3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

por Pustenko, Aleksandrs, Stepanovs, Dmitrijs, Žalubovskis, Raivis, Vullo, Daniela, Kazaks, Andris, Leitans, Janis, Tars, Kaspars, Supuran, Claudiu T.
Publicado 2017

Aryl-4,5-dihydro-1H-pyrazole-1-carboxamide Derivatives Bearing a Sulfonamide Moiety Show Single-digit Nanomolar-to-Subnanomolar Inhibition Constants against the Tumor-associated Hu...

por Hargunani, Priya, Tadge, Nikhil, Ceruso, Mariangela, Leitans, Janis, Kazaks, Andris, Tars, Kaspars, Gratteri, Paola, Supuran, Claudiu T., Nocentini, Alessio, Toraskar, Mrunmayee P.
Publicado 2020

Extending the Inhibition Profiles of Coumarin-Based Compounds Against Human Carbonic Anhydrases: Synthesis, Biological, and In Silico Evaluation

por Kartsev, Victor, Geronikaki, Athina, Bua, Silvia, Nocentini, Alessio, Petrou, Anthi, Lichitsky, Boris, Frasinyuk, Mykhaylo, Leitans, Janis, Kazaks, Andris, Tars, Kaspars, Supuran, Claudiu T.
Publicado 2019

N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms

por Bianco, Giulia, Meleddu, Rita, Distinto, Simona, Cottiglia, Filippo, Gaspari, Marco, Melis, Claudia, Corona, Angela, Angius, Rossella, Angeli, Andrea, Taverna, Domenico, Alcaro, Stefano, Leitans, Janis, Kazaks, Andris, Tars, Kaspars, Supuran, Claudiu T., Maccioni, Elias
Publicado 2017

Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells

por Kazokaitė, Justina, Niemans, Raymon, Dudutienė, Virginija, Becker, Holger M., Leitāns, Jānis, Zubrienė, Asta, Baranauskienė, Lina, Gondi, Gabor, Zeidler, Reinhard, Matulienė, Jurgita, Tārs, Kaspars, Yaromina, Ala, Lambin, Philippe, Dubois, Ludwig J., Matulis, Daumantas
Publicado 2018

Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX

por Zakšauskas, Audrius, Čapkauskaitė, Edita, Paketurytė-Latvė, Vaida, Smirnov, Alexey, Leitans, Janis, Kazaks, Andris, Dvinskis, Elviss, Stančaitis, Laimonas, Mickevičiūtė, Aurelija, Jachno, Jelena, Jezepčikas, Linas, Linkuvienė, Vaida, Sakalauskas, Andrius, Manakova, Elena, Gražulis, Saulius, Matulienė, Jurgita, Tars, Kaspars, Matulis, Daumantas
Publicado 2021