Transfection of Infectious RNA and DNA/RNA Layered Vectors of Semliki Forest Virus by the Cell-Penetrating Peptide Based Reagent PepFect6

por Pärn, Kalle, Viru, Liane, Lehto, Taavi, Oskolkov, Nikita, Langel, Ülo, Merits, Andres
Publicado 2013

Smad-binding decoy reduces extracellular matrix expression in human hypertrophic scar fibroblasts

por Fan, Chen, El Andaloussi, Samir, Lehto, Taavi, Kong, Kiat Whye, Seow, Yiqi
Publicado 2020

Novel viral vectors utilizing intron splice-switching to activate genome rescue, expression and replication in targeted cells

por Viru, Liane, Heller, Gregory, Lehto, Taavi, Pärn, Kalle, El Andaloussi, Samir, Langel, Ülo, Merits, Andres
Publicado 2011

Cellular trafficking determines the exon skipping activity of Pip6a-PMO in mdx skeletal and cardiac muscle cells

por Lehto, Taavi, Castillo Alvarez, Alejandra, Gauck, Sarah, Gait, Michael J., Coursindel, Thibault, Wood, Matthew J. A., Lebleu, Bernard, Boisguerin, Prisca
Publicado 2014

Efficient Peptide-Mediated In Vitro Delivery of Cas9 RNP

por Gustafsson, Oskar, Rädler, Julia, Roudi, Samantha, Lehto, Tõnis, Hällbrink, Mattias, Lehto, Taavi, Gupta, Dhanu, Andaloussi, Samir EL, Nordin, Joel Z.
Publicado 2021

Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions

por Ezzat, Kariem, Zaghloul, Eman M., EL Andaloussi, Samir, Lehto, Taavi, El-Sayed, Ramy, Magdy, Tarek, Smith, C.I. Edvard, Langel, Ülo
Publicado 2012

Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations

por Saher, Osama, Lehto, Taavi, Gissberg, Olof, Gupta, Dhanu, Gustafsson, Oskar, Andaloussi, Samir EL, Darbre, Tamis, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula
Publicado 2019

Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles

por Bost, Jeremy P., Barriga, Hanna, Holme, Margaret N., Gallud, Audrey, Maugeri, Marco, Gupta, Dhanu, Lehto, Taavi, Valadi, Hadi, Esbjörner, Elin K., Stevens, Molly M., El-Andaloussi, Samir
Publicado 2021

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

por Zheng, Wenyi, Rädler, Julia, Sork, Helena, Niu, Zheyu, Roudi, Samantha, Bost, Jeremy P., Görgens, André, Zhao, Ying, Mamand, Doste R., Liang, Xiuming, Wiklander, Oscar P. B., Lehto, Taavi, Gupta, Dhanu, Nordin, Joel Z., EL Andaloussi, Samir
Publicado 2023

Fine Tuning of Phosphorothioate Inclusion in 2′-O-Methyl Oligonucleotides Contributes to Specific Cell Targeting for Splice-Switching Modulation

por Aoki, Yoshitsugu, Rocha, Cristina S. J., Lehto, Taavi, Miyatake, Shouta, Johansson, Henrik, Hashimoto, Yasumasa, Nordin, Joel Z., Mager, Imre, Aoki, Misako, Graham, McClorey, Sathyaprakash, Chaitra, Roberts, Thomas C., Wood, Matthew J. A., Behlke, Mark A., Andaloussi, Samir El
Publicado 2021

Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo

por Bazaz, Safa, Lehto, Tõnis, Tops, Rahel, Gissberg, Olof, Gupta, Dhanu, Bestas, Burcu, Bost, Jeremy, Wiklander, Oscar P. B., Sork, Helena, Zaghloul, Eman M., Mamand, Doste R., Hällbrink, Mattias, Sillard, Rannar, Saher, Osama, Ezzat, Kariem, Smith, C. I. Edvard, Andaloussi, Samir EL, Lehto, Taavi
Publicado 2021

