Nislow, Corey, Giaever, Guri, Gladyshev, Vadim N., Vidal, Marc, Schow, Peter, Lehár, Joseph, Roth, Frederick P.
Publicado 2011

Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages

por Reddy, Anupama, Growney, Joseph D., Wilson, Nick S., Emery, Caroline M., Johnson, Jennifer A., Ward, Rebecca, Monaco, Kelli A., Korn, Joshua, Monahan, John E., Stump, Mark D., Mapa, Felipa A., Wilson, Christopher J., Steiger, Janine, Ledell, Jebediah, Rickles, Richard J., Myer, Vic E., Ettenberg, Seth A., Schlegel, Robert, Sellers, William R., Huet, Heather A., Lehár, Joseph
Publicado 2015

Correction: Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages

por Reddy, Anupama, Growney, Joseph D., Wilson, Nick S., Emery, Caroline M., Johnson, Jennifer A., Ward, Rebecca, Monaco, Kelli A., Korn, Joshua, Monahan, John E., Stump, Mark D., Mapa, Felipa A., Wilson, Christopher J., Steiger, Janine, Ledell, Jebediah, Rickles, Richard J., Myer, Vic E., Ettenberg, Seth A., Schlegel, Robert, Sellers, William R., Huet, Heather A., Lehár, Joseph
Publicado 2016

Quantifying neurologic disease using biosensor measurements in-clinic and in free-living settings in multiple sclerosis

por Chitnis, Tanuja, Glanz, Bonnie I., Gonzalez, Cindy, Healy, Brian C., Saraceno, Taylor J., Sattarnezhad, Neda, Diaz-Cruz, Camilo, Polgar-Turcsanyi, Mariann, Tummala, Subhash, Bakshi, Rohit, Bajaj, Vikram S., Ben-Shimol, David, Bikhchandani, Nikhil, Blocker, Alexander W., Burkart, Joshua, Cendrillon, Raphael, Cusack, Michael P., Demiralp, Emre, Jooste, Sarel Kobus, Kharbouch, Alaa, Lee, Amy A., Lehár, Joseph, Liu, Manway, Mahadevan, Swaminathan, Murphy, Mark, Norton, Linda C., Parlikar, Tushar A., Pathak, Anupam, Shoeb, Ali, Soderberg, Erin, Stephens, Philip, Stoertz, Aaron H., Thng, Florence, Tumkur, Kashyap, Wang, Hongsheng, Rhodes, Jane, Rudick, Richard A., Ransohoff, Richard M., Phillips, Glenn A., Bruzik, Effie, Marks, William J., Weiner, Howard L., Snyder, Thomas M.
Publicado 2019

The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity

por Barretina, Jordi, Caponigro, Giordano, Stransky, Nicolas, Venkatesan, Kavitha, Margolin, Adam A., Kim, Sungjoon, Wilson, Christopher J., Lehár, Joseph, Kryukov, Gregory V., Sonkin, Dmitriy, Reddy, Anupama, Liu, Manway, Murray, Lauren, Berger, Michael F., Monahan, John E., Morais, Paula, Meltzer, Jodi, Korejwa, Adam, Jané-Valbuena, Judit, Mapa, Felipa A., Thibault, Joseph, Bric-Furlong, Eva, Raman, Pichai, Shipway, Aaron, Engels, Ingo H., Cheng, Jill, Yu, Guoying K., Yu, Jianjun, Aspesi, Peter, de Silva, Melanie, Jagtap, Kalpana, Jones, Michael D., Wang, Li, Hatton, Charles, Palescandolo, Emanuele, Gupta, Supriya, Mahan, Scott, Sougnez, Carrie, Onofrio, Robert C., Liefeld, Ted, MacConaill, Laura, Winckler, Wendy, Reich, Michael, Li, Nanxin, Mesirov, Jill P., Gabriel, Stacey B., Getz, Gad, Ardlie, Kristin, Chan, Vivien, Myer, Vic E., Weber, Barbara L., Porter, Jeff, Warmuth, Markus, Finan, Peter, Harris, Jennifer L., Meyerson, Matthew, Golub, Todd R., Morrissey, Michael P., Sellers, William R., Schlegel, Robert, Garraway, Levi A.
Publicado 2012