Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis

por Qiu, Wei, Leibowitz, Brian, Zhang, Lin, Yu, Jian
Publicado 2009

mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death

por Leibowitz, Brian J., Zhao, Guangyi, Xia, Wenxin, Wang, Yuhan, Ruan, Hang, Zhang, Lin, Yu, Jian
Publicado 2023

Interferon b drives intestinal regeneration after radiation

por Leibowitz, Brian J., Zhao, Guangyi, Wei, Liang, Ruan, Hang, Epperly, Michael, Chen, Lujia, Lu, Xinghua, Greenberger, Joel S., Zhang, Lin, Yu, Jian
Publicado 2021

Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer

por Ruan, Hang, Leibowitz, Brian J., Peng, Yingpeng, Shen, Lin, Chen, Lujia, Kuang, Charlie, Schoen, Robert E., Lu, Xinghua, Zhang, Lin, Yu, Jian
Publicado 2022

The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice

por Wei, Liang, Leibowitz, Brian J., Epperly, Michael, Bi, Cheng, Li, Allen, Steinman, Justin, Wipf, Peter, Li, Song, Zhang, Lin, Greenberger, Joel, Yu, Jian
Publicado 2018

γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue

por Orenstein, Alexander, Berlyoung, April S., Rastede, Elizabeth E., Pham, Ha H., Fouquerel, Elise, Murphy, Connor T., Leibowitz, Brian J., Yu, Jian, Srivastava, Tumul, Armitage, Bruce A., Opresko, Patricia L.
Publicado 2017

eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis

por Ruan, Hang, Li, Xiangyun, Xu, Xiang, Leibowitz, Brian J, Tong, Jingshan, Chen, Lujia, Ao, Luoquan, Xing, Wei, Luo, Jianhua, Yu, Yanping, Schoen, Robert E, Sonenberg, Nahum, Lu, Xinghua, Zhang, Lin, Yu, Jian
Publicado 2020

Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation

por Vendetti, Frank P., Leibowitz, Brian J., Barnes, Jennifer, Schamus, Sandy, Kiesel, Brian F., Abberbock, Shira, Conrads, Thomas, Clump, David Andy, Cadogan, Elaine, O’Connor, Mark J., Yu, Jian, Beumer, Jan H., Bakkenist, Christopher J.
Publicado 2017

Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis

por Fletcher, Rochelle, Tong, Jingshan, Risnik, Denise, Leibowitz, Brian, Wang, Yi-Jun, Concha-Benavente, Fernando, DeLiberty, Jonathan M., Stolz, Donna B., Pai, Reet K., Ferris, Robert L., Schoen, Robert E., Yu, Jian, Zhang, Lin
Publicado 2021

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

por Wang, Xinwei, Wei, Liang, Cramer, Julie M., Leibowitz, Brian J., Judge, Colleen, Epperly, Michael, Greenberger, Joel, Wang, Fengchao, Li, Linheng, Stelzner, Matthias G., Dunn, James C. Y., Martin, Martin G., Lagasse, Eric, Zhang, Lin, Yu, Jian
Publicado 2015

Release of Interferon-β (IFN-β) from Probiotic Limosilactobacillus reuteri-IFN-β (LR-IFN-β) Mitigates Gastrointestinal Acute Radiation Syndrome (GI-ARS) following Whole Abdominal I...

por Hamade, Diala F., Epperly, Michael W., Fisher, Renee, Hou, Wen, Shields, Donna, van Pijkeren, Jan-Peter, Mukherjee, Amitava, Yu, Jian, Leibowitz, Brian J., Vlad, Anda M., Coffman, Lan, Wang, Hong, Huq, M. Saiful, Huang, Ziyu, Rogers, Claude J., Greenberger, Joel S.
Publicado 2023

Intestinal Radiation Protection and Mitigation by Second-Generation Probiotic Lactobacillus-reuteri Engineered to Deliver Interleukin-22

por Espinal, Alexis, Epperly, Michael W., Mukherjee, Amitava, Fisher, Renee, Shields, Donna, Wang, Hong, Huq, M. Saiful, Hamade, Diala Fatima, Vlad, Anda M., Coffman, Lan, Buckanovich, Ronald, Yu, Jian, Leibowitz, Brian J., van Pijkeren, Jan-Peter, Patel, Ravi B., Stolz, Donna, Watkins, Simon, Ejaz, Asim, Greenberger, Joel S.
Publicado 2022