Delivery is key: lessons learnt from developing splice‐switching antisense therapies

por Godfrey, Caroline, Desviat, Lourdes R, Smedsrød, Bård, Piétri‐Rouxel, France, Denti, Michela A, Disterer, Petra, Lorain, Stéphanie, Nogales‐Gadea, Gisela, Sardone, Valentina, Anwar, Rayan, EL Andaloussi, Samir, Lehto, Taavi, Khoo, Bernard, Brolin, Camilla, van Roon‐Mom, Willeke MC, Goyenvalle, Aurélie, Aartsma‐Rus, Annemieke, Arechavala‐Gomeza, Virginia
Publicado 2017

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

por Ezzat, Kariem, EL Andaloussi, Samir, Zaghloul, Eman M., Lehto, Taavi, Lindberg, Staffan, Moreno, Pedro M. D., Viola, Joana R., Magdy, Tarek, Abdo, Rania, Guterstam, Peter, Sillard, Rannar, Hammond, Suzan M., Wood, Matthew J. A., Arzumanov, Andrey A., Gait, Michael J., Smith, C. I. Edvard, Hällbrink, Mattias, Langel, Ülo
Publicado 2011

Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides

por Bost, Jeremy P., Ojansivu, Miina, Munson, Michael J., Wesén, Emelie, Gallud, Audrey, Gupta, Dhanu, Gustafsson, Oskar, Saher, Osama, Rädler, Julia, Higgins, Stuart G., Lehto, Taavi, Holme, Margaret N., Dahlén, Anders, Engkvist, Ola, Strömstedt, Per-Erik, Andersson, Shalini, Edvard Smith, C. I., Stevens, Molly M., Esbjörner, Elin K., Collén, Anna, El Andaloussi, Samir
Publicado 2022

Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

por Hammond, Suzan M, Aartsma‐Rus, Annemieke, Alves, Sandra, Borgos, Sven E, Buijsen, Ronald A M, Collin, Rob W J, Covello, Giuseppina, Denti, Michela A, Desviat, Lourdes R, Echevarría, Lucía, Foged, Camilla, Gaina, Gisela, Garanto, Alejandro, Goyenvalle, Aurelie T, Guzowska, Magdalena, Holodnuka, Irina, Jones, David R, Krause, Sabine, Lehto, Taavi, Montolio, Marisol, Van Roon‐Mom, Willeke, Arechavala‐Gomeza, Virginia
Publicado 2021

mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells

por Bevers, Sanne, Kooijmans, Sander A.A., Van de Velde, Elien, Evers, Martijn J.W., Seghers, Sofie, Gitz-Francois, Jerney J.J.M., van Kronenburg, Nicky C.H., Fens, Marcel H.A.M., Mastrobattista, Enrico, Hassler, Lucie, Sork, Helena, Lehto, Taavi, Ahmed, Kariem E., El Andaloussi, Samir, Fiedler, Katja, Breckpot, Karine, Maes, Michael, Van Hoorick, Diane, Bastogne, Thierry, Schiffelers, Raymond M., De Koker, Stefaan
Publicado 2022

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

por EL Andaloussi, Samir, Lehto, Taavi, Mäger, Imre, Rosenthal-Aizman, Katri, Oprea, Iulian I., Simonson, Oscar E., Sork, Helena, Ezzat, Kariem, Copolovici, Dana M., Kurrikoff, Kaido, Viola, Joana R., Zaghloul, Eman M., Sillard, Rannar, Johansson, Henrik J., Said Hassane, Fatouma, Guterstam, Peter, Suhorutšenko, Julia, Moreno, Pedro M. D., Oskolkov, Nikita, Hälldin, Jonas, Tedebark, Ulf, Metspalu, Andres, Lebleu, Bernard, Lehtiö, Janne, Smith, C. I. Edvard, Langel, Ülo
Publicado 2011