A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation

por Leighton, Philip A., Schusser, Benjamin, Yi, Henry, Glanville, Jacob, Harriman, William
Publicado 2015

V(D)J Rearrangement Is Dispensable for Producing CDR-H3 Sequence Diversity in a Gene Converting Species

por Leighton, Philip A., Morales, Jacqueline, Harriman, William D., Ching, Kathryn H.
Publicado 2018

Expression of human lambda expands the repertoire of OmniChickens

por Ching, Kathryn H., Berg, Kimberley, Morales, Jacqueline, Pedersen, Darlene, Harriman, William D., Abdiche, Yasmina N., Leighton, Philip A.
Publicado 2020

Harnessing Gene Conversion in Chicken B Cells to Create a Human Antibody Sequence Repertoire

por Schusser, Benjamin, Yi, Henry, Collarini, Ellen J., Izquierdo, Shelley Mettler, Harriman, William D., Etches, Robert J., Leighton, Philip A.
Publicado 2013

Generation of chickens expressing Cre recombinase

por Leighton, Philip A., Pedersen, Darlene, Ching, Kathryn, Collarini, Ellen J., Izquierdo, Shelley, Jacob, Roy, van de Lavoir, Marie-Cecile
Publicado 2016

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

por Ching, Kathryn H., Berg, Kimberley, Reynolds, Kevin, Pedersen, Darlene, Macias, Alba, Abdiche, Yasmina N., Harriman, William D., Leighton, Philip A.
Publicado 2021

Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ Cells

por Dimitrov, Lazar, Pedersen, Darlene, Ching, Kathryn H., Yi, Henry, Collarini, Ellen J., Izquierdo, Shelley, van de Lavoir, Marie-Cecile, Leighton, Philip A.
Publicado 2016

Interspecific Germline Transmission of Cultured Primordial Germ Cells

por van de Lavoir, Marie-Cecile, Collarini, Ellen J., Leighton, Philip A., Fesler, Jeffrey, Lu, Daniel R., Harriman, William D., Thiyagasundaram, T. S., Etches, Robert J.
Publicado 2012

Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

por Cameron, Beatrice, Dabdoubi, Tarik, Berthou-Soulié, Laurence, Gagnaire, Marie, Arnould, Isabelle, Severac, Anne, Soubrier, Fabienne, Morales, Jacqueline, Leighton, Philip A., Harriman, William, Ching, Kathryn, Abdiche, Yasmina, Radošević, Katarina, Bouquin, Thomas
Publicado 2020

Expression of heavy chain‐only antibodies can support B‐cell development in light chain knockout chickens

por Schusser, Benjamin, Collarini, Ellen J., Pedersen, Darlene, Yi, Henry, Ching, Kathryn, Izquierdo, Shelley, Thoma, Theresa, Lettmann, Sarah, Kaspers, Bernd, Etches, Robert J., van de Lavoir, Marie‐Cecile, Harriman, William, Leighton, Philip A.
Publicado 2016

Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets

por Ching, Kathryn H., Collarini, Ellen J., Abdiche, Yasmina N., Bedinger, Daniel, Pedersen, Darlene, Izquierdo, Shelley, Harriman, Rian, Zhu, Lei, Etches, Robert J., van de Lavoir, Marie-Cecile, Harriman, William D., Leighton, Philip A.
Publicado 2017