Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors

por Zhang, Xin, Sun, Meng-Yang, Zhang, Xue, Guo, Chang-Run, Lei, Yun-Tao, Wang, Wen-Hui, Fan, Ying-Zhe, Cao, Peng, Li, Chang-Zhu, Wang, Rui, Li, Xing-Hua, Yu, Ye, Yang, Xiao-Na
Publicado 2022

Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells

por Yu, Peng-Cheng, Liu, Di, Han, Zeng-Xiang, Liang, Fang, Hao, Cui-Yun, Lei, Yun-Tao, Guo, Chang-Run, Wang, Wen-Hui, Li, Xing-Hua, Yang, Xiao-Na, Li, Chang-Zhu, Yu, Ye, Fan, Ying-Zhe
Publicado 2022

P2X3-selective mechanism of Gefapixant, a drug candidate for the treatment of refractory chronic cough

por Cui, Wen-Wen, Wang, Si-Yu, Zhang, Yu-Qing, Wang, Yao, Fan, Ying-Zhe, Guo, Chang-Run, Li, Xing-Hua, Lei, Yun-Tao, Wang, Wen-Hui, Yang, Xiao-Na, Hattori, Motoyuki, Li, Chang-Zhu, Wang, Jin, Yu, Ye
Publicado 2022

The long β2,3-sheets encoded by redundant sequences play an integral role in the channel function of P2X7 receptors

por Ma, Xue-Fei, Wang, Ting-Ting, Wang, Wen-Hui, Guan, Li, Guo, Chang-Run, Li, Xing-Hua, Lei, Yun-Tao, Fan, Ying-Zhe, Yang, Xiao-Na, Hattori, Motoyuki, Nureki, Osamu, Zhu, Michael X., Yu, Ye, Tian, Yun, Wang, Jin
Publicado 2022

GSK1702934A and M085 directly activate TRPC6 via a mechanism of stimulating the extracellular cavity formed by the pore helix and transmembrane helix S6

por Yang, Pei-Lin, Li, Xing-Hua, Wang, Jin, Ma, Xue-Fei, Zhou, Bo-Ying, Jiao, Yuan-Feng, Wang, Wen-Hui, Cao, Peng, Zhu, Michael Xi, Li, Pei-Wang, Xiao, Zhi-Hong, Li, Chang-Zhu, Guo, Chang-Run, Lei, Yun-Tao, Yu, Ye
Publicado 2021

Chronic cough relief by allosteric modulation of P2X3 without taste disturbance

por Guo, Chang-Run, Zhang, Zhong-Zhe, Zhou, Xing, Sun, Meng-Yang, Li, Tian-Tian, Lei, Yun-Tao, Gao, Yu-Hao, Li, Qing-Quan, Yue, Chen-Xi, Gao, Yu, Lin, Yi-Yu, Hao, Cui-Yun, Li, Chang-Zhu, Cao, Peng, Zhu, Michael X., Rong, Ming-Qiang, Wang, Wen-Hui, Yu, Ye
Publicado 2023