A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug–Drug–Gene Interaction Predictions

por Türk, Denise, Hanke, Nina, Lehr, Thorsten
Publicado 2020

A Quantitative Systems Pharmacology Kidney Model of Diabetes Associated Renal Hyperfiltration and the Effects of SGLT Inhibitors

por Balazki, Pavel, Schaller, Stephan, Eissing, Thomas, Lehr, Thorsten
Publicado 2018

A Physiologically‐Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP‐1 and GIP and the DPP4 Inhibitor Sitagliptin

por Balazki, Pavel, Schaller, Stephan, Eissing, Thomas, Lehr, Thorsten
Publicado 2020

Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis

por Fuhr, Laura Maria, Hanke, Nina, Meibohm, Bernd, Lehr, Thorsten
Publicado 2020

Translational PBPK Modeling of the Protein Therapeutic and CD95L Inhibitor Asunercept to Develop Dose Recommendations for Its First Use in Pediatric Glioblastoma Patients

por Hanke, Nina, Kunz, Claudia, Thiemann, Meinolf, Fricke, Harald, Lehr, Thorsten
Publicado 2019

Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups

por Rüdesheim, Simeon, Selzer, Dominik, Fuhr, Uwe, Schwab, Matthias, Lehr, Thorsten
Publicado 2022

Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies

por Lehr, Thorsten, Yuan, Jing, Zeumer, Dirk, Jayadev, Supriya, Ritchie, Marylyn D
Publicado 2011

Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling

por Wojtyniak, Jan‐Georg, Britz, Hannah, Selzer, Dominik, Schwab, Matthias, Lehr, Thorsten
Publicado 2020

Neovascular Age‐Related Macular Degeneration: A Visual Acuity Model of Natural Disease Progression and Ranibizumab Treatment Effect

por Mulyukov, Zufar, Weber, Sebastian, Pigeolet, Etienne, Clemens, Andreas, Lehr, Thorsten, Racine, Amy
Publicado 2018

Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

por Fuhr, Laura Maria, Marok, Fatima Zahra, Hanke, Nina, Selzer, Dominik, Lehr, Thorsten
Publicado 2021

Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network

por Marok, Fatima Zahra, Fuhr, Laura Maria, Hanke, Nina, Selzer, Dominik, Lehr, Thorsten
Publicado 2021

In Vitro–In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier

por Kovar, Lukas, Wien, Lena, Selzer, Dominik, Kohl, Yvonne, Bals, Robert, Lehr, Thorsten
Publicado 2022

Pharmacometric Characterization of Dabigatran Hemodialysis

por Liesenfeld, Karl-Heinz, Staab, Alexander, Härtter, Sebastian, Formella, Stephan, Clemens, Andreas, Lehr, Thorsten
Publicado 2013

PBPK Models for CYP3A4 and P‐gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin

por Hanke, Nina, Frechen, Sebastian, Moj, Daniel, Britz, Hannah, Eissing, Thomas, Wendl, Thomas, Lehr, Thorsten
Publicado 2018

Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates

por Kovar, Lukas, Schräpel, Christina, Selzer, Dominik, Kohl, Yvonne, Bals, Robert, Schwab, Matthias, Lehr, Thorsten
Publicado 2020

Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug–Drug–Gene Interaction Prediction...

por Loer, Helena Leonie Hanae, Türk, Denise, Gómez-Mantilla, José David, Selzer, Dominik, Lehr, Thorsten
Publicado 2022

A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug–Drug Interaction Modeling

por Fuhr, Laura Maria, Marok, Fatima Zahra, Mees, Maximilian, Mahfoud, Felix, Selzer, Dominik, Lehr, Thorsten
Publicado 2022

Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone

por Rüdesheim, Simeon, Selzer, Dominik, Mürdter, Thomas, Igel, Svitlana, Kerb, Reinhold, Schwab, Matthias, Lehr, Thorsten
Publicado 2022

Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions

por Rüdesheim, Simeon, Wojtyniak, Jan-Georg, Selzer, Dominik, Hanke, Nina, Mahfoud, Felix, Schwab, Matthias, Lehr, Thorsten
Publicado 2020

Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pio...

por Türk, Denise, Hanke, Nina, Wolf, Sarah, Frechen, Sebastian, Eissing, Thomas, Wendl, Thomas, Schwab, Matthias, Lehr, Thorsten
Publicado 2019