Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

por Bacic, Luka, Gaullier, Guillaume, Sabantsev, Anton, Lehmann, Laura C, Brackmann, Klaus, Dimakou, Despoina, Halic, Mario, Hewitt, Graeme, Boulton, Simon J, Deindl, Sebastian
Publicado 2021

New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites

por Ballet, Caroline, Correia, Mário S. P., Conway, Louis P., Locher, Theresa L., Lehmann, Laura C., Garg, Neeraj, Vujasinovic, Miroslav, Deindl, Sebastian, Löhr, J.-Matthias, Globisch, Daniel
Publicado 2018

Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch

por Lehmann, Laura C., Bacic, Luka, Hewitt, Graeme, Brackmann, Klaus, Sabantsev, Anton, Gaullier, Guillaume, Pytharopoulou, Sofia, Degliesposti, Gianluca, Okkenhaug, Hanneke, Tan, Song, Costa, Alessandro, Skehel, J. Mark, Boulton, Simon J., Deindl, Sebastian
Publicado 2020

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

por Lehmann, Laura C., Hewitt, Graeme, Aibara, Shintaro, Leitner, Alexander, Marklund, Emil, Maslen, Sarah L., Maturi, Varun, Chen, Yang, van der Spoel, David, Skehel, J. Mark, Moustakas, Aristidis, Boulton, Simon J., Deindl, Sebastian
Publicado 2017

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

por Hewitt, Graeme, Borel, Valerie, Segura-Bayona, Sandra, Takaki, Tohru, Ruis, Phil, Bellelli, Roberto, Lehmann, Laura C., Sommerova, Lucia, Vancevska, Aleksandra, Tomas-Loba, Antonia, Zhu, Kang, Cooper, Christopher, Fugger, Kasper, Patel, Harshil, Goldstone, Robert, Schneider-Luftman, Deborah, Herbert, Ellie, Stamp, Gordon, Brough, Rachel, Pettitt, Stephen, Lord, Christopher J., West, Stephen C., Ahel, Ivan, Ahel, Dragana, Chapman, J. Ross, Deindl, Sebastian, Boulton, Simon J.
Publicado 2021