Quantitative Systems Pharmacology can reduce attrition and improve productivity in pharmaceutical research and development

por Leil, Tarek A., Bertz, Richard
Publicado 2014

Editorial: The emerging discipline of quantitative systems pharmacology

por Leil, Tarek A., Ermakov, Sergey
Publicado 2015

Use of systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans

por Lu, Yasong, Griffen, Steven C., Boulton, David W., Leil, Tarek A.
Publicado 2014

Model‐Based Meta‐Analysis Compares DAS28 Rheumatoid Arthritis Treatment Effects and Suggests an Expedited Trial Design for Early Clinical Development

por Leil, Tarek A., Lu, Yasong, Bouillon‐Pichault, Marion, Wong, Robert, Nowak, Miroslawa
Publicado 2020

Antibodies to Modulate Surface Receptor Systems Are Often Bivalent and Must Compete in a Two‐Dimensional Cell Contact Region

por Schmidt, Brian J., Bee, Christine, Han, Minhua, Jing, Yawu, Cheng, Yougan, Tenney, Daniel J., Leil, Tarek A.
Publicado 2019

Virtual Systems Pharmacology (ViSP) software for simulation from mechanistic systems-level models

por Ermakov, Sergey, Forster, Peter, Pagidala, Jyotsna, Miladinov, Marko, Wang, Albert, Baillie, Rebecca, Bartlett, Derek, Reed, Mike, Leil, Tarek A.
Publicado 2014

Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon‐γ–Induced Protein 10, BMS‐986184, in Healthy Participants t...

por Cai, Weiguo, Leil, Tarek A., Gibiansky, Leonid, Krishna, Murli, Zhang, Hongwei, Gu, Huidong, Sun, Huadong, Throup, John, Banerjee, Subhashis, Girgis, Ihab
Publicado 2020

A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

por Kierzek, Andrzej M., Hickling, Timothy P., Figueroa, Isabel, Kalvass, J. Cory, Nijsen, Marjoleen, Mohan, Krithika, Veldman, Geertruida M., Yamada, Akihiro, Sayama, Hiroyuki, Yokoo, Sachiko, Gulati, Abhishek, Dhanikula, Renu S., Gokemeijer, Jochem, Leil, Tarek A., Thalhauser, Craig J., Giorgi, Mario, Swat, Maciej J., Chelliah, Vijayalakshmi, Small, Ben G., Benson, Neil, Walker, Michael, Gadkar, Kapil, Quarmby, Valerie, Deng, Rong, Ferrante, Andrea, Dickinson, Gemma L., Van Der Walt, Jan‐Stefan, Zhou, Lian, Chen, Xiaoying, Jones, Hannah M., Narula, Jatin, Tourdot, Sophie, Lavé, Thierry, Ribba, Benjamin, van der Graaf, Piet H.
Publicado 2019