Progressive Volume Loss and White Matter Degeneration in Cstb-Deficient Mice: A Diffusion Tensor and Longitudinal Volumetry MRI Study

por Manninen, Otto, Laitinen, Teemu, Lehtimäki, Kimmo K., Tegelberg, Saara, Lehesjoki, Anna-Elina, Gröhn, Olli, Kopra, Outi
Publicado 2014

An in vivo accelerated developmental myelination model for testing promyelinating therapeutics

por Lariosa-Willingham, Karen, Leonoudakis, Dmitri, Bragge, Timo, Tolppanen, Laura, Nurmi, Antti, Flanagan, Megan, Gibson, Janelle, Wilson, David, Stratton, Jennifer, Lehtimäki, Kimmo K., Miszczuk, Diana
Publicado 2022

The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain

por Datson, Nicole A., González-Barriga, Anchel, Kourkouta, Eleni, Weij, Rudie, van de Giessen, Jeroen, Mulders, Susan, Kontkanen, Outi, Heikkinen, Taneli, Lehtimäki, Kimmo, van Deutekom, Judith C. T.
Publicado 2017

Using a State-of-the-Art Toolbox to Evaluate Molecular and Functional Readouts of Antisense Oligonucleotide-Induced Exon Skipping in mdx Mice

por Datson, Nicole A., Bijl, Suzanne, Janson, Anneke, Testerink, Janwillem, van den Eijnde, Rani, Weij, Rudie, Puoliväli, Jukka, Lehtimäki, Kimmo, Bragge, Timo, Ahtoniemi, Toni, van Deutekom, Judith C.
Publicado 2020

mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models

por Colton, Carol A., Wilson, Joan G., Everhart, Angela, Wilcock, Donna M., Puoliväli, Jukka, Heikkinen, Taneli, Oksman, Juho, Jääskeläinen, Olli, Lehtimäki, Kimmo, Laitinen, Teemu, Vartiainen, Nina, Vitek, Michael P.
Publicado 2014

Improved synthesis of [(18)F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors

por Huhtala, Tuulia, Poutiainen, Pekka, Rytkönen, Jussi, Lehtimäki, Kimmo, Parkkari, Teija, Kasanen, Iiris, Airaksinen, Anu J., Koivula, Teija, Sweeney, Patrick, Kontkanen, Outi, Wityak, John, Dominiquez, Celia, Park, Larry C.
Publicado 2019

Hip region muscular dystrophy and emergence of motor deficits in dysferlin‐deficient Bla/J mice

por Nagy, Nadia, Nonneman, Randal J., Llanga, Telmo, Dial, Catherine F., Riddick, Natallia V., Hampton, Tom, Moy, Sheryl S., Lehtimäki, Kimmo K., Ahtoniemi, Toni, Puoliväli, Jukka, Windish, Hillarie, Albrecht, Douglas, Richard, Isabelle, Hirsch, Matthew L.
Publicado 2017

The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington’s Disease

por Beaumont, Vahri, Park, Larry, Rassoulpour, Arash, Dijkman, Ulrike, Heikkinen, Taneli, Lehtimaki, Kimmo, Kontkanen, Outi, Al Nackkash, Rand, Bates, Gillian P., Gleyzes, Melanie, Steidl, Esther, Ramboz, Sylvie, Murphy, Carol, Beconi, Maria G., Dominguez, Celia, Munoz-Sanjuan, Ignacio
Publicado 2014

Vertigoheel promotes rodent cognitive performance in multiple memory tests

por Ott, Kerstin, Heikkinen, Taneli, Lehtimäki, Kimmo K., Paldanius, Kaisa, Puoliväli, Jukka, Pussinen, Raimo, Andriambeloson, Emile, Huyard, Bertrand, Wagner, Stéphanie, Schnack, Cathrin, Wahler, Anke, von Einem, Bjoern, von Arnim, Christine A. F., Burmeister, Yvonne, Weyer, Kathrin, Seilheimer, Bernd
Publicado 2023

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

por Heikkinen, Taneli, Lehtimäki, Kimmo, Vartiainen, Nina, Puoliväli, Jukka, Hendricks, Susan J., Glaser, Jack R., Bradaia, Amyaouch, Wadel, Kristian, Touller, Chrystelle, Kontkanen, Outi, Yrjänheikki, Juha M., Buisson, Bruno, Howland, David, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Park, Larry C.
Publicado 2012

Systemic Delivery of Dysferlin Overlap Vectors Provides Long-Term Gene Expression and Functional Improvement for Dysferlinopathy

por Potter, Rachael A., Griffin, Danielle A., Sondergaard, Patricia C., Johnson, Ryan W., Pozsgai, Eric R., Heller, Kristin N., Peterson, Ellyn L., Lehtimäki, Kimmo K., Windish, Hillarie P., Mittal, Plavi J., Albrecht, Douglas E., Mendell, Jerry R., Rodino-Klapac, Louise R.
Publicado 2018

Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington's Disease

por Menalled, Liliana B., Kudwa, Andrea E., Oakeshott, Steve, Farrar, Andrew, Paterson, Neil, Filippov, Igor, Miller, Sam, Kwan, Mei, Olsen, Michael, Beltran, Jose, Torello, Justin, Fitzpatrick, Jon, Mushlin, Richard, Cox, Kimberly, McConnell, Kristi, Mazzella, Matthew, He, Dansha, Osborne, Georgina F., Al-Nackkash, Rand, Bates, Gill P., Tuunanen, Pasi, Lehtimaki, Kimmo, Brunner, Dani, Ghavami, Afshin, Ramboz, Sylvie, Park, Larry, Macdonald, Douglas, Munoz-Sanjuan, Ignacio, Howland, David
Publicado 2014

Inaugural Charles River World Congress on Animal Models in Drug Discovery and Development

por Berzofsky, Jay A., Koch, Lauren Gerard, Britton, Steven L., Chen, Shaochen, Zhu, Wei, Ma, Xuanyi, Comuzzie, Anthony G., Devy-Dimanche, Laetitia, Feaver, Ryan, Grimm, Jan, Hock, Christoph, Nitsch, Roger M., Hoying, James B., Lusis, Aldons J., Marincola, Francesco, Samayoa, Josue, Turan, Tolga, Pearce, David A., Nurmi, Antti, Huhtala, Tuulia, Shatillo, Artem, Puoliväli, Jukka, Heikkinen, Taneli, Bragge, Timo, Lehtimäki, Kimmo, Sanyal, Arun J., Strange, Kevin, Taylor, D. Lansing, Miedel, Mark, Jia, Shanhang, Soto-Guterriez, Alex, Stern, Andrew, Gough, Albert
Publicado 2017