The Role of the Immune System in Cutaneous Squamous Cell Carcinoma

por Bottomley, Matthew J., Thomson, Jason, Harwood, Catherine, Leigh, Irene
Publicado 2019

Cutaneous Squamous Cell Carcinoma (SCC) and the DNA Damage Response: pATM Expression Patterns in Pre-Malignant and Malignant Keratinocyte Skin Lesions

por Ismail, Ferina, Ikram, Mohamed, Purdie, Karin, Harwood, Catherine, Leigh, Irene, Storey, Alan
Publicado 2011

Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling

por Bose, Amrita, Teh, Muy-Teck, Hutchison, Iain L., Wan, Hong, Leigh, Irene M., Waseem, Ahmad
Publicado 2012

Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

por Hepburn, Lydia A., McHugh, Angela, Fernandes, Kenneth, Boag, Garry, Proby, Charlotte M., Leigh, Irene M., Saville, Mark K.
Publicado 2018

Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity

por McHugh, Angela, Fernandes, Kenneth, South, Andrew P., Mellerio, Jemima E., Salas-Alanís, Julio C., Proby, Charlotte M., Leigh, Irene M., Saville, Mark K.
Publicado 2018

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mou...

por Kalin, Jay H., Eroglu, Abdulkerim, Liu, Hua, Holtzclaw, W. David, Leigh, Irene, Proby, Charlotte M., Fahey, Jed W., Cole, Philip A., Dinkova-Kostova, Albena T.
Publicado 2019

Binding of Integrin α6β4 to Plectin Prevents Plectin Association with F-Actin but Does Not Interfere with Intermediate Filament Binding

por Geerts, Dirk, Fontao, Lionel, Nievers, Mirjam G., Schaapveld, Roel Q.J., Purkis, Patricia E., Wheeler, Grant N., Lane, E. Birgitte, Leigh, Irene M., Sonnenberg, Arnoud
Publicado 1999

Validation of four cutaneous squamous cell carcinoma staging systems using nationwide data

por Venables, Zoe Claire, Tokez, Selin, Hollestein, Loes M., Mooyaart, Antien L., van den Bos, Renate Ruth, Rous, Brian, Leigh, Irene M., Nijsten, Tamar, Wakkee, Marlies
Publicado 2022

The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma

por McHugh, Angela, Fernandes, Kenneth, Chinner, Nerime, Ibrahim, Adel F.M., Garg, Amit K., Boag, Garry, Hepburn, Lydia A., Proby, Charlotte M., Leigh, Irene M., Saville, Mark K.
Publicado 2020

The Genomic Landscape of Actinic Keratosis

por Thomson, Jason, Bewicke-Copley, Findlay, Anene, Chinedu Anthony, Gulati, Abha, Nagano, Ai, Purdie, Karin, Inman, Gareth J., Proby, Charlotte M., Leigh, Irene M., Harwood, Catherine A., Wang, Jun
Publicado 2021

Genomic analysis of atypical fibroxanthoma

por Lai, Kevin, Harwood, Catherine A., Purdie, Karin J., Proby, Charlotte M., Leigh, Irene M., Ravi, Namita, Mully, Thaddeus W., Brooks, Lionel, Sandoval, Priscilla M., Rosenblum, Michael D., Arron, Sarah T.
Publicado 2017

Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors

por Mannella, Viviana, Boehm, Kira, Celik, Suheyla, Ali, Tasnim, Mirza, Amnah N., El Hasnaouy, Mariam, Kaffa, Andreas, Lyu, Yanshuang, Kafaei Golahmadi, Donya, Leigh, Irene M., Bergamaschi, Daniele, Harwood, Catherine A., Maffucci, Tania
Publicado 2021

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

por Maruthappu, Thiviyani, Chikh, Anissa, Fell, Benjamin, Delaney, Paul J., Brooke, Matthew A., Levet, Clemence, Moncada-Pazos, Angela, Ishida-Yamamoto, Akemi, Blaydon, Diana, Waseem, Ahmad, Leigh, Irene M., Freeman, Matthew, Kelsell, David P.
Publicado 2017

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

por Purdie, Karin J., Proby, Charlotte M., Rizvi, Hasan, Griffin, Heather, Doorbar, John, Sommerlad, Mary, Feltkamp, Mariet C., der Meijden, Els Van, Inman, Gareth J., South, Andrew P., Leigh, Irene M., Harwood, Catherine A.
Publicado 2018

Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength

por Huen, Arthur C., Park, Jung K., Godsel, Lisa M., Chen, Xuejun, Bannon, Leslie J., Amargo, Evangeline V., Hudson, Tracie Y., Mongiu, Anne K., Leigh, Irene M., Kelsell, David P., Gumbiner, Barry M., Green, Kathleen J.
Publicado 2002

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

por Hassan, Sakinah, Purdie, Karin J., Wang, Jun, Harwood, Catherine A., Proby, Charlotte M., Pourreyron, Celine, Mladkova, Nikol, Nagano, Ai, Dhayade, Sandeep, Athineos, Dimitris, Caley, Matthew, Mannella, Viviana, Blyth, Karen, Inman, Gareth J., Leigh, Irene M.
Publicado 2019

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

por Rose, Aidan M., Spender, Lindsay C., Stephen, Christopher, Mitchell, Alastair, Rickaby, William, Bray, Susan, Evans, Alan T., Dayal, Jasbani, Purdie, Karin J., Harwood, Catherine A., Proby, Charlotte M., Leigh, Irene M., Coates, Philip J., Inman, Gareth J.
Publicado 2018

p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis

por Matin, Rubeta N., Chikh, Anissa, Law Pak Chong, Stephanie, Mesher, David, Graf, Manuela, Sanza’, Paolo, Senatore, Valentina, Scatolini, Maria, Moretti, Francesca, Leigh, Irene M., Proby, Charlotte M., Costanzo, Antonio, Chiorino, Giovanna, Cerio, Rino, Harwood, Catherine A., Bergamaschi, Daniele
Publicado 2013

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

por Inman, Gareth J., Wang, Jun, Nagano, Ai, Alexandrov, Ludmil B., Purdie, Karin J., Taylor, Richard G., Sherwood, Victoria, Thomson, Jason, Hogan, Sarah, Spender, Lindsay C., South, Andrew P., Stratton, Michael, Chelala, Claude, Harwood, Catherine A., Proby, Charlotte M., Leigh, Irene M.
Publicado 2018

Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa

por Watt, Stephen A., Dayal, Jasbani H. S., Wright, Sheila, Riddle, Megan, Pourreyron, Celine, McMillan, James R., Kimble, Roy M., Prisco, Marco, Gartner, Ulrike, Warbrick, Emma, McLean, W. H. Irwin, Leigh, Irene M., McGrath, John A., Salas-Alanis, Julio C., Tolar, Jakub, South, Andrew P.
Publicado 2015