Neural Network Differential Equations For Ion Channel Modelling

por Lei, Chon Lok, Mirams, Gary R.
Publicado 2021

Integration of deep learning with Ramachandran plot molecular dynamics simulation for genetic variant classification

por Tam, Benjamin, Qin, Zixin, Zhao, Bojin, Wang, San Ming, Lei, Chon Lok
Publicado 2023

Calibration of ionic and cellular cardiac electrophysiology models

por Whittaker, Dominic G., Clerx, Michael, Lei, Chon Lok, Christini, David J., Mirams, Gary R.
Publicado 2020

A hackable, multi-functional, and modular extrusion 3D printer for soft materials

por Lei, Iek Man, Sheng, Yaqi, Lei, Chon Lok, Leow, Cillian, Huang, Yan Yan Shery
Publicado 2022

Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System

por Lei, Chon Lok, Clerx, Michael, Gavaghan, David J., Polonchuk, Liudmila, Mirams, Gary R., Wang, Ken
Publicado 2019

Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment

por Farm, Hui Jia, Clerx, Michael, Cooper, Fergus, Polonchuk, Liudmila, Wang, Ken, Gavaghan, David J., Lei, Chon Lok
Publicado 2023

What we learned from lifting COVID-19 restrictions in Macao in December 2022

por LEI, Chon Lok, NG, Hoi Man, QIN, Guihui, YEUNG, Cheung Kwan, LEI, Chon Leng, XU, Ren-He
Publicado 2023

Beta-cell hubs maintain Ca(2+) oscillations in human and mouse islet simulations

por Lei, Chon-Lok, Kellard, Joely A., Hara, Manami, Johnson, James D., Rodriguez, Blanca, Briant, Linford J.B.
Publicado 2018

Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

por Lei, Chon Lok, Clerx, Michael, Whittaker, Dominic G., Gavaghan, David J., de Boer, Teun P., Mirams, Gary R.
Publicado 2020

Autocorrelated measurement processes and inference for ordinary differential equation models of biological systems

por Lambert, Ben, Lei, Chon Lok, Robinson, Martin, Clerx, Michael, Creswell, Richard, Ghosh, Sanmitra, Tavener, Simon, Gavaghan, David J.
Publicado 2023

Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics

por Shuttleworth, Joseph G., Lei, Chon Lok, Whittaker, Dominic G., Windley, Monique J., Hill, Adam P., Preston, Simon P., Mirams, Gary R.
Publicado 2023

Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings

por Clark, Alexander P, Clerx, Michael, Wei, Siyu, Lei, Chon Lok, de Boer, Teun P, Mirams, Gary R, Christini, David J, Krogh-Madsen, Trine
Publicado 2023

Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence

por Lei, Chon Lok, Clerx, Michael, Beattie, Kylie A., Melgari, Dario, Hancox, Jules C., Gavaghan, David J., Polonchuk, Liudmila, Wang, Ken, Mirams, Gary R.
Publicado 2019

A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer

por Lei, Chon Lok, Fabbri, Alan, Whittaker, Dominic G., Clerx, Michael, Windley, Monique J., Hill, Adam P., Mirams, Gary R., de Boer, Teun P.
Publicado 2021

Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology

por Lei, Chon Lok, Wang, Ken, Clerx, Michael, Johnstone, Ross H., Hortigon-Vinagre, Maria P., Zamora, Victor, Allan, Andrew, Smith, Godfrey L., Gavaghan, David J., Mirams, Gary R., Polonchuk, Liudmila
Publicado 2017

Heterologous vaccination with inactivated vaccine and mRNA vaccine augments antibodies against both spike and nucleocapsid proteins of SARS-CoV-2: a local study in Macao

por Ng, Hoi Man, Lei, Chon Lok, Fu, Siyi, Li, Enqin, Leong, Sek In, Nip, Chu Iong, Choi, Nga Man, Lai, Kai Seng, Tang, Xi Jun, Lei, Chon Leng, Xu, Ren-He
Publicado 2023

3D printed biomimetic cochleae and machine learning co-modelling provides clinical informatics for cochlear implant patients

por Lei, Iek Man, Jiang, Chen, Lei, Chon Lok, de Rijk, Simone Rosalie, Tam, Yu Chuen, Swords, Chloe, Sutcliffe, Michael P. F., Malliaras, George G., Bance, Manohar, Huang, Yan Yan Shery
Publicado 2021

Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells

por Meng, Ya, Song, Chengcheng, Ren, Zhili, Li, Xiaohong, Yang, Xiangyu, Ai, Nana, Yang, Yang, Wang, Dongjin, Zhan, Meixiao, Wang, Jiaxian, LEI, Chon Lok, Liu, Weiwei, Ge, Wei, Lu, Ligong, Chen, Guokai
Publicado 2021

Learning transmission dynamics modelling of COVID-19 using comomodels

por van der Vegt, Solveig A., Dai, Liangti, Bouros, Ioana, Farm, Hui Jia, Creswell, Richard, Dimdore-Miles, Oscar, Cazimoglu, Idil, Bajaj, Sumali, Hopkins, Lyle, Seiferth, David, Cooper, Fergus, Lei, Chon Lok, Gavaghan, David, Lambert, Ben
Publicado 2022

Considering discrepancy when calibrating a mechanistic electrophysiology model

por Lei, Chon Lok, Ghosh, Sanmitra, Whittaker, Dominic G., Aboelkassem, Yasser, Beattie, Kylie A., Cantwell, Chris D., Delhaas, Tammo, Houston, Charles, Novaes, Gustavo Montes, Panfilov, Alexander V., Pathmanathan, Pras, Riabiz, Marina, dos Santos, Rodrigo Weber, Walmsley, John, Worden, Keith, Mirams, Gary R., Wilkinson, Richard D.
Publicado 2020